A5083829867- Bone Metabolism and Diseases
- Oral microbiology and periodontitis research
- Bone health and treatments
- Salivary Gland Disorders and Functions
- Extracellular vesicles in disease
- HIV/AIDS oral health manifestations
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Genomics, phytochemicals, and oxidative stress
- Bone and Joint Diseases
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Digestive system and related health
- Oral Health Pathology and Treatment
- Bone health and osteoporosis research
- Breast Cancer Treatment Studies
- Neonatal and Maternal Infections
- Photodynamic Therapy Research Studies
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Brain Metastases and Treatment
Wuhan University
2016-2025
First Affiliated Hospital of Xinxiang Medical University
2023
Xi'an Jiaotong University
2023
Xinxiang Medical University
2023
Ministry of Science and Technology of the People's Republic of China
2022
Stomatology Hospital
2022
Icahn School of Medicine at Mount Sinai
2014-2019
South Central Minzu University
2018
X-Fab (Germany)
2017
Anna Needs Neuroblastoma Answers
2017
Early childhood caries (ECC) is a public healthcare concern that greatly reduces the quality of life young children. As leading factor ECC, cariogenic biofilms are composed acidogenic/aciduric pathogens and extracellular polysaccharides (EPSs), creating an acidic protected microenvironment. Antimicrobial photodynamic therapy (aPDT) noninvasive, painless, efficient therapeutic approach suitable for treating ECC. However, due to hyperfine structure biofilms, most photosensitizers (PSs) could...
Mitochondria are the powerhouse of eukaryotic cells, which regulate cell metabolism and differentiation. Recently, mitochondrial transfer between cells has been shown to direct recipient fate. However, it is unclear whether mitochondria can translocate stem this alters Here, mesenchymal (MSC) regulation examined by macrophages in bone marrow environment. It found that promote osteogenic differentiation MSCs delivering MSCs. under osteoporotic conditions, with altered phenotypes, metabolic...
Significance We have addressed the question whether osteoporosis and obesity, which often occur concurrently in postmenopausal women, can be targeted by a single agent. shown previously that reproductive hormone FSH, levels of rise after menopause, regulates both body fat bone mass. now show blocking FSH action using two purposefully designed epitope-specific antibodies protects against loss mice. This positions as lead molecules for clinical development toward future use people.
We report that oxytocin (Oxt) receptors (Oxtrs), on stimulation by the ligand Oxt, translocate into nucleus of osteoblasts, implicating this process in action Oxt osteoblast maturation. Sequential immunocytochemistry intact cells or isolated nucleoplasts stripped outer nuclear membrane showed progressive localization Oxtr; translocation was confirmed monitoring movement Oxtr-EGFP as well immunogold labeling. Nuclear Oxtr conclusively shown Western immunoblotting and MS lysate proteins. found...
Significance We show that oxytocin and vasopressin, which are released from the posterior pituitary gland to regulate lactation water balance, respectively, potent regulators of skeletal integrity. Using genetically modified mice chemical inhibitors, we provide evidence two hormones interact with each other’s receptors control precisely formation new bone.
Significance For over three decades, bisphosphonates have been used for the therapy of osteoporosis and skeletal metastasis. Here we show that this class drugs reduces viability tumor cells are driven by human epidermal growth factor receptor (HER) family tyrosine kinases. We also directly bind to inhibit HER Because inexpensive readily available worldwide, our findings may important healthcare implications offering an affordable multiuse alternative or adjunct current therapies HER-driven...
Significance Notch is a critical regulator of skeletal development, but its role in remodeling the adult skeleton unclear. Using genetically modified mice, we show that stimulates mineralization by bone-building osteoblasts. Thus, overexpression intracellular domain mice results an increase bone mass, prevents loss following ovariectomy and during aging, promotes fracture healing. therefore potential therapeutic target for conditions loss, including osteoporosis.
Significance Small molecules to target oncogenic signaling cascades in cancer have achieved success molecularly defined patient subsets. The path approval is often protracted and plagued with failures. Repositioning Food Drug Administration-approved drugs known side effects has become a major focus. Bisphosphonates are commonly prescribed therapy for osteoporosis skeletal metastases. also been associated reduced tumor burden some patients, but the mechanism unknown. Here we provide evidence...
