A5089822472- Bone health and treatments
- Bone health and osteoporosis research
- Growth Hormone and Insulin-like Growth Factors
- Bone Metabolism and Diseases
- Estrogen and related hormone effects
- Pituitary Gland Disorders and Treatments
- Vitamin D Research Studies
- Protein purification and stability
- Monoclonal and Polyclonal Antibodies Research
- Stress Responses and Cortisol
- Artificial Intelligence in Healthcare and Education
- Radiopharmaceutical Chemistry and Applications
- Thyroid Disorders and Treatments
- Bone and Joint Diseases
- Sexual Differentiation and Disorders
- Hemoglobinopathies and Related Disorders
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Iron Metabolism and Disorders
- Parathyroid Disorders and Treatments
- Connective tissue disorders research
- Lung Cancer Treatments and Mutations
- Advanced Algebra and Geometry
- Myasthenia Gravis and Thymoma
- Bone and Dental Protein Studies
Icahn School of Medicine at Mount Sinai
2014-2024
Gachon University
2024
Soon Chun Hyang University Cheonan Hospital
2024
Gangneung–Wonju National University
2024
Ewha Womans University
2024
Mount Sinai Health System
2024
The Mount
2021-2023
Korea Food Research Institute
2023
Jeonbuk National University
2023
University of California, San Francisco
2021
Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition that arises from mutations in CYP21A2 gene, which encodes for the steroidogenic enzyme 21-hydroxylase. To prevent genital ambiguity affected female fetuses, prenatal treatment with dexamethasone must begin on or before gestational week 9. Currently used chorionic villus sampling and amniocentesis provide genetic results at approximately 14 weeks of gestation earliest. This means mothers who want to undergo will be...
The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate loss bone integrity disease. Recent breakthroughs have arisen mainly from identifying disease-causing mutations modeling human disease rodents, essence, highlighting integrative nature physiology. It become increasingly clear cells, osteoblasts, osteoclasts, osteocytes, communicate regulate fate each other through RANK/RANKL/OPG, liver X receptors (LXRs), EphirinB2-EphB4...
Significance We have addressed the question whether osteoporosis and obesity, which often occur concurrently in postmenopausal women, can be targeted by a single agent. shown previously that reproductive hormone FSH, levels of rise after menopause, regulates both body fat bone mass. now show blocking FSH action using two purposefully designed epitope-specific antibodies protects against loss mice. This positions as lead molecules for clinical development toward future use people.
Significance Gaucher disease is a rare genetic disorder that has crippling health consequences. Mutations in the GBA1 gene are known to disrupt enzyme glucocerebrosidase-1, but it not known, at atom-level detail, as how function lost. This study uses multiscale simulations and deep learning define precisely mechanism underlying disruption of glucocerebrosidase-1 and, particular, its interaction with facilitator protein, saposin C.
Significance For over three decades, bisphosphonates have been used for the therapy of osteoporosis and skeletal metastasis. Here we show that this class drugs reduces viability tumor cells are driven by human epidermal growth factor receptor (HER) family tyrosine kinases. We also directly bind to inhibit HER Because inexpensive readily available worldwide, our findings may important healthcare implications offering an affordable multiuse alternative or adjunct current therapies HER-driven...
Significance Apparent mineralocorticoid excess, a rare autosomal recessive disorder characterized by low renin hypertension, may display severe or mild phenotype in patients. The variability clinical presentation stems from different extents of impairment the 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) enzyme arising distinct mutations encoding gene. computational model HSD11B2 protein that we constructed here will be useful predicting disease severity for newly reported missense this
Significance Small molecules to target oncogenic signaling cascades in cancer have achieved success molecularly defined patient subsets. The path approval is often protracted and plagued with failures. Repositioning Food Drug Administration-approved drugs known side effects has become a major focus. Bisphosphonates are commonly prescribed therapy for osteoporosis skeletal metastases. also been associated reduced tumor burden some patients, but the mechanism unknown. Here we provide evidence...
