A5016692061- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Thermoregulation and physiological responses
- Coronary Interventions and Diagnostics
- Hormonal Regulation and Hypertension
- Non-Invasive Vital Sign Monitoring
- Cardiac, Anesthesia and Surgical Outcomes
- Infrared Thermography in Medicine
- Lipoproteins and Cardiovascular Health
- Renal and Vascular Pathologies
- Cardiovascular Effects of Exercise
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Diet and metabolism studies
- Cardiac Arrhythmias and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Artery Disease Management
University of Pisa
2016-2025
Universidad de Guadalajara
2024
University of Florence
2021
Malmö University
2020
Fondazione Toscana Gabriele Monasterio
2017
NIHR Exeter Clinical Research Facility
2015
Lund University
2015
University of Exeter
2015
University of Dundee
2015
Ospedale Santa Chiara
2014
The effects of simulated microgravity on the static and dynamic properties large arteries are still mostly unknown. present study evaluated, using an integrated vascular approach, changes in structure function common carotid femoral (CCA CFA) after prolonged head-down tilt bed rest (HDTBR). Ten healthy men were enrolled a 5-week HDTBR endorsed by Italian Space Agency (ASI). Arterial geometry, flow, stiffness, shear rate evaluated ultrasound. Local pulse pressure wave reflection studied...
Subclinical hypothyroidism (sHT) is associated with dyslipidemia and enhanced cardiovascular risk. We assessed carotid artery intima-media thickness (IMT, high-resolution ultrasonography) lipoprotein profile in 45 sHT patients (aged 37 +/- 11 yr) at baseline after 6 months of randomized, placebo-controlled L-T(4) replacement. In comparison 32 age- sex-matched controls, had elevated total low-density (LDL) cholesterol ApoB levels (P = 0.002, P 0.0007, 0.01, respectively) higher mean-IMT...
Background —AMI reperfusion by thrombolysis does not improve TIMI flow and LV function. The role of infarct-related artery (IRA) stenosis superimposed changes in coronary vasomotor tone maintaining dysfunction must be elucidated. Methods Results —Forty patients underwent diagnostic angiography 24 hours after thrombolysis. Seventy-two thrombolysis, the culprit lesion was dilated with stenting. During angioplasty, function monitored transesophageal echocardiography. Percent regional systolic...
Arterial hypertension is frequently associated with the presence of structural alterations in small arteries. Moreover, a reduced coronary flow reserve and vasodilator capacity has been observed essential hypertensive patients, possibly due, at least part, to microangiopathy vessels. The aim present study was evaluate possible relationship between subcutaneous artery structure or patients hypertension.A total 20 mild moderate were included study, underwent biopsy fat from gluteal region....
An association between fatty liver and carotid atherosclerosis has been established; however, it is not clear whether this relationship a consequence of shared conventional risk factors or determined by specific circulating originating from adipose tissue. To identify the possibly linking atherosclerosis, we assessed, in 1,012 subjects free confounding diseases (e.g., hypertension, diabetes, cardiovascular diseases, dyslipidemia) metabolic syndrome, presence early plaques at bifurcation...
Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development tissue repair. They have also been shown to both protective pathogenic effects atherosclerosis, experimental studies suggested that MMP-12 contributes plaque growth destabilization. The objective of this study was investigate the associations between circulating MMPs, atherosclerosis burden, incidence cardiovascular disease with a particular focus on type 2 diabetes mellitus.Plasma...
Previous studies have shown that essential hypertension is frequently associated with insulin resistance. The tissues responsible for this metabolic alteration not been defined. We tested the hypothesis skeletal muscle site of resistance use perfused forearm technique. Eight hypertensive (age 42 +/- 3 years, body mass index 27 1 kg/m2, intra-arterial mean blood pressure 126 4 mm Hg) and seven normotensive 48 26 95 male volunteers were studied. After glucose ingestion (40 g/m2), normal...
The relationship between dyslipidemia, inflammation and CV organ damage in type 2 diabetes mellitus (T2DM) is complex. Insulin resistance inflammatory cytokines interleukins (ILs) increase plasma triglycerides (TG). ILs also up-regulate expression of matrix-metalloproteinases (MMPs) that, together with TG, decrease high density lipoprotein cholesterol (HDL) levels. High low HDL, increased MMPs trigger structural functional changes different parts cardiovascular (CV) system. To understand...
