A5101418432- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Asthma and respiratory diseases
- interferon and immune responses
- Mechanisms of cancer metastasis
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Iron Metabolism and Disorders
- Biomarkers in Disease Mechanisms
- Endometriosis Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Retinal Imaging and Analysis
- Bladder and Urothelial Cancer Treatments
- IL-33, ST2, and ILC Pathways
- Intraperitoneal and Appendiceal Malignancies
- Fungal Biology and Applications
- Nigella sativa pharmacological applications
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Apelin-related biomedical research
- Cancer, Lipids, and Metabolism
- Chronic Kidney Disease and Diabetes
Zunyi Medical University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Huazhong University of Science and Technology
2020-2024
Tongji Hospital
2020-2024
Yunnan University of Traditional Chinese Medicine
2023-2024
Southern Medical University
2014-2024
Yunnan University
2024
The First People's Hospital of Zhaoqing
2022
Abstract The exosomes are involved in intercellular communication via RNA trafficking human diseases. Hsa_circ_0009910 (circ_0009910) is a novel leukemia‐related circular RNA. However, the mechanism of circ_0009910 acute myeloid leukemia (AML) cell‐to‐cell remained obscure. Expression circ_0009910, miRNA (miR)‐5195‐3p and growth factor receptor‐bound protein 10 (GRB10) was detected by quantitative real‐time polymerase chain reaction Western blotting. A stable cell coculture model established...
Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy. Circular RNAs (circRNAs) play crucial roles in AML progression. This study aimed to explore the function and potential mechanism of circRNA Scm like with four mbt domains 2 (circ-SFMBT2; hsa_circ_0017639) AML.The levels circ-SFMBT2, microRNA-582-3p (miR-582-3p) zinc finger BTB domain containing 20 (ZBTB20) were measured by quantitative real-time PCR Western blot. Cell Counting Kit-8 (CCK-8), colony formation,...
<title>Abstract</title> Background Peritoneal metastases (PM) after radical surgery is an important reason for the treatment failure in colorectal cancer (CRC). The intraoperatively intraperitoneal perfusion chemotherapy may be effective method to prevent postoperative PM of CRC. We aimed explore safety and feasibility preventive with lobaplatin Methods Between December 12, 2017 October 17, 2019, 720 eligible CRC patients which clinical TNM stage was T4 or N + were recruited from 25...
Cold atmospheric plasma (CAP) has been proposed as an emerging onco-therapeutics that can specifically kill cancer cells without harming healthy cells.Here we explore its potency in triggering ferroptosis transformed using triple negative breast the disease model.Through whole transcriptome sequencing, mass spectrometry analysis, point mutation, and a series of vitro vivo molecular assays, identified two signaling axes centered at EGFR(Y1068), i.e., EGFR-TRIM25-KEAP1/SIAH2-NRF2...
Introduction The human gamma-glutamyltransferase (GGT) is a membrane-bound extracellular glycoprotein with an enzymatic activity that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides transfers the moiety to acceptors. It has been shown aberrant expression of GGT proteins cancers while their profiles prostate are not reported. Methods In this study, we analyzed all protein-coding genes using TCGA-PRAD RNA-seq dataset derived from primary cancers. family gene were also...
Centromere protein F (CENPF) is a associated with the centromere-kinetochore complex and chromosomal segregation during mitosis. Previous studies have demonstrated that upregulation of CENPF may be used as proliferation marker malignant cell growth in tumors. The overexpression has also been reported to poor prognosis human cancers. However, clinical significance prostate cancer (PCa) not yet fully elucidated. Thus, aim present study was determine association tumor progression patients PCa....
Abstract The aim of this study was to investigate the mechanism by which growth arrest‐specific transcript 5 (GAS5) regulates bladder cancer cells. Bladder samples were collected and tested for experiment. Dual‐luciferase reporter assay used verify downstream target genes GAS5 miR‐21. expression level decreased that miR‐21 increased, indicating a negative correlation between two. Patients with high low had relatively longer survival rates. inhibited cells proliferation promoted apoptosis,...
Abstract Acute myeloid leukemia (AML) is a highly heterogeneous disease featured by clonal proliferation derived from primitive hematopoietic stem/progenitor cells. Circular RNAs (circRNAs) have been identified as crucial regulators in the progression of various cancers, including AML. However, molecular mechanism AML still not definite. This study aimed to explore influences circ_0012152 on cell development cells and underlying regulatory mechanism. The expression circ_0012152,...
