A5011049198- Pharmaceutical and Antibiotic Environmental Impacts
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Biosensors and Analytical Detection
- Carcinogens and Genotoxicity Assessment
- Analytical Chemistry and Chromatography
- Pesticide Residue Analysis and Safety
- Mycotoxins in Agriculture and Food
- Nutritional Studies and Diet
- Veterinary medicine and infectious diseases
- Air Quality and Health Impacts
- Pharmacological Effects and Assays
- Heavy Metal Exposure and Toxicity
- Analytical chemistry methods development
- Liver Disease Diagnosis and Treatment
- Insect and Pesticide Research
- Microbial infections and disease research
- Toxic Organic Pollutants Impact
- Salmonella and Campylobacter epidemiology
- Trace Elements in Health
- Mass Spectrometry Techniques and Applications
- Cancer Risks and Factors
- Circular RNAs in diseases
Shaoxing People's Hospital
2024
Shenzhen Center for Disease Control and Prevention
2014-2023
Shenzhen University
2021
Peking University
2018-2020
Peking University People's Hospital
2018-2020
Shenzhen University Health Science Center
2018
Southern Medical University
2015
Zhujiang Hospital
2015
Centers for Disease Control and Prevention
2010-2015
Huazhong University of Science and Technology
2009
Ischemic stroke (IS) is a major cause of morbidity and mortality globally. Environmental exposure to metals may be linked the risk IS, but association remains uncertain in Chinese populations. The present study aimed examine associations between concentrations 11 (aluminum, arsenic, cadmium, cobalt, copper, iron, manganese, molybdenum, selenium, thallium, zinc) plasma IS population. A total 1277 pairs newly diagnosed patients controls matched on age (±3 years) sex were recruited our study....
Elevated levels of S-adenosylhomocysteine (SAH), the precursor homocysteine, are positively associated with risk cardiovascular disease and development progression atherosclerosis. However, role SAH in endothelial dysfunction is unclear.Apolipoprotein E-deficient ( apoE-/-) mice received dietary supplementation hydrolase (SAHH) inhibitor adenosine dialdehyde or were intravenously injected a retrovirus expressing SAHH shRNA. These 2 approaches, along heterozygous gene knockout SAHH+/-) mouse...
Cumulative research on resistomes and microbiomes from aquatic environments has revealed that both integrated freshwater monoculture aquaculture systems can cause the development dissemination of antibiotic resistance genes (ARGs) associated mobile genetic elements (MGEs). However, few studies have examined differences in between different modes, those do focused residues or individual genes. In current study, we collected 44 environmental samples two farms four (two duck fish farms, laying...
As several vaccines for SARS-CoV-2 have been developed, a large proportion of individuals vaccinated worldwide so far. The rapid and accurate immunoassays are urgently needed detecting the specific virus-neutralizing antibody (NAb), which reflect protective effect among different populations.In this study, we designed quantum dot lateral flow immunoassay strip (QD-LFIA) smartphones detection IgG or neutralizing antibodies in human serum whole blood samples. recombinant receptor binding...
Di(2-ethylhexyl) phthalate (DEHP) is reported to cause obesity and hypothyroidism in both humans rodents, but the underlying mechanisms were largely unknown. This study was designed clarify effects of DEHP on pathogenesis discover relationship between them.Male C3H/He mice treated with for 5 weeks, body weight, food intake, temperature recorded during exposure. After exposure, key organs serum analyzed by Q-PCR, Western blot, ELISA.DEHP induced significant weight gain adipogenesis all...
The rapid dissemination of the macrolide resistance gene erm(B) will likely compromise efficacy macrolides as treatment choice for campylobacteriosis. More importantly, is always associated with several multidrug genomic islands (MDRGIs), which confer to multiple other antimicrobials. Continuous monitoring emergence and analysis its genetic environments are crucial our understanding in Campylobacter In this study, 290 isolates (216 coli 74 jejuni isolates) were obtained from 1,039 fecal...
microRNA (miRNA) plays a role in the pathogenesis of ischemic stroke, and single nucleotide polymorphisms miRNA genes may contribute to disease susceptibility. However, effect miR-146a, miR-196a2, miR-499 on stroke susceptibility has been rarely reported. Using TaqMan assay, we evaluated association hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913, hsa-miR-499/rs3746444 with risk Chinese population 531 patients control subjects. Rs2910164 C/G genotypes were significantly associated increased...
Abstract Objective: Previous studies have reported inverse associations between certain healthy lifestyle factors and non-alcoholic fatty liver disease (NAFLD), but limited evidence showed the synergistic effect of those lifestyles. This study examined relationship a combination lifestyles, expressed as Healthy Lifestyle Score (HLS), with NAFLD. Design: A community-based cross-sectional study. Questionnaires body assessments were used to collect data on six-item HLS (ranging from 0 6, where...
Previous investigations have indicated that cooks are exposed to polycyclic aromatic hydrocarbons (PAHs) from cooking-oil fumes. However, Emission of PAH and their carcinogenic potencies cooking oil fumes sources not been investigated among cooks. To investigate the urinary excretion a marker for oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), in different groups exposure groups, study association between 8-OHdG 1-hydroxypyrene(1-OHP), biological exposure. Urine samples were...
Abstract Context and Objective This case control study was designed to investigate the association between mutation of 10 single nucleotide polymorphism (SNP) loci (rs1132506, rs5780218, rs192636495, rs4889, rs184749, rs12985070, rs708910, rs932491, rs8074995, rs2306877) in all 5 genes (KISS1, GPR54, PLCB1, PRKCA, ITPR1) kisspeptin/GPR54 pathway risk early puberty Chinese Han girls. Design Participants A total 314 pairs girls on their first visit hospital age-matched controls (± 3 months)...
Background: The association between serum vitamin A and non-alcoholic fatty liver disease (NAFLD) remains uncertain due to inconsistent results scarce longitudinal data. We examined the prospective associations evolution of NAFLD severity score as well potential mediating effects in middle-aged older Chinese adults. Method: total 2658 adults (between 40-75 years age) were included analysis. determined concentrations at onset study (the baseline), degree after 3 6. Results: Subjects...