A5004303362- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Pesticide Residue Analysis and Safety
- Analytical chemistry methods development
- Molecular Sensors and Ion Detection
- Advanced Biosensing Techniques and Applications
- Pharmacological Effects and Assays
- Quantum Dots Synthesis And Properties
- Catalysts for Methane Reforming
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Insect and Pesticide Research
- Metamaterials and Metasurfaces Applications
- Photoreceptor and optogenetics research
- Plasmonic and Surface Plasmon Research
- Electrochemical Analysis and Applications
- Synthesis and Properties of Aromatic Compounds
- Luminescence and Fluorescent Materials
- Carbon and Quantum Dots Applications
- Catalysis and Hydrodesulfurization Studies
State Key Laboratory of Food Science and Technology
2016-2025
Jiangnan University
2016-2025
Northeast Petroleum University
2024
North China Electric Power University
2022
State Council of the People's Republic of China
2015-2021
BioSurfaces (United States)
2017-2021
Ministry of Education of the People's Republic of China
2019
Wuxi People's Hospital
2015
University of Michigan–Ann Arbor
2010
University of Kentucky
1993-2000
Abstract Nanoscale plasmonic assemblies display exceptionally strong chiral optical activity. So far, their structural design was primarily driven by challenges related to metamaterials whose practical applications are remote. Here we demonstrate that gold nanorods assembled the polymerase chain reaction into DNA-bridged systems have promising analytical applications. The chiroplasmonic activity of side-by-side patterns is attributed a 7–9 degree twist between nanorod axes. This results in...
Chiral self-assembled nanomaterials with biological applications have attracted great interest. In this study, DNA-driven gold-upconversion nanoparticle (Au-UCNP) pyramids were fabricated to detect intracellular microRNA (miRNA) in real time. The Au-UCNP are doubly optically active, displaying strong plasmonic circular dichroism (CD) at 521 nm and significant luminescence 500-600 nm, therefore can be monitored by both of them. CD will decrease while the intensity increases presence miRNA....
Chirality at the nanometer scale represents one of most rapidly developing areas research. Self-assembly DNA-nanoparticle (NP) hybrids enables geometrically precise assembly chiral isomers. The concept a discrete nanostructure tetrahedral shape and topology fabricated from four different NPs located in corners pyramid is fundamental to field. While first observations optical activity mixed pyramidal assemblies were made 2009 (Chen, W.; Nano Lett. 2009, 9, 2153-2159), further studies are...
Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is one of the major pathological mechanisms Parkinson's disease. Using inorganic nanomaterials to scavenge ROS has drawn significant interest and can prevent ROS-mediated neurological disorders. We prepared uniform CuxO nanoparticle clusters (NCs) with an average size 65 ± 7 nm, using phenylalanine (Phe) as structure-directing agent. These NCs functionally mimicked activities peroxidase, superoxide dismutase, catalase,...
Chiral assemblies of nanoparticles (NPs) are typically constructed with helical or tetrahedral geometries. Simple pairs NPs not expected to display chirality due basic symmetry considerations made under the assumption their spherical geometry. In this study we demonstrate that consisting two metallic do possess and strongly rotate polarization light. Their chiroplasmonic properties attributed prolate geometry individual colloidal particles. When bridged by biomolecules, NP acquire...
Three disease biomarkers can simultaneously be detected at the attomolar level because of a novel surface-enhanced Raman scattering (SERS) encoded silver pyramid sensing system. This newly designed pyramidal sensor with well-controlled geometry exhibits highly sensitive, selective, and reproducible SERS signals, holds promising potential for biodetection applications. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer...
The development of a unique and universal strategy for the simultaneous quantification different types biomolecules (i.e., nucleic acids proteins) in living cells is extremely challenging. Herein, two-signal platform, based upon surface-enhanced Raman scattering upconversion, ultrasensitive quantitative situ detection microRNA (miR)-21 telomerase reported. In presence miR-21 telomerase, hybridization with molecular beacon leads to separation 3,3'-diethylthiocarbamyl cyanine iodide-modified...