Abstract The Study of Women’s Health Across the Nation has taught us that impending ovarian failure during late perimenopause is associated with a sharp rise in serum FSH, which coincides most rapid rate bone loss and onset visceral adiposity. At this time woman’s life, estrogen levels are largely unaltered, so hypothesis hypoestrogenemia sole cause obesity does not offer full explanation. An alternative explanation, arising from animal models human data, both physiologic aberrations,...
Significance We report the development and characterization of a first-in-class humanized antibody to follicle-stimulating hormone (FSH). have shown previously that blocking FSH action on its receptor increases bone mass, reduces body fat, enhances energy expenditure. Furthermore, has been reported increase serum cholesterol. Therefore, an anti-FSH agent potential preventing treating obesity, osteoporosis, hypercholesterolemia, diseases affect millions women men worldwide. Our study provides...
The primitive neurohypophyseal nonapeptide oxytocin (OXT) has established functions in parturition, lactation, appetite, and social behavior. We have shown that OXT direct actions on the mammalian skeleton, stimulating bone formation by osteoblasts modulating genesis function of bone-resorbing osteoclasts. deleted receptors (OXTRs) selectively osteoclasts using Col2.3Cre Acp5Cre mice, respectively. Both male female Col2.3Cre+:Oxtrfl/fl mice recapitulate low-bone mass phenotype Oxtr+/-...
Pharmacological and genetic studies over the past decade have established follicle-stimulating hormone (FSH) as an actionable target for diseases affecting millions, namely osteoporosis, obesity, Alzheimer's disease. Blocking FSH action prevents bone loss, fat gain, neurodegeneration in mice. We recently developed a first-in-class, humanized, epitope-specific FSH-blocking antibody, MS-Hu6, with K
We consider the design of decision rules in an environment with two alternatives, independent private values and no monetary transfers. The utilitarian rule subject to incentive compatibility constraints is a weighted majority rule, where agents' weights correspond expected gains given that their favorite alternative chosen. It shown interim efficient if only it we characterize those are ex ante efficient. also discuss efficiency class anonymous mechanisms stability rules.
There is increasing evidence that anterior pituitary hormones, traditionally thought to have unitary functions in regulating single endocrine targets, act on multiple somatic tissues, such as bone, fat, and liver. also emerging for hormone action brain receptors mediating central neural peripheral functions. Here, we created the most comprehensive neuroanatomical atlas expression of TSHR, LHCGR, FSHR. We used RNAscope, a technology allows detection mRNA at single-transcript level, together...
Highly concentrated antibody formulations are oftentimes required for subcutaneous, self-administered biologics. Here, we report the development of a unique formulation our first-in-class FSH-blocking humanized antibody, MS-Hu6, which propose to move clinic osteoporosis, obesity, and Alzheimer's disease. The studies were carried out using Good Laboratory Practice (GLP) platform, compliant with Code Federal Regulations (Title 21, Part 58). We first used protein thermal shift, size exclusion...
Significance Fibrous sheath interacting protein 1 (FSIP1) has been identified as a poor prognostic indicator of breast cancer. Here, we report that FSIP1 positively regulates the proliferation and invasion triple-negative cancer (TNBC) cells, its silencing promotes drug resistance by inducing autophagy, reducing mitochondrial biogenesis, enhancing AMP-activated kinase activation. Collectively, our findings may aid in design therapies for advanced TNBC.
Background: Erythroblast erythroferrone (ERFE) secretion inhibits hepcidin expression by sequestering several bone morphogenetic protein (BMP) family members to increase iron availability for erythropoiesis. Methods: To address whether ERFE functions also in and the mechanism of action involves BMPs, we utilize Erfe -/- mouse model as well β–thalassemic ( Hbb th3/+ ) mice with systemic loss expression. In additional, employ comprehensive skeletal phenotyping analyses functional assays vitro...