A5038432790- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 detection and testing
- Advanced Biosensing Techniques and Applications
- Plasmonic and Surface Plasmon Research
- Advanced Fiber Optic Sensors
- SARS-CoV-2 and COVID-19 Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Photonic and Optical Devices
- Advanced Chemical Sensor Technologies
- MicroRNA in disease regulation
- Burkholderia infections and melioidosis
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- Hemoglobinopathies and Related Disorders
- Erythropoietin and Anemia Treatment
- Advanced Nanomaterials in Catalysis
- Psoriasis: Treatment and Pathogenesis
- Ionic liquids properties and applications
- Parvovirus B19 Infection Studies
- bioluminescence and chemiluminescence research
- Bacterial Identification and Susceptibility Testing
- Electrochemical Analysis and Applications
- Mercury impact and mitigation studies
General Hospital of Shenyang Military Region
2024
Southern Medical University
2020-2023
Nanfang Hospital
2022-2023
First Affiliated Hospital of Jinan University
2019
Jinan University
2015-2018
Key Laboratory of Guangdong Province
2016
Charité - Universitätsmedizin Berlin
2013
Wuhan University
2012
Renmin Hospital of Wuhan University
2012
We propose and demonstrate hydrogen peroxide (H2O2) glucose concentration measurements using a plasmonic optical fiber sensor. The sensor utilizes tilted Bragg grating (TFBG) written in standard single mode communication fiber. is over coated with an nm-scale film of silver that supports surface plasmon resonances (SPRs). Such SPR structure provides high density narrow spectral (Q-factor about 105) overlap the broader absorption band waves film, thereby providing accurate tool to measure...
We present an optical fiber biosensor that employs both long-range and localized surface plasmon resonances (SPRs) to sensitively detect very small changes in the due surrounding refractive index. A tilted Bragg grating inscribed standard single-mode couples light into fiber's cladding, where it induces micrometer-scale SPRs a 50-nm-thick gold coating. The limit of detection targeted protein, thrombin, is enhanced by resonance between induced 13-nm-diameter nanoparticles bonded via aptamers...
As several vaccines for SARS-CoV-2 have been developed, a large proportion of individuals vaccinated worldwide so far. The rapid and accurate immunoassays are urgently needed detecting the specific virus-neutralizing antibody (NAb), which reflect protective effect among different populations.In this study, we designed quantum dot lateral flow immunoassay strip (QD-LFIA) smartphones detection IgG or neutralizing antibodies in human serum whole blood samples. recombinant receptor binding...
There is a high global demand for sensitive, portable, user-friendly, and cost-effective biosensors. In this work, we introduce barometer-based biosensor the detection of broad range targets. The device operated by measuring pressure change produced oxygen (O2) generation in limited chamber using portable barometer. design employs core-shell Au@Pt nanoparticles (Au@PtNPs) as bioassay probe to catalyze decomposition H2O2 release O2. As proof concept, developed immunosensors detect...
Immunochromatographic sensors (ICSs) are inexpensive, simple, portable, and robust, thus making ICSs commonplace in clinical diagnoses, food testing, environmental monitoring. However, commonly used gold nanoparticles (AuNPs) have low sensitivity. Therefore, we developed highly sensitive surface enhanced Raman scattering (SERS) ICSs. To enhance the sensitivity of SERS ICSs, rough core–shell Au@Ag (RSAu@AgNPs) were prepared by coating silver on nanoflowers (AuNFs). Then these as substrate...
The titer of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies (NAbs) in the human body is an essential reference for evaluating acquired protective immunity and resistance to SARS-CoV-2 infection. In this study, a fluorescence-quenching lateral flow immunoassay (FQ-LFIA) established quantitative detection anti-SARS-CoV-2 NAbs sera individuals who are vaccinated or infected within 10 min. ultrabright aggregation-induced emission properties encapsulated...
A smart phone-based PNRP operates by measuring the intensity of transmitted light using ambient sensor a phone.
During intrauterine development, the formation and function of synaptic vesicles (SVs) are thought to be fundamental conditions essential for normal development brain. Lacking advanced technology during period, such as longitudinal real-time monitoring SV-associated transcripts (SVATs), which include six pairs lncRNA-mRNA, has limited acquisition dynamic gene expression profile (GEP) SVATs. We previously reported differential SVATs in peripheral blood autistic children. The current study was...
To control the coronavirus disease 2019 (COVID-19) pandemic, there is an urgent need for simple, rapid, and reliable detection methods to identify severe acute respiratory syndrome 2 (SARS-CoV-2) infection, especially in community hospitals or clinical centers. The SARS-CoV-2 nucleocapsid protein (NP) important index diagnosis of COVID-19. Here, we proposed a smartphone-based high-throughput fiber-integrated immunosensing system (HFIS) detecting NP serum samples within 45 min. For testing...
The systemic immune inflammation index (SII) is an effective indicator of inflammatory status. As psoriasis patients present with involvement, we assessed whether SII associated in adults. We used data from the National Health and Nutrition Examination Survey (NHANES) 2003 to 2006 2009 2014. study a multistage sampling design that nationally represents US population. main outcome was prevalence psoriasis. calculated as platelet count × neutrophil count/lymphocyte transformed into log2SII....
The portable detection system based on a smartphone readout device is potential tool for environmental monitoring.
Since December 2019, a novel coronavirus (SARS-CoV-2) has resulted in global pandemic of disease (COVID-19). Although viral nucleic acid test (NAT) been applied predominantly to detect SARS-CoV-2 RNA for confirmation diagnosis COVID-19, an urgent need alternative, rapid, and sensitive immunoassays is required primary screening virus. In this study, we developed smartphone-based nanozyme-linked immunosorbent assay (SP-NLISA) detecting the specific nucleocapsid phosphoprotein (NP) 37 serum...
Since Epstein-Barr virus (EBV) was discovered in 1964, it has been reported to be associated with various malignancies as well benign diseases, and the pathogenicity of EBV widely studied. Several databases have established provide comprehensive information on its relation diseases introduce convenient analysis tools. Although they greatly facilitated at genome, gene, protein, or epitope level, did not enough insight into genomic variants EBV, which suggested relevant by multiple studies....
Immunochromatographic strips (ICSs) are a practical tool commonly used in point-of-care testing (POCT) applications. However, ICSs that currently available have low sensitivity and require expensive equipment for quantitative analysis. These limitations prohibit their extensive use areas where medical resources scarce.We developed novel POCT platform by integrating gas generation biosensor with Au@Pt Core/Shell nanoparticle (Au@PtNPs)-based (G-ICSs). The resulting G-ICSs enabled the...
ABSTRACT Background Since December 2019, the outbreak of coronavirus disease (COVID-19) has been occurred by novel (SARS-CoV-2). The rapid and sensitive immunoassays are urgently demanded for detecting specific antibodies as assistant diagnosis primary screening asymptomatic individuals, close contacts, suspected or recovered patients COIVD-19 during pandemic period. Methods recombinant receptor binding domain SARS-CoV-2 spike protein (S-RBD) was used antigen to detect IgM mixture...