A5010700999- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Bipolar Disorder and Treatment
- Electrolyte and hormonal disorders
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- Kidney Stones and Urolithiasis Treatments
- Ion Transport and Channel Regulation
- Renal and related cancers
- Renal and Vascular Pathologies
- Cardiovascular Health and Disease Prevention
- Magnesium in Health and Disease
- Renal cell carcinoma treatment
- Medical Imaging and Pathology Studies
- Pregnancy and Medication Impact
- Hemodynamic Monitoring and Therapy
- MRI in cancer diagnosis
- Organ Donation and Transplantation
- Thyroid and Parathyroid Surgery
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Transplantation Outcomes and Treatments
- Muscle and Compartmental Disorders
- Biomedical Research and Pathophysiology
- Gout, Hyperuricemia, Uric Acid
Université Paris Cité
2017-2024
Assistance Publique – Hôpitaux de Paris
2017-2024
Hôpital Bichat-Claude-Bernard
2018-2024
Inserm
2013-2024
Centre de Recherche des Cordeliers
2021-2024
Sorbonne Université
2015-2024
Hackensack Meridian Health
2024
University Medical Center
2024
Metabolism and Renal Physiology
2022-2024
Harvard University
2023-2024
High-throughput drug screening is crucial for advancing healthcare through discovery. However, a significant limitation arises from availablein vitromodels using conventional 2D cell culture, which lack the proper phenotypes and architectures observed in three-dimensional (3D) tissues. Recent advancements stem biology have facilitated generation of organoids-3D tissue constructs that mimic human organsin vitro. Kidney organoids, derived pluripotent cells, represent breakthrough disease...
Monocytes have a crucial role in both proinflammatory and anti-inflammatory phenomena occurring during sepsis. Monocyte recruitment activation are orchestrated by the chemokine receptors CX3CR1 CCR2 their cognate ligands. However, little is known about roles of these cells chemokines acute phase inflammation Using intravital microscopy murine model polymicrobial sepsis, we showed that inflammatory Ly6C(high) monocytes infiltrated kidneys, exhibited altered motility, adhered strongly to renal...
Urinary biomarkers may improve the prediction of chronic kidney disease (CKD) progression. Yet, data reporting applicability most commercial biomarker assays to detection their target analyte in urine together with an evaluation predictive performance are scarce.30 (ELISA) were tested for ability quantify using strict (FDA-approved) validation criteria. In exploratory analysis, LASSO (Least Absolute Shrinkage and Selection Operator) logistic regression analysis was used identify potentially...
Optimal parathyroid hormone (PTH) control during non-dialysis chronic kidney disease (ND-CKD) might decrease the subsequent risk of hyperplasia and uncontrolled secondary hyperparathyroidism (SHPT) on dialysis. However, evidence for recommending PTH targets therapeutic strategies is weak ND-CKD. We evaluated patient characteristics, treatment patterns over first year haemodialysis (HD) by prior to HD initiation.
Objectives: Optimal blood pressure (BP) control is key to prevent cardiovascular complications in patients with chronic kidney disease (CKD). We described the prevalence and factors associated masked hypertension CKD. Methods: analyzed 1113 ambulatory 24-h BP monitoring (ABPM) records of 632 referred for function evaluation. Masked was defined as office less than 140/90 mmHg but daytime at least 135/85 or nighttime 120/70 mmHg. Factors were assessed mixed logistic regression models. Results:...
Recent advances in stem cell research have led to the creation of organoids, miniature replicas human organs, offering innovative avenues for studying diseases. Kidney with their ability replicate complex renal structures, provide a novel platform investigating kidney diseases and assessing drug efficacy, albeit hindered by labor-intensive generation batch variations, highlighting need tailored cryopreservation methods enable widespread utilization. Here, we evaluated strategies organoids...
Available treatments for multiple sclerosis (MS) require frequent injections and have significant side effects. Proteases generated during inflammation are involved in the induction of tissue damage inflammatory demyelination central nervous system (CNS). The Bowman-Birk Inhibitor (BBI), a soy-derived protease inhibitor with anti-carcinogenic anti-inflammatory properties, has been shown to be well tolerated clinical trials pre-cancerous conditions, such as oral leukoplakia disease,...
Background Hypertension is highly prevalent during chronic kidney disease ( CKD ) and, in turn, worsens prognosis. We aimed to describe the determinants of uncontrolled and resistant hypertension . Methods Results analyzed baseline data from patients with stage 1 5 (NephroTest cohort) who underwent thorough renal explorations, including measurements glomerular filtration rate (clearance 51 Cr‐EDTA) extracellular water (volume distribution tracer). was defined as blood pressure BP ; average 3...
