A5048207137- T-cell and Retrovirus Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Bone Tumor Diagnosis and Treatments
- Autophagy in Disease and Therapy
- Neuropeptides and Animal Physiology
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Extracellular vesicles in disease
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Hedgehog Signaling Pathway Studies
Army Medical University
2016-2025
Xinqiao Hospital
2016-2025
Guangdong Medical College
2025
Dongguan People’s Hospital
2025
Second Affiliated Hospital of Fujian Medical University
2020-2024
Fujian Medical University
2020-2024
Deyang Stomatological Hospital
2023
Weatherford College
2023
Southwest Hospital
2005-2014
First Affiliated Hospital of Chinese PLA General Hospital
2013
Microenvironmental regulation of cancer stem cells (CSCs) strongly influences the onset and spread cancer. The way in which glioma interact with their microenvironment acquire phenotypes CSCs remains elusive. We investigated how communication between vascular endothelial promoted properties (GSCs). observed that CD133(+) GSCs were located closely to Shh(+) specimens human glioblastoma multiforme (GBM). In both vitro vivo studies, we found appearance CSC-like cells, as demonstrated by...
Over the last two or three decades, pace of development treatments for osteosarcoma tends has been slow. Novel effective therapies are still lacking. Previously, we reported that tumor-suppressing STF cDNA 3 (TSSC3) functions as an imprinted tumor suppressor gene in osteosarcoma; however, underlying mechanism by which TSSC3 suppresses tumorigenesis and metastasis remain unclear. We investigated dynamic expression patterns autophagy-related proteins (autophagy related 5 (ATG5) P62) 33 human...
Abstract Background Tandem C2 domains, nuclear (TC2N) is a domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem family, and acts as an oncogenic driver in several cancers. Previously, we preliminarily reported TC2N mediates PI3K-Akt signaling pathway inhibit tumor growth of breast cancer (BC) cells. Beyond that, its precise biological functions detailed molecular mechanisms BC development progression are not fully understood. Methods Tumor tissues 212 patients...
This study aimed to determine whether formyl peptide receptors (FPRs) regulated the differentiation of neural stem cells (NSCs). FPRs promote migration NSCs both in vitro and vivo. However, role during is unknown. Analysis by Western blot showed significantly increased expression FPR1 FPR2 NSCs. The activation promotes differentiate into neurons with more primary neurites branch points longer per cell. Meanwhile, this also inhibits NSC astrocytes. bidirectional effect can be inhibited...
Abstract The enhancer of zeste homolog 2 ( EZH2 ) methyltransferase is the catalytic subunit polycomb repressive complex (PRC2), which acts as a transcription repressor via trimethylation lysine 27 histone 3 (H3K27me3). has been recognised an oncogene in several types tumors; however, its role osteosarcoma not fully elucidated. Herein, we show that silencing inhibits tumor growth and lung metastasis by facilitating re-expression imprinting gene tumor-suppressing STF cDNA TSSC3 ). Our...
Background As a kind of small membrane vesicles, exosomes are secreted by most cell types from multivesicular endosomes, including tumor cells. The relationship between and immune response plays vital role in the occurrence development tumors. Nevertheless, interaction microenvironment tumors remains unclear. Therefore, we set out to study influence on triple-negative breast cancer (TNBC) microenvironment. Method One hundred twenty-one exosome-related genes were downloaded ExoBCD database,...
Abstract Background Tandem C2 domains, nuclear (TC2N) is a protein that has been characterized to contain C2A domain, C2B and short C-terminus with WHXL motif. In previous studies, we have uncovered the oncogenic role mechanisms of TC2N in lung cancer: achieves this by inhibiting p53 signaling pathway activating NF-kappaB pathway. Beyond that, its precise function tumorigenesis not fully understood. Methods TC2N-engineered mice model was used assess effect knockout on normal urethane-induced...
Abstract Breast cancer (BC) is a leading cause of mortality among women globally. Emerging evidence suggests that the immune system involved in BC pathogenesis, with distinct subtypes showing unique responses. Inflammation correlates closely these However, causal role cell characteristics across and mediating influence inflammatory proteins remains unclear. We used bi-directional two-sample Mendelian Randomization (MR) to evaluate relationships between 731 traits risk, including its...