The primitive neurohypophyseal nonapeptide oxytocin (OXT) has established functions in parturition, lactation, appetite, and social behavior. We have shown that OXT direct actions on the mammalian skeleton, stimulating bone formation by osteoblasts modulating genesis function of bone-resorbing osteoclasts. deleted receptors (OXTRs) selectively osteoclasts using Col2.3Cre Acp5Cre mice, respectively. Both male female Col2.3Cre+:Oxtrfl/fl mice recapitulate low-bone mass phenotype Oxtr+/-...
ABSTRACT Signal transducer and activator of transcription 3 (STAT3), a cytokine-responsive factor, is known to play role in immunity bone remodeling. However, whether how STAT3 impacts macrophage NLR family pyrin domain containing (NLRP3) inflammasome activation associated with inflammatory loss remains unknown. Here, signaling hyperactivated macrophages the context both non-sterile sterile osteolysis, this was highly correlated cleaved interleukin-1β (IL-1β) expression pattern. Strikingly,...
To analyse the characteristics of oral microbiomes and expected to find biomarkers about Alzheimer's disease (AD).AD patients (n = 26) cognitive intact people were examined for cognition, depression, health collected saliva gingival crevicular fluid (GCF) in morning. Full-length 16S rRNA gene was amplified sequencing performed using PacBio platform.The predominant bacterium salivary microbiome periodontal from AD Streptococcus oralis Porphyromonas gingivalis, respectively. With respect β...
Background: Sulforaphane (SFN), an isothiocyanate naturally occurring in cruciferous vegetables, is a potent indirect antioxidant and promising agent for the control of metabolic disorder disease. The glucose intolerance adipogenesis induced by diet rats was inhibited SFN. Strategies aimed at induction brown adipose tissue (BAT) could be potentially useful way to against obesity. However, vivo protective effect SFN obesity browning white adipocyte has not been reported. Our present study...
Periodontitis is a worldwide oral disease induced by the interaction of subgingival bacteria and host response characterized local inflammation, bone resorption, tooth loss. Ginsenoside Rd (Rd) biologically active component derived from Panax ginseng has been demonstrated to exert antibacterial anti-inflammatory activities. This study aims investigate inhibitory efficiency towards Porphyromonas gingivalis ( P. ), periodontal inflammatory response, osteoclastogenesis in vitro further validate...
Conventional treatments for chronic periodontitis are less effective in controlling inflammation and often relapse. Therefore, it is necessary to explore an immunomodulatory medication as adjuvant. Ginsenoside Rb3 (Rb3), one of the most abundant active components ginseng, has been found possess anti-inflammatory properties. Here, we detected effect on Porphyromonas gingivalis LPS-stimulated human periodontal ligament cells experimental rats first time. We that expression pro-inflammatory...
Biomineralization is a chemical reaction that occurs in organisms which collagen initiates and guides the growth crystallization of matched apatite minerals. However, there little known about demand pattern for calcium salts needed by biomineralization. In this study, natural bone biomineralization analyzed, novel interplay between concentration production observed. Any quantitative change one entities causes corresponding other. Translocation-associated membrane protein 2 (TRAM2) identified...
Abstract Background Breast cancer metastasis to the bone can be exacerbated by osteoporosis, is associated with poor long-term survival, and has limited therapeutic options. Sclerostin (SOST) an endogenous inhibitor of formation, attractive target for treatment osteoporosis. However, it unclear whether SOST used as a metastases breast cancer, small molecule compounds that in cells inhibit metastasis. Methods expression 442 tissues was characterized immunohistochemistry statistically analyzed...
Previous studies have demonstrated that sulforaphane (SFN) is a promising agent against osteoclastic bone destruction. However, the mechanism underlying its anti-osteoclastogenic activity still unclear. Herein, for first time, we explored potential role of autophagy in SFN-mediated anti-osteoclastogenesis vitro and vivo. We established an osteoclastogenesis model using receptor activator nuclear factor kappa-β ligand (RANKL)-induced RAW264.7 cells marrow macrophages (BMMs)....