A5071006611- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Bone health and treatments
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Bone health and osteoporosis research
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Eicosanoids and Hypertension Pharmacology
- Muscle Physiology and Disorders
- Spaceflight effects on biology
- Reproductive System and Pregnancy
- Cell Adhesion Molecules Research
- Hypothalamic control of reproductive hormones
- Stress Responses and Cortisol
- Folate and B Vitamins Research
- Growth Hormone and Insulin-like Growth Factors
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Fatty Acid Research and Health
- Bone and Dental Protein Studies
- Bone Tissue Engineering Materials
- Muscle metabolism and nutrition
- Adrenal Hormones and Disorders
- Radiopharmaceutical Chemistry and Applications
University of Bari Aldo Moro
2016-2025
John Wiley & Sons (United States)
2024
Hudson Institute
2024
Zero to Three
2020
Icahn School of Medicine at Mount Sinai
2006-2014
James J. Peters VA Medical Center
2011
Washington University in St. Louis
2003-2007
University of Foggia
2004
Significance Although exercise is a well known and potent stimulus for new bone formation, weightlessness or muscle loss characteristically cause loss, it has remained unclear how talks to bone, despite their close proximity. Here, we show that molecule irisin derived from skeletal in response profound effects enhancing mass improving the geometry strength specifically of cortical key function which resist bending torsion. Trabecular reservoir bodily calcium, remarkably spared. Irisin may...
Abstract We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays central role in the control of bone mass. Here we report treatment with recombinant Irisin prevented loss hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery mass were injected due to period 4 weeks (curative protocol). MicroCT analysis femurs r-Irisin preserved both cortical trabecular mineral density, dramatic decrease volume...
It has been recently demonstrated that exercise activity increases the expression of myokine Irisin in skeletal muscle, which is able to drive transition white brown adipocytes, likely following a phenomenon transdifferentiation. This new evidence supports idea muscle can be considered an endocrine organ, given its ability target adipose tissue by promoting energy expenditure. In accordance with these findings, we hypothesized directly involved bone metabolism, demonstrating increase...
We report that oxytocin (OT), a primitive neurohypophyseal hormone, hitherto thought solely to modulate lactation and social bonding, is direct regulator of bone mass. Deletion OT or the receptor (Oxtr) in male female mice causes osteoporosis resulting from reduced formation. Consistent with low formation, stimulates differentiation osteoblasts mineralizing phenotype by causing up-regulation BMP-2, which turn controls Schnurri-2 3, Osterix, ATF-4 expression. In contrast, has dual effects on...
Significance In this study, we show that a primitive brain hormone, arginine vasopressin (AVP), which has hitherto been implicated in regulating water balance mammals, function skeletal homeostasis. Using genetically modified mice are lacking one of the AVP receptors as well pharmacologic inhibitors, negatively regulates osteoblasts (cells form new bone) and stimulates osteoclasts remove old bone). Our findings explain bone loss is known to accompany low blood sodium levels patients when high.
ABSTRACT Previous results showed that intermittently administered irisin improves bone mass in normal mice and prevents the development of disuse-induced osteoporosis muscular atrophy hindlimb-suspended mice, a murine model able to mimic absence mechanical loading. A recent study increases survival osteocytes acting through integrin αV/β5 receptors. To better understand action on these cells, we investigated downstream signaling cascades osteocyte-like cells (MLO-Y4) treated with recombinant...
Abstract The world population is increasingly aging, deeply affecting our society by challenging healthcare systems and presenting an economic burden, thus turning the spotlight on aging-related diseases: exempli gratia, osteoporosis, a silent disease until you suddenly break bone. increase in bone fracture risk with age generally associated loss of mass alteration skeletal architecture. However, such changes cannot fully explain increased fragility age. To successfully tackle age-related...
Increased plasma homocysteine (HCY) may be an independent risk factor for osteoporotic fractures and therefore also adversely affect bone metabolism. We analyzed the effect of HCY on human osteoclast (OC) activity.We cultured peripheral blood mononuclear cells from 17 healthy male donors [median (SD) age, 30 (5) years] 20 days with 25 microg/L macrophage-colony-stimulating (days 0-11), receptor-activator nuclear factor-kappaB ligand 6-20), 4 different concentrations (0, 10, 50, 100...
During space flight, severe losses of bone mass are observed. Both formation and resorption probably involved, but their relative importance remains unclear. The purpose this research is to understand the role osteoclasts precursors in microgravity-induced loss. Three experiments on isolated (OCs) precursors, OSTEO, OCLAST, PITS, were launched FOTON-M3 mission. OSTEO experiment was conducted for 10 d microgravity within bioreactors with a perfusion system, where differentiation cultured...
Childhood type 1 diabetes mellitus (T1DM) is associated with decreased bone mass. Sclerostin and dickkopf-1 (DKK-1) are Wnt inhibitors that regulate formation.To evaluate sclerostin DKK-1 levels in T1DM children to analyze the influence of glycemic control on health.Cross-sectional study conducted at a clinical research center.One hundred six subjects (12.2 ± 4 years), 66 multiple daily injections (MDIs) 40 continuous subcutaneous infusion insulin (CSII), 80 controls.The average transmission...
Several studies have reported the beneficial effects of mesenchymal stem cells (MSCs) in tissue repair and regeneration. New sources adult organisms are continuously emerging; dental tissues been identified as a source postnatal MSCs. Dental bud is immature precursor tooth, easy to access we show this study that it can yield high number with ≥95% expression stemness makers osteogenic capacity. Thus, these be defined Bud Stem Cells (DBSCs) representing promising for bone regeneration...
We report that oxytocin (Oxt) receptors (Oxtrs), on stimulation by the ligand Oxt, translocate into nucleus of osteoblasts, implicating this process in action Oxt osteoblast maturation. Sequential immunocytochemistry intact cells or isolated nucleoplasts stripped outer nuclear membrane showed progressive localization Oxtr; translocation was confirmed monitoring movement Oxtr-EGFP as well immunogold labeling. Nuclear Oxtr conclusively shown Western immunoblotting and MS lysate proteins. found...
ABSTRACT Irisin is a myokine produced by skeletal muscle during exercise in both mice and humans. We previously showed that irisin treatment ameliorates immobility-induced osteoporosis muscular atrophy mice. Data humans positive association between bone mineral density (BMD) athletes population of healthy children. However, the role this regarding state same remained to be determined. For purpose, 62 patients (age 68.71 ± 12.31 years) undergoing total hip or knee replacement were recruited....
Bone fractures are a widespread clinical event due to accidental falls and trauma or bone fragility; they also occur in association with various diseases common aging. In the search for new therapeutic strategies, crucial link between irisin has recently emerged. To explore this issue, we subjected 8-week-old C57BL/6 male mice tibial fracture, then treated them intra-peritoneal injection of r-Irisin (100 µg/kg/weekly) vehicle as control. At day 10 post histological analysis showed...
We have shown that the anterior pituitary hormone, thyroid-stimulating hormone (TSH), can bypass thyroid to exert a direct protective effect on skeleton. Thus, we suggested low TSH level may contribute bone loss of hyperthyroidism has been attributed traditionally high levels. Earlier mouse genetic, cell-based, and clinical studies together established inhibits osteoclastic resorption. However, influence osteoblast remained unclear. Here, used model system developed from murine ES cells,...