A5055859715- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Diabetes Management and Research
- Thyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Growth Hormone and Insulin-like Growth Factors
- Corporate Governance and Management
- Pancreatic function and diabetes
- Adrenal Hormones and Disorders
- Pituitary Gland Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thyroid Cancer Diagnosis and Treatment
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Body Contouring and Surgery
- Cardiovascular Disease and Adiposity
- Vitamin D Research Studies
- Renal Transplantation Outcomes and Treatments
Medical University of Vienna
2015-2024
FHNW University of Applied Sciences and Arts
2023
Universitätszahnklinik Wien
2020
Schilddrüsenpraxis Josefstadt
2018
Google (United States)
2018
Bridgewater College
2014
Karl Landsteiner Society
2012
Technical University of Darmstadt
2005
University of Vienna
1997-2003
Freie Universität Berlin
2000
A consensus meeting was held in Vienna on September 8–9, 2013, to discuss diagnostic and therapeutic challenges surrounding development of diabetes mellitus after transplantation. The International Expert Panel comprised 24 transplant nephrologists, surgeons, diabetologists clinical scientists, which met with the aim review previous guidelines light emerging data research. Recommendations from discussions are provided this article. Although kidney-centric, reflecting expertise present, these...
S6K1 has emerged as a critical signaling component in the development of insulin resistance through phosphorylation and inhibition IRS-1 function. This effect can be triggered directly by nutrients such amino acids or homeostatic negative-feedback loop. However, role mediating physiological setting nutrient overload is unresolved. Here we show that phosphorylates Ser-1101 vitro C-terminal domain protein mutation this site largely blocks ability to suppress tyrosine Akt phosphorylation....
Plasma concentrations of amino acids are frequently elevated in insulin-resistant states, and a protein-enriched diet can impair glucose metabolism. This study examined effects short-term plasma acid (AA) elevation on whole-body disposal cellular insulin action skeletal muscle. Seven healthy men were studied for 5.5 h during euglycemic (5.5 mmol/l), hyperinsulinemic (430 pmol/l), fasting glucagon (65 ng/l), growth hormone (0.4 μg/l) somatostatin clamp tests the presence low (∼1.6 mmol/l)...
To examine the molecular mechanisms by which plasma amino acid elevation impairs insulin action, we studied seven healthy men twice in random order during infusion of an mixture or saline (total ∼6 vs. ∼2 mmol/l). Somatostatin-insulin-glucose clamps created conditions low peripheral hyperinsulinemia (∼100 pmol/l, 0–180 min) and prandial-like (∼430 180–360 min). At hyperinsulinemia, endogenous glucose production (EGP) did not change but decreased ∼70% (EGP150–180 min 11 ± 1 3 μmol · kg−1...
No effective interventions to reduce risk for new-onset diabetes after transplantation (NODAT), a condition associated with postoperative hyperglycemia and reduced patient graft survival, have been established. In this 1-year, proof-of-concept clinical trial, we randomly assigned 50 renal transplant recipients immediate-postoperative isophane insulin evening blood glucose ≥140 mg/dl (treatment group) or short-acting and/or oral antidiabetic agents ≥180-250 (standard-of-care control group)....
This European expert consensus statement provides recommendations for the diagnosis and management of primary hyperparathyroidism (PHPT), chronic hypoparathyroidism in adults (HypoPT), parathyroid disorders relation to pregnancy lactation. Specified areas interest unmet needs identified by experts at second ESE Educational Program Parathyroid Disorders (PARAT) 2019, were discussed during two virtual workshops 2021, subsequently developed working groups with specified areas. PHPT is a common...
Finerenone reduced the risk of kidney and cardiovascular events in people with chronic disease (CKD) type 2 diabetes FIDELIO-DKD FIGARO-DKD phase 3 studies. Effects finerenone on outcomes patients taking sodium-glucose cotransporter inhibitors (SGLT2is) were evaluated a prespecified pooled analysis these studies.Patients urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m2 randomly assigned or placebo; SGLT2is permitted at...
ABSTRACT Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity diagnosis, risk stratification management. However, the last decade has seen significant advancements our knowledge complemented by rapidly changing treatment algorithms for management of general population. In view these developments, ensure reduced...
The nutrient-sensitive kinase mammalian target of rapamycin (mTOR) and its downstream S6 (S6K) are involved in amino acid-induced insulin resistance. Whether the mTOR/S6K pathway directly modulates glucose metabolism humans is unknown. We studied 11 healthy men (29 years old, BMI 23 kg/m(2)) twice random order after oral administration 6 mg rapamycin, a specific mTOR inhibitor, or placebo. An acid mixture was infused to activate mTOR, somatostatin-insulin-glucose clamps created conditions...
BACKGROUND Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine linked to obesity comorbidities such as cardiovascular disease, inflammation, and cancer. GDF-15 also has adipokine properties recently emerged prognostic biomarker for events. METHODS We evaluated the relationship of plasma concentrations with parameters obesity, glucose lipid metabolism in cohort 118 morbidly obese patients [mean (SD) age 37.2 (12) years, 89 females, 29 males] 30 age- sex-matched healthy...
In patients with chronic kidney disease (CKD) and type 2 diabetes (T2D), finerenone, a nonsteroidal mineralocorticoid receptor antagonist, reduces cardiovascular failure outcomes. Finerenone also lowers the urine albumin-to-creatinine ratio (UACR). Whether finerenone-induced change in UACR mediates outcomes is unknown.
Several epidemiological studies revealed sex-specific differences during oral glucose tolerance tests (OGTTs), such as higher prevalence of intolerance (i.e. increased at the end OGTT) in females, which was not yet explained. Thus, we aimed to analyze sex-related distinctions on OGTT metabolism, including gut absorption, healthy humans.Females (n = 48) and males 26) with comparable age (females, 45 ± 1 yr; males, 44 2 yr) body mass index (both, 25 kg/m(2)) but different height 166 cm; 180 P...
The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids components of other insulin-sensitivity indices but their measurement is expensive. Easier more affordable tools interest for both pediatric adult patients.Study participants from the Relationship Between Insulin Sensitivity Cardiovascular Disease [43.9 (8.3) years, n =...
The obesity epidemic might affect patients with type 1 diabetes (T1DM), historically described as lean and insulin-sensitive subjects. Insulin resistance in T1DM increase diabetic complications, especially cardiovascular disease. Therefore, the body mass index (BMI) was analyzed comparison to general population. Furthermore, impact of increased BMI on glycemic control metabolic alterations assessed.Body compared overall among four different age groups between adult (n = 186), treated...
Abstract —The increased incidence of cardiovascular diseases in obese subjects could be partially attributed to impaired fibrinolysis due elevated plasma levels tissue plasminogen activator inhibitor 1 (PAI-1). The associations between changes PAI-1, metabolic variables, and adipose during weight loss regain were studied 52 healthy, premenopausal, women participating a reduction program with hypocaloric diet. insulin, triglyceride, leptin, adipsin determined at entry, after the first week,...