A5035837077- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Effects and risks of endocrine disrupting chemicals
- Breastfeeding Practices and Influences
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Development and Preterm Care
- Congenital Anomalies and Fetal Surgery
- Autophagy in Disease and Therapy
- Pediatric health and respiratory diseases
- Congenital gastrointestinal and neural anomalies
- Lung Cancer Research Studies
- Tissue Engineering and Regenerative Medicine
- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Health disparities and outcomes
- Cancer-related cognitive impairment studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Iron Metabolism and Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Cellular Mechanics and Interactions
- Tryptophan and brain disorders
- Histone Deacetylase Inhibitors Research
Huazhong University of Science and Technology
2010-2025
First Affiliated Hospital of Zhengzhou University
2024-2025
Leibniz-Forschungsinstitut für Molekulare Pharmakologie
2023
Northwestern Polytechnical University
2019-2020
Henan University of Science and Technology
2019
Wuhan Puai Hospital
2014
Nationwide Children's Hospital
2013-2014
The Ohio State University
2013
Xiamen University
2011
Chinese Academy of Fishery Sciences
2011
Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling and the catabolic turnover of macromolecules. How these janus-faced activities are regulated response to cellular nutrient status is poorly understood. We show here that lysosome morphology function reversibly controlled a nutrient-regulated lipid switch triggers conversion between peripheral motile mTOR complex 1 (mTORC1) signaling-active static mTORC1-inactive degradative lysosomes clustered at cell...
Intestinal dysmotility following human necrotizing enterocolitis suggests that the enteric nervous system is injured during disease. We examined intestinal specimens to characterize injury occurs in enterocolitis, and then used an animal model of experimental determine whether transplantation neural stem cells can protect from injury. Human resected patients with (n = 18), control bowel atresia 8), undergoing stoma closure several months later 14 n 6 respectively) were subjected histologic...
In recent years, the incidence of patients with colorectal neuroendocrine neoplasms (CRNENs) has been continuously increasing. When diagnosed, most have distant metastases. Liver metastasis (LM) is common type metastasis, and prognosis poor once it occurs. However, there still a lack large studies on risk LM in CRNENs. This study aims to identify factors related develop predictive model accordingly. this study, Surveillance, Epidemiology, End Results (SEER) database was used collect clinical...
Abstract Background Necrotizing enterocolitis (NEC) is a leading gastrointestinal condition in preterm infants, characterized by significant morbidity and mortality. Early recognition of risk factors crucial for its prevention prediction. This study focuses on identifying that contribute to the development NEC neonates. Methods A case-control looked back at 144 newborns hospitalized Wuhan hospital between January 2010 March 2023 was carried out. Over same period, another children without...
Osteosarcoma cellular iron concentration is higher than that in normal bone cells and other cell types. High levels of help catalyze the Fenton reaction to produce reactive oxygen species (ROS), which promotes cancer proliferation. Dihydroartemisinin (DHA), a classic anti-malarial drug, kills plasmodium through iron-dependent ROS generation. In this research, we observed anti-osteosarcoma effects mechanisms DHA. We found DHA induced production, caused mitochondrial damage, activated...
Background: Hepcidin encoded by HAMP is vital to regulating proliferation, metastasis, and migration. secreted specifically the liver. This study sought examine functional role of hepcidin in hepatocellular carcinoma (HCC). Methods: Data Cancer Genome Atlas database was used analyze expression as it relates HCC prognosis. We then 5-ethynyl-20-deoxyuridine (EdU) incorporation assay, transwell flow cytometric analysis, respectively, assess migration, cell cycle. Gene set enrichment analysis...
Restitution is a critical form of intestinal epithelial cell (IEC) healing. We have previously shown that heparin-binding epidermal-like growth factor (HB-EGF) necessary for IEC restitution; however, the mechanisms by which HB-EGF promotes restitution remain poorly understood. This study was designed to investigate whether affecting integrin–extracellular matrix (ECM) interactions and intercellular adhesions. The effect administration examined in murine necrotizing enterocolitis (NEC) model...
Human milk (HM) has been associated with a lower risk of necrotizing enterocolitis (NEC). However, the association precise HM proportion outcome NEC remains unclear. A total 77 cases and 154 matched controls were included in this study. The samples divided into three groups based on enteral intake before onset: ≥70% (HHM), <70% (LHM), 0% (NHM). study cohort did not show significant between different proportions risk. adjusted odds ratio (OR) for highest versus lowest was 0.599. In...
Throughout the past 20 years, we have been investigating potential therapeutic roles of heparin-binding EGF-like growth factor (HB-EGF), a member epidermal family, in various models intestinal injury including necrotizing enterocolitis (NEC), ischemia/reperfusion (I/R) injury, and hemorrhagic shock resuscitation (HS/R). Our studies demonstrated that HB-EGF acts as an effective mitogen, restitution-inducing reagent, cellular trophic factor, anti-apoptotic protein vasodilator, via its effects...
Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase activating polypeptide (PACAP) regulate development somatic growth in teleosts; they may be associated with sexual dimorphism the half-smooth tongue sole (Cynoglossus semilaevis).We found that full-length GHRH PACAP gene sequences obtained from females males consist of 4160, 4159, 2425, 2446 bp, respectively, each which includes four exons three introns.When we analyzed normal extra-large male adults, mRNA were to...
Biliary innervation is considered important in regulating the function of bile ducts, whereas role hepatobiliary system patients with biliary atresia (BA) remains unknown. This current study aims to investigate remnants and analyze relationship between prognosis BA after surgery.
Pulmonary inflammation and progressive lung destruction are the major causes of chronic obstructive pulmonary disease (COPD), resulting in emphysema irreversible dysfunction. Heparin-binding EGF-like growth factor (HB-EGF), is known to play a protective role process various inflammatory diseases. However, its effect on COPD poorly understood. This study was designed determine HB-EGF injury murine model emphysema. promoted percent survival body weight, attenuated injury, cells, cytokines...
Community-based blood pressure (BP) monitoring plays an important role in national hypertension management China. However, the utilisation of this service, together with its associations on treatment and BP control has not been fully investigated. The study population was from China Health Retirement Longitudinal Study (CHARLS) 2015. Cross-sectional data 2487 hypertensive persons were included as subjects. Stratified sample households selected 450 villages or communities 150 counties 28...
Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As HHEX is a recognized gene in T2DM, this work was focused on two SNPs HHEX, rs1111875 and rs7923837, study their association with CRC. without (T2DM-only, n=300), (T2DM/CRC, n=135), cancer-free controls (Control, n=570), (CRC-only, n=642) cases were enrolled. DNA samples extracted from the peripheral blood leukocytes sequenced by direct...