A5100384217- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- RNA regulation and disease
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Molecular Sensors and Ion Detection
- Cancer-related gene regulation
- RNA Research and Splicing
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
- Analytical chemistry methods development
- RNA and protein synthesis mechanisms
- Health, Environment, Cognitive Aging
- Advanced Chemical Sensor Technologies
- Diet and metabolism studies
- Gene expression and cancer classification
- S100 Proteins and Annexins
- Birth, Development, and Health
- Analytical Chemistry and Sensors
- Traditional Chinese Medicine Analysis
- Biochemical and Structural Characterization
Wuhan University
1992-2025
University of Chinese Academy of Sciences
2016-2025
Dalian Institute of Chemical Physics
2021-2025
Chinese Academy of Sciences
2016-2025
Children's Hospital of Capital Institute of Pediatrics
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Guangzhou University of Chinese Medicine
2025
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
China Medical University
2020-2024
Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical and related risks. For this study, we collected serum samples from 5696 healthy people patients, including those with 12 in China completed biomonitoring 267 chemicals via gas liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected were used for exposure characterization risk analysis. The results show...
Rationale: We report here a case of using iodine-125 ( 125 I) seed implantation via endobronchial ultrasound (EBUS) in the treatment malignant central airway obstruction (MCAO) patient with lung adenocarcinoma. Patient concerns: The still experienced MCAO after conventional bronchoscopic interventional therapy. Diagnoses: was diagnosed as adenocarcinoma stage IV (T4N2M1a). Interventions: She received radioactive I seeds lesion inside right middle lobe bronchus and 12R lymph node bronchoscopy...
Abstract Societal lifestyle changes, especially increased consumption of a high-fat diet lacking dietary fibers, lead to gut microbiota dysbiosis and enhance the incidence adiposity chronic inflammatory disease. We aimed investigate metabolic effects inulin with different degrees polymerization on diet-fed C57BL/6 J mice evaluate whether health outcomes are related regulation microbiota. Short-chain long-chain inulins exert beneficial through alleviating endotoxemia inflammation....
Downy mildew of grapevine (Vitis vinifera L.), caused by the oomycete pathogen Plasmopara viticola, is one most serious concerns for grape production worldwide. It has been widely reported that pathogenesis-related 4 (PR4) protein plays important roles in plant resistance to diseases. However, little known about role PR4 defense against P. viticola. In this study, we engineered loss-of-function mutations VvPR4b gene from cultivar "Thompson Seedless" using CRISPR/Cas9 system and evaluated...
(1) Background: Aflatoxin contamination in food and grain poses serious problems both for economic development public health protection, thus leading to a focus on an effective approach control it; (2) Methods: B₁ (AFB₁) degrading bacteria were isolated using medium containing coumarin as the sole carbon source, biodegradation of AFB₁ by isolate was examined high performance liquid chromatography, chromatography mass spectrometry; (3) Results: bacterial strain exhibiting strong AFB1...
The ability to quantify cocaine in biological fluids is crucial for both the diagnosis of intoxication and overdose clinic as well investigation drug's pharmacological toxicological effects laboratory. To this end, we have performed high-stringency
Abstract In lactating mothers, the high calcium (Ca 2+ ) demand for milk production triggers significant bone loss 1 . Although oestrogen normally counteracts excessive resorption by promoting formation, this sex steroid drops precipitously during postpartum period. Here we report that brain-derived cellular communication network factor 3 (CCN3) secreted from KISS1 neurons of arcuate nucleus (ARC fills void and functions as a potent osteoanabolic to build in females. We began showing our...
Heat stress is one of the most serious threats in viticulture. shock transcription factors (HSFs) have been proven to be important transcriptional factor family plant response heat. In this study, a total 19 putative HSF genes (VHSFs) were identified from 12 × Vitis vinifera Pinot Noir PN4002 genome, and their chromosomal location, phylogenetic tree, exon-intron structure conserved motifs also analyzed. addition, these HSFs profiles 'Jingxiu' (weak heat tolerance) davidii 'Tangwei' (strong...
The effects of banana resistant starch (BRS) on obesity-related metabolic and intestinal flora were investigated in a high-fat diet-induced obesity model. After 6 weeks intervention, the glucolipid metabolism index [blood glucose (GLU), total cholesterol (TC), triacylglycerol (TG), low density lipoprotein-cholesterol (LDL-C), high (HDL-C)], hormone [leptin (LEP), insulin (INS), ghrelin, adiponectin (ADP), thyroxine (T4)], 16S rRNA sequencing analyses performed for each group to explore...
Acoustic droplet ejection (ADE)–open port interface (OPI)–mass spectrometry (MS) has recently been introduced as a versatile analytical method that combines fast and contactless acoustic sampling with sensitive accurate electrospray ionization (ESI)–MS-based analyte detection. The potential of the technology to provide label-free measurements in subsecond cycle times makes it an attractive option for high-throughput screening (HTS). Here, we report first implementation ADE-OPI-MS fully...
Aberrant production of H2O2 is involved in cancer. The levels are significantly higher tumor cells than normal cells. It important to develop fluorescent probes image basal selectively So far, a cancer cell-targeting probe has not been reported. Thus, we developed probe, BBHP, which contains benzil as H2O2-recognition site and biotin target binding motif for the selective sufficient detection BBHP enables fluorescence turn-on response H2O2. with receptors can greatly accelerate As result,...
To investigate whether gut microbiota is associated with vitamin A nutritional levels in children persistent diarrhea, a total of 59 pediatric patients diarrhea aged 1-12 months were selected from the Department Gastroenterology at Children's Hospital Chongqing Medical University, China. Subjects hospitalized and divided into VA-deficient (n = 30) VA-normal 29) groups according to their venous serum retinol levels. Fecal samples all subjects collected immediately after admission analyzed by...
Selenite is extremely biotoxic, and as a result of this, exploitation microorganisms able to reduce selenite non-toxic elemental selenium (Se0) has attracted great interest. In this study, bacterial strain exhibiting extreme tolerance (up 100 mM) was isolated from the gut adult Monochamus alternatus identified Proteus mirabilis YC801. This demonstrated efficient transformation into red nanoparticles (SeNPs) by reducing nearly 100% 1.0 5.0 mM within 42 48 h, respectively. Electron microscopy...
Abstract Omic science is rapidly growing and one of the most employed techniques to explore differential patterns in omic datasets principal component analysis (PCA). However, a method enlighten network features that mostly contribute sample separation obtained by PCA missing. An alternative build correlation networks between univariately-selected significant features, but this neglects multivariate unsupervised feature compression responsible for segregation. Biologists medical researchers...
As one of the most serious diseases in grape, downy mildew caused by Plasmopara viticola is a worldwide grape disease. Much effort has been focused on improving susceptible grapevine resistance, and wild resistant species are important for germplasm improvement commercial cultivars. Using yeast two-hybrid screen followed series immunoprecipitation experiments, we identified voltage-dependent anion channel 3 (VDAC3) protein from Vitis piasezkii 'Liuba-8' as an interacting partner VpPR10.1...
Chronic diseases have become main killers affecting the health of human, and environmental pollution is a major risk factor that cannot be ignored. It has been reported exogenous chemical residues including pesticides, herbicides, fungicides, veterinary drugs persistent organic pollutants are associated with chronic diseases. However, evidence for their relationship equivocal underlying mechanisms unclear.We aim to investigate linkages between serum 5 obesity, hyperuricemia, hypertension,...