A5090623269- Ovarian function and disorders
- Adipose Tissue and Metabolism
- Nutrition, Genetics, and Disease
- Regulation of Appetite and Obesity
- Estrogen and related hormone effects
- Human Health and Disease
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Biology and Fertility
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Hormonal and reproductive studies
- Vitamin D Research Studies
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Glutathione Transferases and Polymorphisms
- Agriculture and Biological Studies
- Social and Behavioral Studies
- Neuroscience of respiration and sleep
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Computational Drug Discovery Methods
- Folate and B Vitamins Research
- Nuclear Receptors and Signaling
- Sexual function and dysfunction studies
- Reproductive tract infections research
Scientific Center of Family Health Problems and Human Reproduction
2014-2024
Icahn School of Medicine at Mount Sinai
2019-2023
The Mount
2022
John Wiley & Sons (United States)
2020
Ministry of Health of the Russian Federation
2019
Significance We report the development and characterization of a first-in-class humanized antibody to follicle-stimulating hormone (FSH). have shown previously that blocking FSH action on its receptor increases bone mass, reduces body fat, enhances energy expenditure. Furthermore, has been reported increase serum cholesterol. Therefore, an anti-FSH agent potential preventing treating obesity, osteoporosis, hypercholesterolemia, diseases affect millions women men worldwide. Our study provides...
The primitive neurohypophyseal nonapeptide oxytocin (OXT) has established functions in parturition, lactation, appetite, and social behavior. We have shown that OXT direct actions on the mammalian skeleton, stimulating bone formation by osteoblasts modulating genesis function of bone-resorbing osteoclasts. deleted receptors (OXTRs) selectively osteoclasts using Col2.3Cre Acp5Cre mice, respectively. Both male female Col2.3Cre+:Oxtrfl/fl mice recapitulate low-bone mass phenotype Oxtr+/-...
Pharmacological and genetic studies over the past decade have established follicle-stimulating hormone (FSH) as an actionable target for diseases affecting millions, namely osteoporosis, obesity, Alzheimer's disease. Blocking FSH action prevents bone loss, fat gain, neurodegeneration in mice. We recently developed a first-in-class, humanized, epitope-specific FSH-blocking antibody, MS-Hu6, with K
Abstract Context Previous studies have shown that the prevalence of polycystic ovary syndrome (PCOS) may vary according to race/ethnicity, although a few assessed women different ethnicities who live in similar geographic and socioeconomic conditions. Objective To determine PCOS an unselected multiethnic population premenopausal women. Design A multicenter prospective cross-sectional study. Settings The main regional employers Irkutsk Region Buryat Republic, Russia. Participants During...
Significance Tadalafil and vardenafil are among the most widely used drugs for erectile dysfunction, which affects nearly 19% of men over 20 y age. Older also suffer from age-related bone loss resulting in crippling fractures. We show that mice, both agents act on cells, formation new reduced removal old bone. Because this net gain mass, we posit tadalafil could be cotreating dysfunction osteoporosis advancing age, as well treating postmenopausal women. recommend future clinical studies to...
Abnormalities in gut microbiota diversity are considered important mechanisms metabolic disorders polycystic ovarian syndrome (PCOS). However, the data on association of these with PCOS phenotype remain controversial. The objectives this study were to estimate alpha healthy women and patients depending phenotype. participants (184 premenopausal women: 63 PCOS, 121 without PCOS) recruited during annual employment assessment Irkutsk Region Buryat Republic (Russia) 2016-2019. For diagnosis, we...
Keywords: pelvic ultrasound, follicle number per ovary, FNPO, ovarian volume, PCOM, upper normal limits, referral population
Polycystic ovary syndrome (PCOS) is a highly prevalent disorder in women, and its diagnosis rests on three principal features: ovulatory/menstrual dysfunction, clinical and/or biochemical hyperandrogenism, polycystic ovarian morphology (PCOM). Currently, data age- ethnicity-dependent features of PCOM remain insufficient. We aimed to estimate ethnicity- age-dependent differences volume (OV) follicle number per (FNPO) healthy, medically unbiased population Caucasian Asian premenopausal who...
Leydig cell tumors (LCTs) refer to of the stroma genital strand, which are found mainly in postmenopausal women. The diagnosis LCTs women is associated with specific difficulties and based on identification hyperandrogenism clinical manifestations virilization, has an erased picture require differential other causes hyperandrogenism. We present case a 55-year-old Russian patient right ovary, significantly increased levels androgens, rapidly progressive signs underwent laparoscopic bilateral...
