A5089800624- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Drug Transport and Resistance Mechanisms
- Asthma and respiratory diseases
- Autophagy in Disease and Therapy
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Carbon and Quantum Dots Applications
- Autoimmune and Inflammatory Disorders Research
- Toxin Mechanisms and Immunotoxins
- Rheumatoid Arthritis Research and Therapies
- Exercise and Physiological Responses
- Ferroptosis and cancer prognosis
- NF-κB Signaling Pathways
- Pharmacogenetics and Drug Metabolism
- Epigenetics and DNA Methylation
- Dendrimers and Hyperbranched Polymers
- Traditional Chinese Medicine Studies
- Graphene and Nanomaterials Applications
- Allergic Rhinitis and Sensitization
- Quinazolinone synthesis and applications
- Natural Compounds in Disease Treatment
- Intramuscular injections and effects
- Blood groups and transfusion
- Advanced Nanomaterials in Catalysis
Anhui Medical University
2022-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2013-2025
Shanghai Ocean University
2023-2025
Jiangsu Food and Pharmaceutical Science College
2024
Henan University
2022-2023
Hefei University of Technology
2022
Zhejiang University
2020
Hunan University of Traditional Chinese Medicine
2003-2019
CM Hospital
2003
In this work, we reported a strategy to synthesize well-defined bottlebrush polymers. Diazoacetate macromonomers of polystyrene (1-PSn) with controlled molecular weights were prepared via reversible addition–fragmentation chain transfer (RAFT) polymerization. The diazo can tolerate the RAFT polymerization conditions and remained on end yielded PS macromonomer. terminal groups macromonomer polymerized by allyl PdCl/L catalyst afford polymers ((1-PSn)ms) carrying side each backbone atom....
Ulcerative colitis (UC) is a chronic, non-specific inflammatory disease affecting the colon and rectum, classified as type of bowel (IBD). This study aimed to evaluate therapeutic effects Haematococcus carbon dots (HP-CDs) on dextran sulfate sodium (DSS)-induced ulcerative in mice. HP-CDs were synthesized from pluvialis (HP) using hydrothermal method involving Rhodococcus amphitrite. The DSS-induced mice evaluated through histological pathological analyses. Results demonstrated that...
The role of Bone marrow mesenchymal stem cells (BMSCs) and their exosomes in regulating the host response to viral infections has garnered significant attention, yet research on specific mechanisms respiratory syncytial virus (RSV) infection remains limited. This study analyzes changes cytokine levels exosomal miRNA expression profiles BMSCs supernatants following RSV infection. findings reveal that leads a decrease IL-4 supernatants, alongside notable increases IL-6, IL-12, IFN-γ levels....
Umbelliferone (UMB), a natural coumarin compound, has been reported to possess anti-rheumatic effects on rheumatoid arthritis (RA) experimental models, but its potential role of UMB in regulating migration, invasion and inflammation RA fibroblast-like synoviocytes (FLS) remain unclear. Herein, MTT assay was performed confirm the non-cytotoxic concentrations (10, 20, 40[Formula: see text][Formula: text]M) treatment time (24[Formula: text]h) TNF-[Formula: text]-stimulated FLS (MH7A cells)...
BACKGROUND:Dendritic cell autophagy plays a pivotal role in asthma. Wuhu decoction can significantly improve respiratory syncytial virus (RSV) bronchiolitis and delay its development into The aim of the present study was to explore therapeutic effect mechanism on RSV -induced asthma mice. MATERIAL AND METHODS:Establishment asthmatic mice model induced by RSV. Hematoxylin-eosin staining, periodic acid-Schiff (PAS) Masson trichrome staining were performed observe pathological changes lungs....
WuHuTang (WHT) is a traditional Chinese medicine compound for treating asthma, and the evidence supports that it has good effect on acute asthma attacks in children adults. Respiratory syncytial virus (RSV) an important factor pathogenesis of attacks, dendritic cells key to its pathogenesis. Previous studies have confirmed viruses related exosomes. However, there are few exosomes induced by RSV. Whether WHT can improve changes caused RSV-induced or not worthy further exploration.
This work was undertaken to observe therapeutic effect of Xiebai and Zengye (XBZY) decoction on post-infectious cough (PIC) in rats, as well its gut microbiota the exploration intestinal microecological mechanisms XBZY treatment PIC. Using a random number table, rats that were successfully modelled assigned PIC, group (14.8 g/kg/d), montelukast sodium (MAS) (1 mg/kg/d). The sensitivity changes fecal water content assessed, serum interleukin-8 (IL-8) tumor necrosis factor-alpha (TNF-α) levels...
Histone lysine N‑methyltransferase 2C (KMT2C) is involved in transcriptional regulation and DNA damage repair. Mutations KMT2C have been implicated the progression, metastasis, drug resistance of multiple cancer types. However, roles tumor prognosis, immune cell infiltration microenvironment these types remain unclear. Therefore, present study, data from The Cancer Genome Atlas Genotype‑Tissue Expression databases were used for expression analyses. Kaplan‑Meier univariate Cox regression...
This study utilized a prospective, large-sample, multi-center, and registered key specialty approach of hospitals to monitor the application Reduning Injection. A total 100 249 adolescent patients aged 14 years below who received Injection were monitored, resulting in 83 cases adverse events, with 76 them being classified as drug reaction(ADR). The calculated incidence rate ADR for was 0.076%, indicating very rare ADR. main symptoms pruritus, diarrhea, abdominal pain, vomiting, high fever,...
This study aims to explore the active components and mechanism of Wuhu Decoction in treating respiratory syncytial virus(RSV)-induced asthma. Ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry was used determine blood. By utilizing databases, Kyoto Encyclopedia Genes Genomes(KEGG) enrichment analysis Gene Ontology(GO) functional were conducted investigate targets Furthermore, information on target proteins, metabolite-target-pathway imported into...
With the increase of environmental pollution and atypical pathogen infections, incidence cough variant asthma (CVA) has been increasing annually, making it a pressing issue medical community. This study aims to observe ameliorative effect curcumin on rat model asthma.
Children are highly susceptible to influenza and at high risk for severe cases. Chinese patent medicine (CPM) offers advantages in treating pediatric influenza, but the issue of its improper use is increasingly prevalent clinical practice. To address this, we adopted a dual leadership approach involving methodological experts, guided by evidence-based practice principles. We referred existing guidelines, consensus statements, treatment protocols, designed relevant questions based on “3...
BACKGROUND:This study analyzed the distribution of Rh serological phenotype in people living Hangzhou, China, and assessed necessity its routine clinical detection homotypic infusion. MATERIAL AND METHODS:Blood donors patients who might need blood transfusion were enrolled into study, ABO 5 major antigens (C, c, D, E, e) routinely detected. The consistent was transfused between recipients. Irregular antibodies screened identified before transfusion. Then, adverse effects monitored compared...
This study aimed to determine the effects of Xiebai Zengye decoction (XBZY) on airway inflammation and respiratory function in rats with postinfectious cough (PIC), its regulatory extracellular signal-regulated kinase (ERK) signaling pathway. Compared normal group, from PIC group had significantly shortened expiratory time (TE) enhanced pause (EEP), increased resistance (RT), (Penh), along levels serum interleukin-4 (IL-4) IL-6, decreased IL-10. The lung colon tissues showed...