A5101731437- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Tuberculosis Research and Epidemiology
- Effects and risks of endocrine disrupting chemicals
- Cancer-related Molecular Pathways
- Neuropeptides and Animal Physiology
- Glutathione Transferases and Polymorphisms
- Diet and metabolism studies
- Trace Elements in Health
- Medicinal Plants and Neuroprotection
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Graphene and Nanomaterials Applications
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Infant Health and Development
- Exercise and Physiological Responses
- Adenosine and Purinergic Signaling
- Spinal Cord Injury Research
- Autophagy in Disease and Therapy
- Nicotinic Acetylcholine Receptors Study
- Sirtuins and Resveratrol in Medicine
- Mycobacterium research and diagnosis
- Health, Environment, Cognitive Aging
- Genomics, phytochemicals, and oxidative stress
Shenzhen Third People’s Hospital
2024-2025
Shaoxing People's Hospital
2023-2025
Xinjiang University
2025
Gansu University of Traditional Chinese Medicine
2024
Southern University of Science and Technology
2018-2023
Harbin Institute of Technology
2021-2023
Shaoxing University
2023
Shenzhen Center for Disease Control and Prevention
2014-2019
University at Buffalo, State University of New York
2016-2018
In-Q-Tel
2016
Pulmonary fibrosis (PF) is a terminal change of lung disease that marked by damage to alveolar epithelial cells, abnormal proliferative transformation fibroblasts, excessive deposition extracellular matrix (ECM), and concomitant inflammatory damage. Its characteristics include short median survival, high mortality rate, limited treatment effectiveness. More in-depth studies on the mechanisms PF are needed provide better options. The idea gut-lung axis has emerged as result comprehensive...
Di(2-ethylhexyl) phthalate (DEHP) is reported to cause obesity and hypothyroidism in both humans rodents, but the underlying mechanisms were largely unknown. This study was designed clarify effects of DEHP on pathogenesis discover relationship between them.Male C3H/He mice treated with for 5 weeks, body weight, food intake, temperature recorded during exposure. After exposure, key organs serum analyzed by Q-PCR, Western blot, ELISA.DEHP induced significant weight gain adipogenesis all...
This study explores the association between serum chloride concentrations and all-cause mortality among patients in Surgical Intensive Care Unit (SICU). Employing a retrospective cohort design, utilized data extracted from Medical Information Mart for IV (MIMIC-IV) database, specifically focusing on individuals admitted to surgical/trauma ICUs. dataset encompassed demographic profiles, laboratory findings, historical medical data, vital statistics, variables pertinent prognosis. Participants...
Flexible wearable electronic devices have found widespread applications in health monitoring and human–machine interaction. Piezoelectric sensors, capable of converting mechanical stress into electrical signals, serve as critical components these systems. In this study, we enhanced the piezoelectric performance PVDF-based composite materials through MoS2 incorporation. Experimental results demonstrated that addition effectively increased β-phase content PVDF, achieving a maximum value 70.0%...
Abstract Soy protein isolate (SPI) is a widely used food ingredient and made by extracting soy flour (SF) under slightly alkaline pH, followed precipitation, washing, drying. foods containing ingredients have great potential in the prevention of cardiovascular diseases cancers. These health benefits been attributed to isoflavones ingredients. However, current processing techniques were developed many years ago without this knowledge. The objective study was investigate mass balance different...
A nationwide survey of hepatitis B virus (HBV)-associated economic burden has not previously been performed in China. The purpose this study was to examine the direct, indirect, and intangible costs HBV-related diseases within span one year. random sample taken from specialty general hospitals across 12 cities six provinces Intangible were estimated based on willingness pay or open-ended answers provided by patients. results showed that 27 enrolled, with a population 4726 patients (77.7%...
Background: Irritable bowel syndrome (IBS) is a functional disorder characterized by abdominal pain and abnormalities in defecation associated with psychiatric disorders such as depression anxiety due to the dysfunction of brain-gut axis. This study aims determine whether trans-Resveratrol affects chronic-acute combined stress (CACS)-induced IBS-like symptoms including depression, intestinal dysfunction. Methods: ICR male mice were exposed CACS for 3 weeks. administrated daily (2.5, 5, 10...
