A5046736556- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Pancreatic function and diabetes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- Metabolomics and Mass Spectrometry Studies
- Growth Hormone and Insulin-like Growth Factors
- Medical Imaging Techniques and Applications
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Nuclear Structure and Function
- Metabolism and Genetic Disorders
- Lanthanide and Transition Metal Complexes
- Asthma and respiratory diseases
- Cannabis and Cannabinoid Research
- Tracheal and airway disorders
- Calcium signaling and nucleotide metabolism
- Lipid metabolism and disorders
- Hormonal Regulation and Hypertension
Medical University of Vienna
2016-2025
Icahn School of Medicine at Mount Sinai
2008-2023
University of Vienna
2023
Guided Therapeutics (United States)
2023
Kantonsspital Graubünden
2023
University of Zurich
2000-2022
Plansee (Austria)
2022
University Hospital of Zurich
1997-2022
GastroZentrum Hirslanden Zürich
2012-2019
Klinik Hirslanden
2017
We investigated psychophysiological responses to fear and anger inductions during real‐life imagination. Female participants ( N = 158) were assigned a fear‐treatment, fear‐control, anger‐treatment, or anger‐control group. Context (real‐life, imagination) was varied in two sessions of fixed order. Eleven self‐report 29 somatovisceral variables registered. Results showed that (a) except imagination, control groups emotionless; (b) groups, contexts prompted diverging responses, but similar...
Cachexia, defined as an involuntary weight loss ≥5%, is a serious and dose-limiting side effect of chemotherapy that decreases survival in cancer patients. Alterations lipid metabolism are thought to cause the lipodystrophy commonly associated with cachexia. Ghrelin has been proposed ameliorate alterations due its orexigenic anabolic properties. However, mechanisms action through which ghrelin could potentially chemotherapy-associated cachexia have not elucidated. The objectives this study...
Abstract Hepatic steatosis develops when lipid influx and production exceed the liver’s ability to utilize/export triglycerides. Obesity promotes is characterized by leptin resistance. A role of in hepatic handling highlighted observation that recombinant reverses hypoleptinemic patients with lipodystrophy an unknown mechanism. Since mainly functions via CNS signaling, we here examine rats whether regulates flux brain a series stereotaxic infusion experiments. We demonstrate protects from...
Abstract Background and purpose Two novel enzyme replacement therapies (ERTs), studied in phase 3 trials late‐onset Pompe patients, reached marketing authorization by the European Medicines Agency 2022 2023. The Consortium (EPOC) updates extends scope of 2017 recommendations for starting, switching stopping ERT. Methods consists 25 neuromuscular metabolic experts from eight countries. This update was performed after an in‐person meeting, three rounds discussion voting to provide a consensus...
Tangier disease (TD) is a rare, autosomal recessive genetic disorder associated with deficiency in cellular cholesterol export leading to accumulation peripheral tissues. With approximately 150 described cases, the significantly understudied, and clinical presentation appears be heterogenous. To investigate phenotype lipid metabolism TD. Multicenter cohort study. Four patients Nuclear magnetic resonance (NMR)-based lipidomic metabolomic analyses were performed TD healthy controls. While...
Inspiratory muscle training may have beneficial effects in certain patients with chronic obstructive pulmonary disease (COPD). Because of the lack a home device, normocapnic hyperpnea has rarely been used as mode for COPD, and is generally considered unsuitable to large-scale application. To study training, we randomized 30 COPD ventilatory limitation respiratory (RMT; n = 15) new portable device or breathing exercises an incentive spirometer (controls; 15). Both groups trained twice daily...
Rats given alcohol to simulate binge drinking exhibit the first signs of diabetes, a result altered insulin action in brain.
Hepatic steatosis is common in obesity and insulin resistance results from a net retention of lipids the liver. A key mechanism to prevent increase secretion triglycerides (TG) packaged as VLDLs. Insulin controls nutrient partitioning via signaling through its cognate receptor peripheral target organs such liver, muscle, adipose tissue central nervous system (CNS) orchestrate organ cross talk. While hepatic known suppress VLDL production it unknown whether brain independently regulates...
Insulin controls fatty acid (FA) release from white adipose tissue (WAT) through direct effects on adipocytes and indirectly hypothalamic signaling by reducing sympathetic nervous system outflow to WAT. Uncontrolled FA WAT promotes lipotoxicity, which is characterized inflammation insulin resistance that leads worsens type 2 diabetes. Here we tested whether early diet-induced impairs the ability of regulate lipolysis thus contributes dysfunction. To this end fed male Sprague-Dawley rats a...
Glucocorticoids (GCs) are important regulators of systemic energy metabolism, and aberrant GC action is linked to metabolic dysfunctions. Yet, the extent which normal pathophysiological metabolism depend on receptor (GR) in adipocytes remains unclear. Here, we demonstrate that adipocyte GR deficiency mice significantly impacts different energetic states. Plasma metabolomics biochemical analyses revealed a marked global effect metabolite abundance and, thus, substrate partitioning fed fasted...
Insulin infused into the central nervous system of rats suppresses lipolysis in white adipose tissue, indicating a role brain insulin regulating systemic lipid metabolism.We investigated whether delivery healthy humans.Placebo-controlled, balanced within-subject comparisons were performed both main and an independent corroborative experiment. SETTING/PARTICIPANTS/INTERVENTION: Two groups volunteers examined at German University Clinics Lübeck Tübingen, respectively, with molecular analyses...
Significance Small molecules to target oncogenic signaling cascades in cancer have achieved success molecularly defined patient subsets. The path approval is often protracted and plagued with failures. Repositioning Food Drug Administration-approved drugs known side effects has become a major focus. Bisphosphonates are commonly prescribed therapy for osteoporosis skeletal metastases. also been associated reduced tumor burden some patients, but the mechanism unknown. Here we provide evidence...
Abstract Deuterium metabolic imaging (DMI) is an emerging magnetic resonance technique, for non‐invasive mapping of human brain glucose metabolism following oral or intravenous administration deuterium‐labeled glucose. Regional differences in can be observed various pathologies, such as Alzheimer's disease, cancer, epilepsy schizophrenia, but the achievable spatial resolution conventional phase‐encoded DMI methods limited due to prolonged acquisition times rendering submilliliter isotropic...
Study objectiveTo compare the effect of high-frequency oral airway oscillation, chest wall and conventional physical therapy (CPT) on weight expectorated sputum, pulmonary function, oxygen saturation in outpatients with stable cystic fibrosis (CF).DesignProspective randomized trial.SettingPediatric division a tertiary care center.PatientsFourteen CF recruited from center.InterventionsTwo modes oscillation (1: frequency 8 Hz; inspiratory to expiratory [LE] ratio 9:1; 2: 14 I:E 8:1), two 3...
OBJECTIVE The endocannabinoid (EC) system has been implicated as an important regulator of energy homeostasis. In obesity and type 2 diabetes, EC tone is elevated in peripheral tissues including liver, muscle, fat, also centrally, particularly the hypothalamus. Cannabinoid receptor 1 (CB1) blockade with centrally peripherally acting rimonabant induces weight loss improves glucose homeostasis while causing psychiatric adverse effects. relative contributions versus central signaling on remain...