A5068855017- Effects and risks of endocrine disrupting chemicals
- Sperm and Testicular Function
- Heavy Metal Exposure and Toxicity
- Cell death mechanisms and regulation
- Carcinogens and Genotoxicity Assessment
- Genetic and Kidney Cyst Diseases
- Toxic Organic Pollutants Impact
- Renal and related cancers
- Reproductive Biology and Fertility
- Air Quality and Health Impacts
- Photosynthetic Processes and Mechanisms
- Selenium in Biological Systems
- CRISPR and Genetic Engineering
- Pesticide Exposure and Toxicity
- Cancer, Hypoxia, and Metabolism
- Noise Effects and Management
- Nanoparticles: synthesis and applications
- Trace Elements in Health
- Cannabis and Cannabinoid Research
- Circular RNAs in diseases
- Protist diversity and phylogeny
- Molecular Biology Techniques and Applications
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
- Animal Genetics and Reproduction
Huazhong University of Science and Technology
2009-2025
Wuhan University of Science and Technology
2013-2024
Oil Crops Research Institute
2019-2022
Chinese Academy of Agricultural Sciences
2019-2022
Ministry of Agriculture and Rural Affairs
2019-2022
Tongji Hospital
2022
Fifth Hospital In Wuhan
2022
Wuhan University
2022
East Carolina University
2021
Gansu Provincial Maternal and Child Health Hospital
2012-2021
Abstract Cadmium is one of the environmental and occupational pollutants its potential adverse effects on human health have given rise to substantial concern. causes damage male reproductive system via induction germ-cell apoptosis; however, underlying mechanism cadmium-induced toxicity in Leydig cells remains unclear. In this study, twenty mice were divided randomly into four groups exposed CdCl 2 at concentrations 0, 0.5, 1.0 2.0 mg/kg/day for consecutive weeks. Testicular injury, abnormal...
4-Nonylphenol (NP) is a ubiquitous environmental chemical with estrogenic activity. Our aim was to test the hypothesis that pubertal exposure NP leads testicular dysfunction. Herein, 24 7-week-old rats were randomly divided into four groups and treated (0, 25, 50, or 100 mg/kg body weight every 2 days for 20 consecutive days) by intraperitoneal injection. Compared untreated controls, parameters of sperm activation rate, curvilinear velocity, average path swimming velocity significantly lower...
Pod shattering resistance is an essential component to achieving a high yield, which substantial objective in polyploid rapeseed cultivation. Previous studies have suggested that the Arabidopsis JAGGED (JAG) gene key factor implicated regulatory web of dehiscence fruit. However, its role controlling pod oilseed rape still unknown. In this study, multiplex genome editing was carried out by CRISPR/Cas9 system on five homoeologs (BnJAG.A02, BnJAG.C02, BnJAG.C06, BnJAG.A07, and BnJAG.A08) JAG...
Acute lung injury (ALI), one of the most severe respiratory system diseases, is prevalent worldwide. Annexin A1 (AnxA1) an important member annexin superfamily, known for its wide range physiological functions. However, potential protective effect against lipopolysaccharide (LPS)-induced ALI remains unclear. Mice were divided into four groups: Sham, LPS + vehicle, 0.1 μg AnxA1, and 0.5 AnxA1. Lung was assessed through histopathology, pulmonary wet-to-dry (W/D) ratio, cell counting...
Brassica napus is the most important oil crop plant for edible and renewable energy source worldwide. Yield loss caused by pod shattering a main problem during B. harvest. In this study, six BnSHP1 two BnSHP2 homoeologs were targeted CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 (CRISPR-associated protein 9) genome editing system multiple SHP1 SHP2 mutated lines identified evaluating contribution pod-shattering resistance. Our data suggest that BnSHP1A09 probably...
One,1‐dichloro‐2,2 bis(p‐chlorophenyl) ethylene (p,p ′ ‐DDE), the major metabolite of 2,2‐bis(4‐Chlorophenyl)‐1,1,1‐trichloroethane (DDT), is a known persistent organic pollutant and male reproductive toxicant. It has antiandrogenic effect. However, mechanism by which p,p ‐DDE exposure causes toxicity remains unknown. In present study, rat Sertoli cells were used to investigate molecular involved in ‐DDE‐induced system. The results indicated that at over 30 μ M showed induction apoptotic...