Multiple properties of plasmonic assemblies are determined by their geometrical organization. While high degree complexity was achieved for superstructures based on nanoparticles (NPs), little is known about the stable and structurally reproducible made up from geometrically diverse building blocks. Among other possibilities, they open door preparation regiospecific isomers nanoscale significant both a fundamental point view optical applications. Here, we present synthetic method complex NPs...
Parallel or angle parked: Gold nanorods (see picture) were selectively modified either on the sides ends using complementary microcystin (MC-LR) antibody and antigen (blue). Fast detection of MC-LR (green) was successfully achieved with these assemblies, both sensitivity ranges markedly better for end-to-end motif (right) than side-to-side variant (left). Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...
DNA-driven hierarchical core–satellite nanostructures with plasmonic gold nanorod dimers and upconversion nanoparticles are fabricated. Once the structure is activated, combined photothermal therapy photodynamic carried out under guidance of luminesce, T1-weighted magnetic resonance, photoacoustics, computed tomography imaging tumors in vivo, which exhibit multifunctional biological applications DNA-based self-assemblies. As a service to our authors readers, this journal provides supporting...
Although nanoparticle (NP) assemblies are at the beginning of their development, unique geometrical shapes and media-responsive optical, electronic, magnetic properties have attracted significant interest. Nanoscale assembly bridges multiple levels hierarchy materials: individual nanoparticles, discrete molecule-like or virus-like nanoscale agglomerates, microscale devices, macroscale materials. The capacity to self-assemble can greatly facilitate integration nanotechnology with other...
A self-assembled nanostar dimer based on the Hg(2+)-mediated T-T base pair of ssDNA has been developed as a SERS sensor for Hg(2+) detection. The enormous enhancement electromagnetic field by structures facilitates extraordinary intensity. LOD is 0.8 pg mL(-1) and its linear range 0.002 to 1 ng mL(-1).
Chiral nanoscale photonic systems typically follow either tetrahedral or helical geometries that require four more different constituent nanoparticles. Smaller number of particles and chiral taking advantage the self-organization capabilities nanomaterials will advance understanding plasmonic effects, facilitate development their theory stimulate practical applications chiroplasmonics. Here we show gold nanorods self-assemble into side-by-side orientated pairs "ladders" in which properties...
In this study, a hybrid nanoassembly consisting of an upconversion nanoparticle (UCNP) core and zeolitic imidazolate framework-8 (ZIF) shell encapsulated with chiral NiSx NPs (denoted as UCNP@ZIF-NiSx) were fabricated. The UCNP@ZIF-NiSx nanoassemblies showed intense circular dichroism (CD) signal at 440 530 nm, whereas the luminescence (UCL) UCNPs 540 nm quenched by UCL 660 was almost unchanged. By taking advantage chiral-optical fluorescent signals, dual mode can be used for quantitively...
Abstract Chiral plasmonic nanomaterials have attracted unprecedented attention due to their broad applications in biomedicine, negative refractive index, and chiral sensing. Here, using a wet‐chemistry process, triangular Au nanorings are fabricated with platinum (Pt) framework ( l / d ‐Pt@Au nanorings, named TNRs). The TNRs exhibit strong optical activity g ‐factor of 0.023 can be used effectively for the discrimination enantiomers selective resonance coupling between induced electric...
The chirality of nanomaterials (nanoparticles, NPs) can influence their interaction with cells and biological systems. However, how exert impact on the immune response has yet to be investigated. Here, immunological effect chiral is investigated as a therapeutic preventive option against tumors. Compared achiral nanoparticles, NPs g-factor 0.44 are shown enhance both innate acquired immunity tumor growth. It also found that activation CD8+ T natural killer (CD69+ NK cells) by stimulating...