<title>Abstract</title> <bold>Background</bold>: Growing evidence indicates that the imbalances in gut microbiota influence brain structural connectivity, a key component of microbiota-gut-brain axis. However, deeper understanding this complex bidirectional relationship remains elusive. This study aims to deepen our by examining underlying causal and mediating role inflammatory cytokines. <bold>Methods</bold>: analyzed GWAS data from 18,340 participants for composition MRI 82,382...
Abstract Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected on neurons in central nervous system (CNS). Here, we report that Fpr1 Fpr2 are expressed NSCs as with immunohistochemistry, RT-PCR WB assays. In addition, promoted NSC through F-actin...
Abstract Objective To explore the role of ADMA in gastric cancer. Methods The specimens 115 cancer patients were analyzed by ELISA and survival analysis. Functional assays used to assess effects on cells. Experiments conducted detect signaling pathway induced GC. Results Gastric with high levels had poor prognosis low rate. Furthermore, level did not affect proliferation while promoted migration invasion cell. Moreover, enhanced epithelial–mesenchymal transition (EMT). Importantly,...
Natural killer (NK) cells are crucial to the emergence, identification, and prognosis of cancers. The roles NK cell-related genes in tumor immune microenvironment (TIME) immunotherapy treatment unclear. Triple-negative breast cancer (TNBC) is a highly aggressive malignant tumor. Hence, this study was conducted develop reliable risk model related provide novel system for predicting TNBC.NK were collected from previous studies. Based on TCGA GEO database, univariate LASSO cox regression...
Loss of expression TSSC3 , an apoptosis-related imprinted gene, has been reported in several cases malignant tumors. However, the roles and mechanisms human osteosarcoma remain to be defined. In this study, we found downregulated during transformation progression cell lines tissues. The SaOS2 line was used further evaluate precise role development. Overexpression markedly reduced vitality growth, colony formation, Ki67 as well cycle arrest G 0 /G 1 phase. Consistently, overexpression...
Abstract Suppression of anoikis is a prerequisite for tumor cell metastasis, which correlated with chemoresistance and poor prognosis. We characterized novel interaction between RanBP9 SPRY domain TSSC3 PH by RanBP9/TSSC3 complex exerts transcription post-translation regulation in osteosarcoma. was inversely highly anoikis-resistant phenotype osteosarcoma cells metastasis human cooperated to inhibit anchorage-independent growth promote vitro suppress lung vivo . Moreover, required...
Abstract The aim of this study was to investigate the mechanism by which growth arrest‐specific transcript 5 (GAS5) regulates bladder cancer cells. Bladder samples were collected and tested for experiment. Dual‐luciferase reporter assay used verify downstream target genes GAS5 miR‐21. expression level decreased that miR‐21 increased, indicating a negative correlation between two. Patients with high low had relatively longer survival rates. inhibited cells proliferation promoted apoptosis,...
Background: Notch signaling abnormalities are associated with the development of various tumors, including hematopoietic and epithelium-derived tumors. However, role in tumors originating from mesenchymal cells is unclear. The effect Notch3 expression on prognosis osteosarcoma its mechanism have never been reported. Materials methods: In this study, we performed a clinicopathological analysis 70 cases osteosarcoma, primary focus survival. Osteosarcoma cell lines MTH U2OS were used. After...
Tumor cells must resist anoikis to metastasize. There is a key role of angiogenesis in the growth and metastasis tumors. However, relationship between resistance has not been well explored human osteosarcoma. In present study, we reported higher expression vascular endothelial factor‑A (VEGF‑A) osteosarcoma that were resistant than parental cells, promoting proliferation, tube formation, migration umbilical vein (HUVECs). Src, JNK (Jun amino‑terminal kinase) ERK (extracellular...
Abstract Metabolic reprogramming has become a hot topic recently in the regulation of tumour biology. Although hundreds altered metabolic genes have been reported to be associated with development and progression, important prognostic role these remains unknown. We downloaded messenger RNA expression profiles clinicopathological data from The Cancer Genome Atlas Gene Expression Omnibus database uncover genes. Univariate Cox regression analysis lasso model were utilized this study screen...