Di(2-ethylhexyl) phthalate (DEHP), a plasticizer of synthetic polymers, is well-known endocrine disrupting chemical (EDC) and reproductive toxicant. Addressing the unclear mechanism DEHP-induced dysfunction, this study used GC-2spd cells to investigate molecular involved in toxicity male system. The results indicated that apoptotic cell death was significantly induced by DEHP exposure over 100 μM. Furthermore, treatment could induce oxidative stress involving decrease superoxide dismutase...
The diploid Brassica oleracea and allopolyploidy napus are predominant members of commonly consumed vegetables plant oil, respectively. B. mainly include Broccoli, Cauliflower, Cabbage, Brussels sprouts, Kohlrabi. complex genome structure gene function redundancy the main obstacles for stacking through traditional cross-breeding approach. To solve this problem, high-efficiency CRISPR/Cas9 genome-editing technologies have been established (Li et al., 2018). However, an open question is that...
ABSTRACT Formaldehyde is ubiquitous in the environment. It known to be a genotoxic substance. We hypothesized that reactive oxygen species (ROS) and lipid peroxidation are involved formaldehyde‐induced genotoxicity human lung cancer cell lines A549. To test this hypothesis, we investigated effects of antioxidant on A549 Cell Lines. exposure caused induction DNA–protein cross‐links (DPCs). Curcumin an important antioxidant. significantly increased malondialdehyde (MDA) levels, decreased...
One, 1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE), the major metabolite of 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT), is a known persistent organic pollutant (POPs) and male reproductive toxicant. However, mechanism by which p,p'-DDE exposure causes toxicity remains unknown. The objective this study was to elucidate some mechanisms involved in process, including mitochondria apoptosis pathway role phospholipid hydroperoxide glutathione peroxidase (PHGPx). Puberty SD rats...
Solid–liquid phase equilibrium and physicochemical properties (pH, nD, ρ) for the ternary system KCl + KH2PO4 H2O at (298.15 313.15) K were investigated by method of isothermal solution saturation Schreinemaker's wet residue. On basis experimental data, corresponding diagrams vs composition plotted. In diagrams, there are one eutonic point, two uninvariant curves, crystallization regions to KCl, KH2PO4. The show similar tendencies different temperatures. At each temperature, region is larger...
Abstract One,1‐dichloro‐2,2 bis(p‐chlorophenyl) ethylene ( p , '‐DDE), the major metabolite of 2,2‐bis(4‐chlorophenyl)‐1,1,1‐trichloroethane (DDT), is a known persistent organic pollutant and male reproductive toxicant. It has antiandrogenic effect. However, mechanism by which p' ‐DDE exposure causes toxicity remains unknown. To elucidate underpinning testicular effects '‐DDE, we sought to investigate apoptotic mRNA expression apoptosis‐associated genes in testis pubertal rats, including...
Cervical cancer is a serious public health problem in developing countries. We investigated possible risk factors for cervical rural areas of Wuhan China using matched case-control study with 33 women diagnosed and 132 healthy selected from the same area as controls. A questionnaire, which included questions about general demography conditions, environmental genetic factors, first sexual intercourse, marriage age, age at pregnancy, pregnancy child's female personal history, social...
Mammalian spermatogenesis is a well-organized process of cell development and differentiation. Meiosis expressed gene 1 (MEIG1) plays an essential role in the regulation spermiogenesis. To explore potential mechanisms MEIG1's action, yeast two-hybrid screen was conducted, several binding partners were identified; one them membrane occupation recognition nexus repeat containing 3 (MORN3). MORN3 mRNA only abundant mouse testis. In testis, Morn3 highly spermiogenesis stage. Specific anti-MORN3...
Background The prevalence of tuberculosis (TB) in low and middle-income countries is a significant public health social concern. TB common infectious disease caused by the Mycobacterium infection, which has widespread infection rate. Health care-seeking delay maybe one most important neglected risk factors for spread TB. Objectives aim this study was to understand situation among rural patients Hubei Province, explore its factors. Methods A total 1408 were surveyed using standard structured...