Androgen assessment is a key element for diagnosing polycystic ovary syndrome (PCOS), and defining "normal" level of circulating androgens critical epidemiological studies. We determined the upper normal limits (UNLs) in population-based group premenopausal "healthy control" women, overall by ethnicity (Caucasian Asian), cross-sectional Eastern Siberia PCOS Epidemiology Phenotype (ESPEP) Study (ClinicalTrials.gov ID: NCT05194384) conducted 2016-2019. Overall, we identified consisting 143...
Testosterone assessment is essential for detecting biochemical hyperandrogenism, one of the important diagnostic criteria polycystic ovary syndrome (PCOS) both in clinical practice and epidemiological studies. Currently, tandem liquid chromatography-mass spectrometry (LC-MS/MS) most preferred technique to measure testosterone level women. Its validation reproducibility androgen tests results studies prevalence PCOS. The aim study. To develop validate a method determining total blood serum...
Background. Currently more than 119 obesity-related polymorphisms is known to participate in adult obesity. One of them LEPR Q223R. Many researches shown association this polymorphism with However, the role Q223R adolescent overweight and obesity matter dispute. Aim: determine gene some biochemical hormonal measurements blood female adolescents normal weight Materials methods. A total 103 (14-17 years age) was examined. All girls were divided into 2 groups: 43 (SDS BM 10.311 ± 0.585), 65 BMI...
To identify the association between Ile105Val, Ala114Val polymorphisms of gene GSTP1 (glutathione transferase pi1) and infertility in Russian men.A total 160 infertile men reproductive age (mean 30.2+/-3.6 years) were included study group, while control group there 104 age-matched healthy fertile male 31.3+/-5.4 years). Molecular genetic studies performed using real-time polymerase chain reaction. Genomic DNA was extracted from peripheral blood.A frequency genotypes (p=0.024; df=2; p=0.024)...
Background. Chronic endometritis (CE) is an inflammatory hysteropathy causing miscarriage and infertility. High invasiveness of the main method CE diagnosis vague clinical picture necessitate need for development less invasive approaches to establish presence this disease.The aim study. To a significant association concentration pro- anti-inflammatory interleukins in blood serum with chronic premenopausal women without concomitant endocrine diseases.Materials methods. This re-analysis data...
Background. Genotypes of the cytochrome p450 isoform (CYP2C9 and CYP4F2) determine warfarin dose requirements. Frequencies risk alleles genotypes CYP2C9 CYP4F2 gene vary in different races ethnic groups. Aim. This study analyzed frequencies *2, *3 1347 C>T allele Caucasians Eastern Siberia, compare with other populations. Materials methods. Participants were 147 patients (Caucasians): 67 (45.58 %) man 80 (54.42 women), taking for prevention thrombosis a mean age 64.74 ± 14.29 years. There...
Objective. To evaluate serum concentrations of leptin and adiponectin their association with chronic endometritis (CE) in reproductive-aged women. Patients methods. The study included 198 women who were recruited during general health checks. All patients underwent anthropometric (body mass index (BMI), body fat percentage) instrumental (pelvic ultrasound, endometrial pipelle biopsy CD138 immunohistochemistry) examinations, levels determined. Non-parametric methods logistic regression used...
Climatic and geographical features always influenced on adaptation to the environment as well development level of economy culture. The formation certain food behavior in population determined fixation specific gene alleles mutation. They were responsible for digestion a typical population. At moment there is information about such genetic metabolism proteins, carbohydrates fats many races nations. But few studies are causes prevalence differences polymorphisms folate cycle world's...
BACKGROUND: The melanocortin 4 receptor gene (MC4R) codes the expressed in hypothalamus and involved regulation of body mass height. Data on association polymorphism MC4R rs17782313 with anthropometric parameters are contradictory. AIMS: to study influence carrier adolescents different ethnic groups: caucasians mongoloids living Siberia. MATERIALS AND METHODS: included 179 caucasian (by example russians, average age is 15.07 1.25 years) 182 mongoloid buryats, 14.71 1.28 years), 89 92 were...
The problem of overweight and obesity is one the most urgent health issues in world. 13% girls 21% boys aged 11 suffer from Russian Federation.The main causes pubertal are endocrine pathology, lifestyle genetic disorders including mutation polymorphisms different metabolic pathways. Leptin produced adipose tissue participates reproduction regula-tion, glucose homeostasis, bone formation, etc. These effects provided by leptin receptors coding LEPR gene. Q223R (rs1137101) polymorphism...