A5101792008- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- NF-κB Signaling Pathways
- Tryptophan and brain disorders
- Natural product bioactivities and synthesis
- Saffron Plant Research Studies
- Toxin Mechanisms and Immunotoxins
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Hypoxia, and Metabolism
- Stress Responses and Cortisol
- Neurofibromatosis and Schwannoma Cases
- Neuroscience and Neuropharmacology Research
- HER2/EGFR in Cancer Research
- Cell death mechanisms and regulation
- Phytochemical compounds biological activities
- Moyamoya disease diagnosis and treatment
- Cell Adhesion Molecules Research
- Hedgehog Signaling Pathway Studies
- Head and Neck Cancer Studies
- interferon and immune responses
- Neuroendocrine regulation and behavior
- Wnt/β-catenin signaling in development and cancer
- Neurological disorders and treatments
Anhui Medical University
2015-2025
First Affiliated Hospital of Anhui Medical University
2024-2025
University of Science and Technology of China
2009-2024
Tongji University
2016-2023
Tongji Hospital
2016-2023
Weatherford College
2022
First Affiliated Hospital of University of South China
2018-2021
University of South China
2018-2021
CHI St. Vincent
2018-2021
St Vincent Medical Center
2018-2020
The citrus flavonoid hesperidin has been reported to possess a wide range of pharmacological properties. We have investigated the preventive and therapeutic effects on development adjuvant arthritis (AA), rat model rheumatoid (RA). Freund's complete was used induce AA in rats. Secondary paw swelling, polyarthritis index histopathological assessment ankle joints were evaluate Concanavalin-A-induced T-lymphocyte proliferation interleukin (IL)-2 production by splenocytes measured using MTT...
The popularity of flipped classroom (FC) is growing in medical education. However, the application FC pathology teaching has not been well explored. This study assessed efficacy combined with case-based learning (CBL) undergraduate education via comparison a traditional lecture-based (LBC).A total 117 third-year students were enrolled and assigned to group (n = 59) or LBC 58) demographic matches. Two sections textbook (cardiovascular respiratory system diseases) chosen for content. Students...
Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples Chinese banks. A total of 1142 brains six banks were examined using standardized methods. Independent pathologists conducted evaluations with stringent quality control. Prevalence and correlations neurological disorders analyzed. Significant proportions displayed primary age-related tauopathy (PART, 35%), limbic-predominant TDP-43 encephalopathy (LATE,...
Abstract Objectives We examined the antirheumatoid effects of piperlongumine (PLM) on rat adjuvant-induced arthritis (AIA) and explored underlying mechanisms involved. Methods PLM (2.5, 5, 10 mg/kg) was administered intraperitoneally to AIA rats assess its effectiveness. Blood, thymus, spleen, ankle joint, synovial tissue samples were gathered for subsequent analyses, like enzyme-linked immunosorbent assay, thymus/spleen index measurement, joint pathological examination, immunohistochemistry...
We investigated whether inhibition of hedgehog (Hh) signal by cyclopamine attenuated inflammation and cartilage damage in adjuvant-induced arthritis (AIA) rats.Cyclopamine (2.5, 5, 10 mg/kg) was given intraperitoneal injection once daily from day 12 to 21 after AIA induction. Paw swelling (volume changes), serum pro-inflammatory cytokines levels (ELISA), histological analysis joint (H&E staining), proteoglycans expression (Alcian blue mRNA sonic Hh (Shh), glioma-associated oncogene homologue...
Class III malocclusion is a maxillofacial disorder that characterised by concave profile and can be attributed to both genetic inheritance environmental factors. It clinical challenge due our limited understanding of its aetiology. Revealing prototypical diversity will contribute sequential exploration the underlying aetiological information. The objective this study was characterize phenotypic variations via lateral cephalometric analysis in community Chinese individuals....
Petroclival meningiomas (PCMs) are regarded as one of the most formidable challenges in neurosurgery. We retrospectively assessed surgical outcomes PCMs based on a tumor classification to evaluate long-term outcomes. A series 168 patients with from July 1996 January 2017. On basis difference origin dural attachment and patterns growth, were classified into 4 different types. The clinical characteristics, record, follow-up data each type reviewed. study included 138 females (82.1%) an average...
Abstract The present study was designed to investigate the effect of hesperidin on rat adjuvant arthritis (AA) and elucidate involvement synoviocytes in this process. Freund's complete used induce AA rats. Secondary paw swelling index immune organs rats were measured. Macrophage‐like separated by method collagenase trypsin digestion. Synoviocyte proliferation assayed MTT assay. TNF‐α, IL‐1β IL‐10 production examined with ELISA. levels IL‐1β, mRNA determined using RT‐PCR. It found that...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by pronounced inflammation and excessive synovial hyperplasia within affected joint. We previously reported 7, 3′-dimethoxy hesperetin (DMHP) as a highly anti-inflammatory active derivative of hesperidin showed apparent pro-apoptotic effect in vitro on fibroblast-like synoviocytes rats with adjuvant (AA), animal model RA. Here, we investigated the therapeutic effects DMHP apoptosis AA vivo. Paw swelling, index, TNF-α IL-1β...
The dysfunction of articular chondrocytes is a crucial step in rheumatoid arthritis (RA) pathogenesis while its molecular mechanisms are not fully known. This study was aimed to investigate the expression aquaporin 4 (AQP4) adjuvant-induced (AIA) rats and involvement AIA development.Thirty were divided into normal group (n = 15). Rat induced by intradermal injection complete Freund's adjuvant evaluated secondary paw swelling histological assessments on knee joint damage. Localization protein...
Objectives: Previous studies have shown that aquaporin 1 (AQP1) is up-regulated in synovium and cartilage of rheumatoid arthritis (RA) patients AQP1 may be involved joint swelling synovial inflammation. This study was aimed to investigate the potential therapeutic effect acetazolamide (AZ, an inhibitor) on rat adjuvant-induced (AIA) explore its related mechanisms.Materials methods: Rat AIA induced by complete Freund's adjuvant. The AZ evaluated secondary hind paw swelling, index, TNF-α IL-1β...
Umbelliferone (UMB), a natural coumarin compound, has been reported to possess anti-rheumatic effects on rheumatoid arthritis (RA) experimental models, but its potential role of UMB in regulating migration, invasion and inflammation RA fibroblast-like synoviocytes (FLS) remain unclear. Herein, MTT assay was performed confirm the non-cytotoxic concentrations (10, 20, 40[Formula: see text][Formula: text]M) treatment time (24[Formula: text]h) TNF-[Formula: text]-stimulated FLS (MH7A cells)...
Cartilage damage is a crucial step in rheumatoid arthritis (RA) disease progress while its molecular mechanisms are not fully understood. Here we investigated the expression of hedgehog (Hh) signal pathway articular cartilage adjuvant-induced (AIA) rats and possible pathological role damage.30 were divided into sham AIA group (n = 15). Complete Freund's adjuvant was used to induce AIA. Secondary paw swelling measured on day 10, 14, 18, 22 26 after induction. Rats sacrificed knee joints...
Background The prevalence of tuberculosis (TB) in low and middle-income countries is a significant public health social concern. TB common infectious disease caused by the Mycobacterium infection, which has widespread infection rate. Health care-seeking delay maybe one most important neglected risk factors for spread TB. Objectives aim this study was to understand situation among rural patients Hubei Province, explore its factors. Methods A total 1408 were surveyed using standard structured...