A5101487366- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Chromatography in Natural Products
- Advanced Chemical Sensor Technologies
- Advanced biosensing and bioanalysis techniques
- Genetic factors in colorectal cancer
- Ionic liquids properties and applications
- Analytical chemistry methods development
- Traditional Chinese Medicine Analysis
- Health, Environment, Cognitive Aging
- Biosensors and Analytical Detection
- Hormonal and reproductive studies
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Digestive system and related health
- Advanced Nanomaterials in Catalysis
- Cancer, Lipids, and Metabolism
- Protein purification and stability
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Ion-surface interactions and analysis
Dalian Institute of Chemical Physics
2016-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2019-2024
Dalian University of Technology
2001-2024
Institute of Soil Science
2015
North China Institute of Aerospace Engineering
2015
Dalian University
2001-2014
Kunming Medical University
2013
Stomatology Hospital
2013
Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical and related risks. For this study, we collected serum samples from 5696 healthy people patients, including those with 12 in China completed biomonitoring 267 chemicals via gas liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected were used for exposure characterization risk analysis. The results show...
As a typical chronic inflammatory joint disease with swelling and pain syndromes, rheumatoid arthritis (RA) is closely related to articular lubrication deficiency excessive proinflammatory cytokines in its progression pathogenesis. Herein, inspired by the dual effects of improvement anti-inflammation treat RA, two novel potential therapeutic nanoagents have been developed rationally employing herbal medicine-derived carbon quantum dots (CQDs), i.e., safflower (Carthamus tinctorius L.) CQDs...
Ribosylated metabolites, especially modified nucleosides, have been extensively evaluated as cancer-related biomarkers. Boronate adsorbents are considered to be promising materials for extracting them from complex matrices. However, the enrichment of ribosylated metabolites in low abundance is still a challenge due limited capacity and selectivity existing boronate adsorbents. In this study, novel type magnetic nanoparticles named Fe3O4@SiO2@PEI-FPBA was synthesized by grafting...
Bisphenol A (BPA), a chemical widely used in the manufacture of polycarbonate plastics, has raised considerable concern recent decades because its hormone-like properties. Whether BPA exposure is health risk remains controversial many countries. metabolomics study based on capillary electrophoresis time-of-flight mass spectrometry (CE-TOF/MS) was performed to urine metabolic profiles Sprague–Dawley rats fed with four dose levels (0, 1, 10, and 100 μg/kg body weight) for 45 days. Multivariate...
High-coverage mass spectrometry analysis of single-cell metabolomics remains challenging due to the extremely low abundance and wide polarity metabolites ultra-small volume in single cells. Herein, a novel concentric hybrid ionization source, nanoelectrospray ionization-atmospheric pressure chemical (nanoESI-APCI), is ingeniously designed detect polar nonpolar simultaneously The source constructed by inserting pulled glass capillary coaxially into tube that acts as dielectric barrier layer....
Abstract Lung cancer is one of the most common and lethal cancers in world. In this study, a home‐devised hydrophilic interaction chromatography/RPLC‐MS (HILIC/RPLC‐MS) system was developed to study urinary metabonomics lung patients. This combined orthogonal selectivity HILIC RPLC could chromatographically reveal more comprehensive information metabolites. Within total analysis time 50 min, we detected 577 polar metabolite ions on first column 261 apolar ones second column. addition, an...
Metabolite and lipid profilings usually need two liquid chromatography-mass spectrometry (LC-MS) methods because of a great polarity difference. A pseudotargeted metabolomics method as novel emerging approach can integrate the advantages nontargeted targeted methods. Here, we aim to establish comprehensive for metabolome lipidome by using parallel column-based two-dimensional LC (PC-2DLC)-MS approach. To simultaneously extract many polar metabolites nonpolar lipids possible, systematically...
<title>Abstract</title> Metabolome-exposome association studies (mEWAS) demands high-coverage and high-sensitivity analytical methods for metabolites exposures with diverse chemical properties concentrations. Here, we present an integrated column-switching two-dimensional liquid chromatography (2DLC) - high resolution/triple quadrupole dual mass spectrometry (MS) method, achieving simultaneously untargeted metabolome targeted exposome analyses including 598 in a single run. Polar non-polar...