A5076149583- Gestational Diabetes Research and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Pregnancy and preeclampsia studies
- Pituitary Gland Disorders and Treatments
- Diabetes Management and Education
- Birth, Development, and Health
- Adrenal and Paraganglionic Tumors
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Maternal and fetal healthcare
- Cardiovascular Function and Risk Factors
- Trace Elements in Health
- Infant Nutrition and Health
Mater Misericordiae University Hospital
2016-2025
University College Dublin
2017-2024
National Maternity Hospital
2014-2024
Sligo University Hospital
2024
Skåne University Hospital
2021
Beaumont Hospital
2010-2019
National Health Insurance Fund
2018
American Society for Reproductive Medicine
2018
University College Cork
2018
St. Vincent's University Hospital
2018
OBJECTIVE Type 2 diabetes is associated with insulin resistance and skeletal muscle mitochondrial dysfunction. We have found that subjects early-onset type show incapacity to increase Vo2max in response chronic exercise. This suggests a defect Here, we explored the nature of mechanisms involved. RESEARCH DESIGN AND METHODS Muscle biopsies were collected from young diabetic obese control before after acute or exercise protocols, expression genes and/or proteins relevant function was measured....
To evaluate the effect of a healthy lifestyle package (an antenatal behavior change intervention supported by smartphone application technology) on incidence gestational diabetes mellitus (GDM) in overweight and obese women.Women with body mass indexes (BMIs) 25-39.9 were enrolled into this randomized controlled trial. The consisted specific dietary exercise advice that addressed tailor-designed application. Women control group received usual care. primary outcome was GDM at 28-30 weeks...
Mitochondrial dysfunction is associated with insulin resistance and type 2 diabetes. It has thus been suggested that primary and/or genetic abnormalities in mitochondrial function may lead to accumulation of toxic lipid species muscle elsewhere, impairing action on glucose metabolism. Alternatively, however, defects signaling be events result dysfunction, or there a bidirectional relationship between these phenomena. To investigate this, we examined patients receptor (INSR) signaling. We...
The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance, because circulating lipid measurements are available in routine settings. Insulin, C-peptide, and free fatty acids components of other insulin-sensitivity indices but their measurement is expensive. Easier more affordable tools interest for both pediatric adult patients.Study participants from the Relationship Between Insulin Sensitivity Cardiovascular Disease [43.9 (8.3) years, n =...
OBJECTIVE Glucose measurements during an oral glucose tolerance test (OGTT) are useful in predicting diabetes and its complications. However, knowledge of the pathophysiology underlying differences curve shapes is sparse. We examined pathophysiological characteristics that create different patterns studied their stability reproducibility over 3 years follow-up. RESEARCH DESIGN AND METHODS analyzed data from participants without observational cohort European Group for Study Insulin...
There is a well-established association between type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) secondary to excess accumulation of intrahepatic lipid (IHL), but the mechanistic basis for this unclear. Emerging evidence suggests that in addition being associated with insulin resistance, NAFLD may be relative beta-cell dysfunction. We sought determine influence fat on hepatic extraction indices function cohort apparently healthy older white adults. performed cross-sectional...
Gestational diabetes (GDM) refers to glucose intolerance of varying severity first occurring in pregnancy. Following a diagnosis GDM, exercise and dietary modification has positive effect on improving glycemic control. Lifestyle changes affected pregnancies by GDM have beneficial effects long-term health if continued following birth. In addition, the psychological impact should not be overlooked. Reports maternal stress, anxiety, fear are commonly reported issues literature. Support, both...
The prevalence of type 2 diabetes (T2DM) is increasing rapidly and the age presentation falling. These changes are likely to be linked current obesity epidemic. Our objective was compare characteristics younger patients with T2DM (diagnosed at < 40 years) those older 50–70 years). We identified 149 T2DM, from our clinic database, compared them 217 randomly same database. Younger were more obese, hypertriglyceridaemic, lower high-density lipoprotein (HDL) cholesterol, higher total...
Early-onset type 2 diabetes (T2DM) may lead to very early vascular complications. Cardiovascular mortality is two five times higher in adults with than people without diabetes. The cardiovascular risk of young T2DM unknown. associated marked visceral obesity, insulin resistance and microalbuminuria. We recently showed that these subjects did not improve either fitness (maximum volume oxygen consumption, VO max) or glucose disposal after exercise training. Seven early-onset (aged 26.1±0.9...
Due to COVID-19, many centres adopted a change the diagnosis of GDM.A case-control study antenatal patients between 1 April and 30 June in 2019 2020 looking at detection rates GDM, use medication, obstetric, fetal outcomes.During rate positive GDM tests approximately halved (20% (42/210) vs. 42.2% (92/218) 2019, (p < 0.01)) with higher requirement for insulin (21.4% (2020) 2.2% (2019); p 0.01), term (31% 5.4% 0.01). metformin (4.8% 1.1% (14.3% 7.6% (2019) no differences birth outcomes.There...
Abstract Background/Objective: The present study tested the hypothesis that obesity-related changes in carotid intima-media thickness (IMT) might represent not only preclinical atherosclerosis but an adaptive remodeling meant to preserve circumferential wall stress (CWS) altered hemodynamic conditions characterized by body size-dependent increase stroke volume (SV) and blood pressure (BP). Subjects/Methods: Common artery (CCA) luminal diameter (LD), IMT CWS were measured three different...
Pre-gestational, type 1 and 2 diabetes are associated with adverse neonatal outcomes increased rates of emergency caesarean sections. We studied pregnancy pre-gestational in 174 women who attended the National Maternity Hospital Dublin, Ireland, between 2015 2017. Fifty (28.6%) had mellitus, 124 (71.4%) mellitus. Women mellitus were older (36 vs. 34 years, p 0.02) a higher BMI (32.6 26.2 kg/m2, 0.00). Duration was 15.7 5.7 respectively, mean HbA1c at booking 44.5 mmol/mol (6.2%) 56.3 (7.3%)....
Insulin resistance syndrome (IRS) of schoolchildren may contribute to cardiovascular diseases (CVD) young adults. The investigation different steps, baseline screening parameters and treatment IRS help the prevention.Schoolchildren (53 boys 61 girls age 5-17 years) because adverse family history CVD, hypertension, obesity were investigated. Patients divided into 3 groups according plasma glucose level (PGL) 120 180 min. after consumption (GC): (1) PGL < or = 5.5 mmol/L GC, (2) > but 7.8 GC...