Alzheimer's disease (AD) is the most common neurodegenerative characterized by a progressive impairment of cognitive functions including spatial learning and memory. Excess copper exposure accelerates development AD; however, poten
Copper is an essential element for human growth and development; however, excessive intake of copper could contribute to neurotoxicity. Here we show that chronic exposure in drinking water impaired spatial memory with simultaneous selective
Mechanical allodynia (MA) represents one prevalent symptom of chronic pain. Previously we and others have identified spinal brain circuits that transmit or modulate the initial establishment MA. However, brain-derived descending pathways control laterality duration MA are still poorly understood. Here report contralateral brain-to-spinal circuits, from Oprm1 neurons in lateral parabrachial nucleus (lPBNOprm1), via Pdyn dorsal medial regions hypothalamus (dmHPdyn), to horn (SDH), act prevent...
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen capable of adapting and surviving within macrophages, utilizing host nutrients for its growth replication. Cholesterol the main carbon source during infection process Mtb. metabolism in macrophages tightly associated with cell functions such as phagocytosis pathogens, antigen presentation, inflammatory responses, tissue repair. Research has shown that Mtb increases uptake low-density lipoprotein (LDL) cholesterol by enhances de...
The objective of this study is to determine testicular pathological damage and explore its molecular mechanisms after di-2-ethylhexyl phthalate (DEHP) treatment.
Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase activating polypeptide (PACAP) regulate development somatic growth in teleosts; they may be associated with sexual dimorphism the half-smooth tongue sole (Cynoglossus semilaevis).We found that full-length GHRH PACAP gene sequences obtained from females males consist of 4160, 4159, 2425, 2446 bp, respectively, each which includes four exons three introns.When we analyzed normal extra-large male adults, mRNA were to...
// Xiaoyu Pan 1, * , Jiechun Chen 2, Weijie Wang 3, Ling 4 Lin Quan Ma 5 Jianbo Zhang 6 Lichao 7 Gang Meixi 7, # Hao Wu 8, Ruochuan Cheng 1 Department of Thyroid Surgery, The First Affiliated Hospital Kunming Medical University, Kunming, Yunnan Province, China 2 Neurology, Lianyungang second people’s Hospital, Lianyungang, Jiangsu 3 Neurosurgery, Huai’an People’s Nanjing Huai’an, Clinical Pharmacy, Hangzhou Hangzhou, Zhejiang Pharmaceutical Sciences, School Pharmacy...
The central nervous system (CNS) harbors its own special immune composed of microglia in the parenchyma, CNS-associated macrophages (CAMs), dendritic cells, monocytes, and barrier systems within brain. Recently, advances cells CNS provided new insights to understand development tuberculous meningitis (TBM), which is predominant form Mycobacterium tuberculosis ( M.tb ) infection accompanied with high mortality disability. requires protection including microglia, during embryogenesis ensure...
Alzheimer's disease (AD) is the most common fatal neurodegenerative affecting elderly worldwide. There an urgent need to identify novel biomarkers of early AD. This study aims search for potential protein in serum from a triple transgenic (PS1M146V/APPSwe/TauP301L) mouse model. Proteomic analysis via two-dimensional fluorescence difference gel electrophoresis was performed on samples wild-type (WT) and mice that were treated with or without coenzyme Q10 (CoQ10) (800 mg/kg body weight/day),...
Recent studies suggest that copper exposure, even at very low levels, can produce significant toxic effects on the brains of mice. This study is aimed to explore levels hippocampal proteome Two-dimensional fluorescence difference gel electrophoresis was performed homogenate obtained from mice, which were given either drinking water only (control) or supplemented with 0.13 ppm (copper-treated) for a period 8 months beginning an age 3 months. A total 9 differentially expressed proteins between...
Copper is an essential element for human growth and development; however, excessive intake of copper could contribute to neurotoxicity. The effects chronic exposure on spatial memory the possible mechanisms remain unclear. Inductively coupled plasma mass spectrometry (ICP-MS) was used measure concentrations in serum hippocampus mice. Morris water maze test performed evaluate learning memory. Immunohistochemical staining Western-blot analysis were changes oxidative stress markers, synaptic...
<title>Abstract</title> This study aims to explore the correlation between serum chloride levels and all-cause mortality among patients in Surgical Intensive Care Unit (SICU).A retrospective cohort was conducted using data extracted from Medical Information Mart for IV (MIMIC-IV) database, focusing on admitted surgical/trauma ICUs. Data included demographic information, laboratory results, medical history, vital signs, prognosis-related variables. Patients were categorized into four groups...