Abstract Circular RNAs are relevant to progression of acute myeloid leukemia (AML). Nevertheless, how and whether hsa_circ_0002483 (circ_0002483) participates in AML largely uncertain. The bone marrow samples were harvested from 31 patients or normal subjects. Circ_0002483, microRNA (miR)‐758‐3p myelocytomatosis oncogene (MYC) abundances examined via quantitative reverse transcription polymerase chain reaction Western blot. Cell proliferation, cycle process apoptosis analyzed Counting Kit‐8,...
Novel molecular markers are important diagnostic tools for the assessment of cancer progression and evaluation effectiveness treatment. SOX9, a key regulator developmental processes, is overexpressed in various neoplasms, such as prostate, breast, colorectal cancers. However, utilization SOX9 biomarker other urological cancers has not yet been investigated.In present study, paired patient tissue microarrays were analyzed by immunohistochemistry, protein expression was quantitated...
Background Acute myeloid leukemia (AML) is one of the most common malignant diseases in adults with a dismal prognosis. We aimed to explore effects circNFIX on proliferation and apoptosis AML cells.Methods The expressions circNFIX, miR-876-3p tripartite motif (TRIM) 31 bone marrow specimens patients cell lines were detected by qRT-PCR or western blot. Cell was evaluated 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) 5-ethynyl-29-deoxyuridine (EdU) assays. cycle analyzed...
Abstract Tripartite motif (TRIM) 31 is a member of TRIM family and exerts oncogenic role in the progression drug resistance several cancers. However, little known about relevance TRIM31 acute myeloid leukemia (AML). Herein, we investigated AML. We examined expression levels blood samples from 34 patients with AML healthy volunteers using qRT-PCR. The mRNA human bone marrow stromal cells (HS-5) five cell lines were also detected. Loss/gain-of-function assays performed to assess proliferation,...
Abstract Background Solute Carrier Family 6 Member 1 (SLC6A1) has been identified as a cancer-promoting gene in various human cancers, such clear cell renal carcinoma and ovarian cancer. However, its roles prostate cancer (PCa) not fully elucidated. The aim of this study was to investigate the expression clinical significance SLC6A1 PCa tissues effect on drug resistance docetaxel PCa. Methods Expression patterns protein were examined by immunohistochemistry based Tissue microarray....
Circular RNA (circRNA) regulates the pathogenesis of acute myeloid leukemia (AML). However, mechanism circRNA protein tyrosine kinase 2 (circPTK2) in AML remains unclear.Quantitative real-time polymerase chain reaction (qRT-PCR) assay was adopted for circPTK2, miR-582-3p and alpha-1,3-mannosyltransferase (ALG3) mRNA levels. 3-(4, 5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay, 5'-ethynyl-2'-deoxyuridine (EdU) were conducted cell proliferation. Flow cytometry...
Correlation of sex determining region Y‑box (SOX)9 and NM23 genes with the incidence prognosis prostate cancer (PC) was investigated. SOX9‑small interfering ribonucleic acid (siRNA) NM23‑siRNA were constructed transfected into PC‑3 cells. The expression levels SOX9 messenger RNAs (mRNAs) proteins in cells detected via reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) western blotting. MTT assay adopted to examine proliferation ability cells, Transwell applied detect...
INTRODUCTIONHereditary thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive inherited disease involving the ADMATS13 gene. Common causes of TTP include infection, inflammation or pregnancy. However, hereditary occurs mostly in children and pregnant women, accounting for only 5% all total cases TTP.1Homozygous double heterozygous mutations theADAMTS13 gene, result plasma ADAMTS13 activity absence severe deficiency. located on chromatin 9q34, contains 29 exons, encodes 1427...
Children are highly susceptible to influenza and at high risk for severe cases. Chinese patent medicine (CPM) offers advantages in treating pediatric influenza, but the issue of its improper use is increasingly prevalent clinical practice. To address this, we adopted a dual leadership approach involving methodological experts, guided by evidence-based practice principles. We referred existing guidelines, consensus statements, treatment protocols, designed relevant questions based on “3...