A5018897167- Parathyroid Disorders and Treatments
- Healthcare Systems and Practices
- Thyroid and Parathyroid Surgery
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Epigenetics and DNA Methylation
- Pharmacological Effects and Toxicity Studies
- Health, Medicine and Society
- Renal cell carcinoma treatment
- Bone health and treatments
- Renal and related cancers
- Hemoglobinopathies and Related Disorders
- Potassium and Related Disorders
- Kidney Stones and Urolithiasis Treatments
- Healthcare cost, quality, practices
- Pediatric Urology and Nephrology Studies
- Thyroid Cancer Diagnosis and Treatment
- Vitamin K Research Studies
- Magnesium in Health and Disease
- Dialysis and Renal Disease Management
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- Erythrocyte Function and Pathophysiology
Pitié-Salpêtrière Hospital
2021-2025
Sorbonne Université
2021-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
The University of Texas MD Anderson Cancer Center
2019-2025
Hôpital Tenon
2023
Université Sorbonne Nouvelle
2023
Université Paris Cité
2015-2023
Centre de Recherche des Cordeliers
2011-2023
Inserm
2010-2023
Hôpital Européen Georges-Pompidou
2015-2021
This European expert consensus statement provides recommendations for the diagnosis and management of primary hyperparathyroidism (PHPT), chronic hypoparathyroidism in adults (HypoPT), parathyroid disorders relation to pregnancy lactation. Specified areas interest unmet needs identified by experts at second ESE Educational Program Parathyroid Disorders (PARAT) 2019, were discussed during two virtual workshops 2021, subsequently developed working groups with specified areas. PHPT is a common...
Familial hypocalciuric hypercalcemia (FHH) is a genetically heterogeneous condition resembling primary hyperparathyroidism (PHPT) but not curable by surgery; FHH types 1, 2, and 3 are due to loss-of-function mutations of the CASR, GNA11, or AP2S1 genes, respectively.This study aimed compare phenotypes patients with proven 1 PHPT.This was mutation analysis in large cohort, cross-sectional comparison 52 type 22 3, 60 PHPT, 24 normal adults.There were no interventions.Abnormalities blood...
Background At the end of 2023, Bayer AG launched its own internal large language model (LLM), MyGenAssist, based on ChatGPT technology to overcome data privacy concerns. It may offer possibility decrease their harshness and save time spent repetitive recurrent tasks that could then be dedicated activities with higher added value. Although there is a current worldwide reflection whether artificial intelligence should integrated into pharmacovigilance, medical literature does not provide...
Abstract Chronic hypoparathyroidism is a rare disease associated with an impaired quality of life. Recommendations suggest frequent monitoring life, but for French-speaking people, only generic scales are available despite the fact that chronic has specific symptoms and impact. The aim this study was to adapt validate French version Hypoparathyroid Patient Questionnaire 28 (HPQ28), already validated tool in patients living hypoparathyroidism, English German. HPQ28 translated back-translated...
Abstract Purpose: Renal medullary carcinoma (RMC) is a highly aggressive malignancy defined by the loss of SMARCB1 tumor suppressor. It mainly affects young individuals African descent with sickle cell trait, and it resistant to conventional therapies used for other renal carcinomas. This study aimed identify potential biomarkers early detection disease monitoring RMC. Experimental Design: Integrated profiling primary untreated RMC tissues paired adjacent kidney controls was performed using...
<div>AbstractPurpose:<p>Renal medullary carcinoma (RMC) is a highly aggressive malignancy defined by the loss of SMARCB1 tumor suppressor. It mainly affects young individuals African descent with sickle cell trait, and it resistant to conventional therapies used for other renal carcinomas. This study aimed identify potential biomarkers early detection disease monitoring RMC.</p>Experimental Design:<p>Integrated profiling primary untreated RMC tissues paired adjacent...
<p>This pdf file contains Supplementary Figures S1-S5 and their legends.</p>
<p>The supplementary methods file contains additional details on the chromatin extraction and immuno-precipitation sequencing approaches.</p>
Abstract Context Parathyroid-related hypercalcemia is due to primary hyperparathyroidism (PHPT) or familial hypocalciuric (FHH). PHPT can lead complications that necessitate parathyroidectomy. FHH a rare genetic disease resembling PHPT; surgery ineffective. A reliable method for distinguishing from needed. Objective To develop an easy-to-use tool predict if patient has PHPT. Design Retrospective analysis of two prospective cohorts. Development unsupervised risk equation (Pro-FHH). Setting...
In the last 2 decades, new technologies have emerged in health care. The COVID-19 pandemic further accelerated adoption of technology by both care professionals and patients. These create remote practices that bring several benefits to system: easier access care, improved communication with physicians, greater continuity However, disparities acceptance use telehealth tools still exist among also disrupt conventional medical prompt a reassessment perceptions distance proximity as physical...
The value of estimated glomerular filtration rate (eGFR) in living kidney donors screening is unclear. A recently published web-based application derived from large cohorts, but not donors, calculates the probability a measured GFR (mGFR) lower than determined threshold. Our objectives were to validate clinical utility this tool cohort and test two other strategies based on chronic disease epidemiology collaboration (CKD-EPI) MDRD-eGFR. was using 51Cr- ethylene-diamine tetraacetic acid...
Methyl marks made by the epigenetic writer SETD2 recruit reader PBRM1 to spindle microtubules during mitosis.
Renal medullary carcinoma (RMC) is a lethal malignancy affecting individuals with sickle hemoglobinopathies. Currently, no modifiable risk factors are known. We aimed to determine whether high-intensity exercise factor for RMC in cell trait (SCT). used multiple approaches triangulate our conclusion. First, case-control study was conducted at single tertiary-care facility. Consecutive patients were compared matched controls similarly advanced genitourinary malignancies 1:2 ratio and on rates...
Background Hypertension is highly prevalent during chronic kidney disease ( CKD ) and, in turn, worsens prognosis. We aimed to describe the determinants of uncontrolled and resistant hypertension . Methods Results analyzed baseline data from patients with stage 1 5 (NephroTest cohort) who underwent thorough renal explorations, including measurements glomerular filtration rate (clearance 51 Cr‐EDTA) extracellular water (volume distribution tracer). was defined as blood pressure BP ; average 3...