A5100638552- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Atmospheric Ozone and Climate
- Isotope Analysis in Ecology
- Air Quality Monitoring and Forecasting
- Atmospheric and Environmental Gas Dynamics
- Geological and Geochemical Analysis
- Hydrocarbon exploration and reservoir analysis
- Traditional Chinese Medicine Studies
- Geology and Paleoclimatology Research
- Vitamin D Research Studies
- Hormonal Regulation and Hypertension
- Groundwater and Isotope Geochemistry
- Phytochemistry and Biological Activities
- Soil Carbon and Nitrogen Dynamics
- Atmospheric aerosols and clouds
- Marine and coastal ecosystems
- Renin-Angiotensin System Studies
- Geochemistry and Elemental Analysis
- Geochemistry and Geologic Mapping
- Chinese history and philosophy
- Botulinum Toxin and Related Neurological Disorders
- Methane Hydrates and Related Phenomena
- China's Ethnic Minorities and Relations
- Medicinal Plants and Bioactive Compounds
University of Science and Technology of China
2021-2025
Chongqing University
2024
Hangzhou Normal University
2023
Research Institute of Petroleum Exploration and Development
2022-2023
East China University of Technology
2018-2022
Shandong University of Finance and Economics
2022
China National Petroleum Corporation (China)
2022
East China Normal University
2022
Beijing Forestry University
2022
Nanjing Polytechnic Institute
2021
The renin-angiotensin system (RAS) plays a critical role in the development of diabetic nephropathy, and blockade RAS is currently used for treatment nephropathy. One major problem current inhibitors compensatory renin increase, which reduces efficacy inhibition. We have shown that vitamin D exerts renoprotective actions by transcriptionally suppressing renin. Here we demonstrated combination therapy with an AT1 receptor blocker analog markedly ameliorated renal injury streptozotocin...
Vitamin D and its analogs have antiproteinuric activity podocytes express the vitamin receptor, but whether signaling in accounts for this renoprotection is unknown. To investigate question, we used 2.5 kb podocin promoter to target Flag-tagged human receptor (hVDR) DBA/2J mice. After induction of diabetes with streptozotocin, transgenic mice had less albuminuria than wild-type controls. In mice, a low dose analog doxercalciferol prevented albuminuria, markedly attenuated podocyte loss...
The renin-angiotensin system (RAS) is a major mediator of renal injury in diabetic nephropathy. Our previous studies demonstrated that 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] plays renoprotective role by suppressing the RAS, with renin and angiotensinogen (AGT) as main targets. mechanism whereby 1,25(OH)(2)D(3) transcriptionally suppresses gene expression has been elucidated; however, how vitamin D regulates AGT remains unknown. Exposure mesangial cells or podocytes to high glucose (HG;...
BackgroundWe recently reported that the gut epithelial vitamin D receptor (VDR) signaling inhibits colitis through inhibition of intestinal cell apoptosis, and level colonic VDR is markedly reduced in patients with inflammatory bowel diseases (IBD). downregulation promotes colitis, but mechanism underlying IBD unknown.
The intrarenal renin-angiotensin system (RAS) plays a key role in the development of diabetic nephropathy. Recently, we showed that combination therapy with an AT(1) receptor blocker (ARB) and activated vitamin D analog produced excellent synergistic effects against nephropathy, as result blockade ARB-induced compensatory renin increase. Given diversity analogs, here used pro-drug analog, doxercalciferol (1alpha-hydroxyvitamin D(2)), to further test efficacy strategy long-term treatment....
Liver resection is the first-line treatment for patients with resectable colorectal liver metastasis (CRLM), while radiofrequency ablation (RFA) can be used small unresectable CRLM because of disease extent, poor anatomical location, or comorbidities. However, long-term outcomes are unclear RFA in CRLM. This study aimed to compare recurrence rates and prognosis between receiving either RFA. Consecutive who underwent hepatic from November 2010 December 2015 were assigned this retrospective...
Abstract Nitrate (NO 3 − ), one of the most important inorganic aerosols in atmosphere, is mainly formed by oxidation NO x hydroxyl radical (OH) and ozone (O ) urban atmospheres. However, fractional contributions its various pathways remain unclear. Here, we collected particulate matter with aerodynamic diameter less than 2.5 μm (PM samples a second‐tier city southeast China from 1 September to 31 December 2017 measured nitrate isotopic compositions (δ 15 N δ 18 O). The average concentration...
Chlorine is an important atmospheric photochemical oxidant, but few studies have focused on chlorine. In this study, PM2.5 samples were collected from urban and rural sites across China in January 2018, concentrations of Cl− other water-soluble ions analyzed. The size-segregated aerosol data measured Chinese cities by compiled for comparison. observed demonstrated that the northern (5.0 ± 3.7 µg/m3) higher than those central (1.9 1.2 southern (0.84 0.54 µg/m3), suggesting substantial...
Vortex lines, known as topological defects, are cable of trapping Majorana modes in superconducting materials. Previous studies have primarily focused on bands with conventional s-wave pairing. However, Dirac semimetals exhibiting a unique orbital texture can favor unconventional pairing when electronic correlations significant. The topology vortices these systems has yet to be explored. In this work, we investigate the vortex bound states semimetals, particular focus orbital-singlet...