The purpose of this study was to investigate the different mechanisms responsible for an impairment coronary vasodilator capacity in hypertensive subjects by integrated echocardiographic approach, including transesophageal Doppler echocardiography, which allows noninvasive monitoring flow velocity left anterior descending artery during pharmacological vasodilation. population consisted 17 healthy control and 33 subjects: 10 without hypertrophy, 16 with mild moderate 7 severe ventricular...
The relation between the renin-angiotensin-aldosterone (RAA) system and carbohydrate metabolism insulin sensitivity in essential hypertension has not been investigated systematically. Twenty nondiabetic patients (age, 49 +/- 1 years; body mass index (BMI), 26.1 0.4 kg/m2) with (blood pressure, 155 3/105 mm Hg) received an oral glucose tolerance test (OGTT) at end of a 1-month placebo period again monthly during 3 months angiotensin converting enzyme (ACE) inhibition (cilazapril, 5 mg/day)....
This study investigated whether sedentary behaviour and different activity levels have an independent association with carotid intima-media thickness (IMT) the 3-year IMT progression in segments.The population included 614 healthy men women (mean age = 44 +/- 8 years) without atherosclerosis increased coronary heart disease risk, who underwent B-mode ultrasound objective physical assessment by accelerometer monitoring time 5.7 1.5 days). Time spent (57.6 9.1%), light (41.0 9.2%), moderate...
Carotid intima-media thickness (IMT), indices of large artery stiffness and measures endothelium function may be used as markers early atherosclerosis in type 1 diabetes mellitus (T1DM). The aim the present study was to compare structure well endothelial regenerating capacity between adolescents with T1DM healthy control similar age. In addition, associations different vascular progenitor cells (EPCs), glyco-metabolic serum levels advanced glycation endproducts (AGEs), soluble receptors for...
Several studies showed a positive association between heart rate and pulse wave velocity, sensitive marker of arterial stiffness. However, no study involving large population has specifically addressed the dependence velocity on different components cardiac cycle. The aim this was to explore in subjects age link with period (the reciprocal rate) temporal cycle such as left ventricular ejection time diastolic time. Carotid-femoral assessed 3,020 untreated (1,107 men). Heart period, time,...
Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute development vascular complications in type 2 diabetes (T2D). The aim present study was determine if plasma renin levels are associated with severity changes subjects and without T2D. Renin analyzed by Proximity Extension Assay (n = 985) 515) T2D participating SUMMIT (SUrrogate markers for Micro- Macro-vascular hard endpoints Innovative Tools) 205 carotid endarterectomy patients. Vascular were...
Poor glycemic control is associated with impaired left ventricular (LV) diastolic function in patients type 2 diabetes mellitus (T2DM). Inappropriate LV mass increase and accelerated aortic stiffening were suggested to participate on deterioration of function. The present study investigated the inter-relationships between control, early systolic longitudinal velocity mitral annulus, stiffness T2DM free cardiovascular disease preserved ejection fraction, compared them those observed healthy...
Interaction between arterial stiffness and hypertension plays an important role in the development of cardiovascular disease. Accordingly, assessment may provide a tool for estimating risk monitoring therapy hypertensive patients. Radiofrequency-based vascular ultrasound allows accurate noninvasive local mechanical properties large arteries, but its use clinical practice, reference values according to age sex are mandatory each site. To common carotid artery as assessed by echo-tracking...
Objectives: The aim of the study was to evaluate role central pulse pressure (PP) in carotid wall thickening and coronary artery calcification (CAC). Methods: In an asymptomatic general population ( N = 396, 163 men, 47–89 years), PP measured by applanation tonometry, CAC computed tomography, common intima–media thickness (cIMT), wave velocity (cPWV) power signal reflected from media (cMP) radiofrequency-based ultrasound. High cIMT defined as equal or greater than 75th percentile for given...
Insulin-mediated vasodilation has been proposed as a determinant of in vivo insulin sensitivity. We tested whether sustained with adenosine could overcome the muscle resistance present mildly overweight patients essential hypertension. Using forearm technique, we measured response to 40-min local intraarterial infusion given under fasting conditions (n = 6) or superimposed on euglycemic clamp 8). In state, adenosine-induced (forearm blood flow from 2.6 +/- 0.6 6.0 1.2 ml min-1dl-1, P <...
To investigate the seasonal influences on various arterial blood pressure measurements, 22 subjects in high normal to mild hypertensive range were examined twice following same protocol. In one group (13 subjects), measurements first done warm conditions and repeated 5-7 months later cold conditions; second (nine subjects) a reverse sequence was followed. Blood measured under casual during hand grip exercise test, mental arithmetic submaximal multistage bicycle test; 24 hours, serially with...