MYH9-related diseases (MYH9-RD) are autosomal dominant disorders caused by mutations of the MYH9 gene encoding non-muscle myosin heavy chain IIA. They characterized congenital thrombocytopenia, giant platelets and leucocyte inclusions. Hearing impairment, pre-senile cataract nephropathy can also occur. We aimed to evaluate renal involvement outcome in MYH9-RD patients followed-up nephrologists.We conducted a retrospective multicentre observational study 13 among 9 families with mutation...
Green tea is widely used as a ‘’healthy’’ beverage due to its high level of antioxidant polyphenol compounds. However also known contain significant amount oxalate. The objective was determine, in cross-sectional observational study among population 273 hypercalciuric stone-formers referred our center for metabolic evaluation, whether daily green drinkers (n = 41) experienced increased stone risk factors (especially oxalate) compared non-drinkers. Stone and composition were analyzed...
Objectives: Early kidney damage during lithium treatment in bipolar disorder is still hypothetical. We aimed at identifying the determinants of a decreased measured glomerular filtration rate (mGFR) and accuracy MRI imaging its detection. Methods: In this cross-sectional cohort study, 217 consecutive lithium-treated patients underwent mGFR with half-Fourier turbo spin-echo Single-shot long echo time sequences. Results: Median age was 51 [27-62] years, median duration 5 [2-14] years. 52% had...
BACKGROUND Augmented renal creatinine clearance (ARC) (≥130 ml min −1 1.73 m −2 ) is frequent in intensive care unit (ICU) patients and may impact patient outcome. OBJECTIVES To compare glomerular filtration rate (GFR) measured with iohexol plasma critically ill augmented clearance. DESIGN Single-centre, retrospective study. SETTING French University Hospital ICU from November 2016 to May 2019. PATIENTS Adult who had a measurement of MAIN OUTCOME MEASURE Agreement between 6 h (6 CrCl)...
Abstract Lithium induces nephrogenic diabetes insipidus (NDI) and microcystic chronic kidney disease (CKD). As previous clinical studies suggest that NDI is dose‐dependent CKD time‐dependent, we investigated the effect of low exposition to lithium in a long‐term experimental rat model. Rats were fed with normal diet (control group), addition (Li + or amiloride /Ami group) for 6 months, allowing obtaining plasma concentrations (0.25 ± 0.06 0.43 0.16 mmol/L, respectively). Exposition levels...
Summary The management of sickle cell nephropathy (SCN) at an early stage is important issue to prevent renal and cardiovascular morbidity mortality. This study aimed evaluate in this population, whether angiotensin converting enzyme inhibitors (ACEIs) treatment could exert a cardio‐renal protection SCN cohort. Forty‐two patients (urine albumin:creatinine ratio (ACR) > 10 mg/mmol) were treated with ACEIs for 6 months, then evaluated ACR, measured glomerular filtration rate (mGFR) together...
Background Aortic stiffness assessed by carotid-femoral pulse wave velocity (CF-PWV) is a predictor of mortality in several populations. However, little known kidney transplant recipients. Our objectives were to evaluate the ability CF-PWV measured 3 months following transplantation predict mortality, graft loss and its potential links Glomerular Filtration Rate (mGFR) or microvasculature parameters. Methods The study based on monocentric retrospective cohort including 220 adult recipients...
Abstract Severe hypertension can lead to malignant (MH) with renal thrombotic microangiopathy and hemolysis. The role of plasma heme release in this setting is unknown. We aimed at evaluating the effect a mild increase by hemin administration angiotensin II (AngII)-mediated hypertensive rats. Prevalence MH blood pressure values were similar AngII + groups. rats displayed decreased flow (RBF), increased vascular resistances (RVR), aorta interlobar arteries remodeling severe microcirculation...
Most mouse kidney stone models induce nephrocalcinosis rather than urolithiasis. The aim of our study was to find an accelerated experimental model in order the early events formation, that is, at time crystal binding intrarenal urothelium. C57B6 mice exposed vitamin D supplements and water containing hydroxyl-L-proline, ammonium chloride calcium were studied for 42 days. A group receiving urothelial cell mitogen Fibroblast Growth Factor 7 (FGF7) compared control saline. Calcium oxalate...
Lithium treatment can induce nephrogenic diabetes insipidus (NDI), but no consensus intervention is offered to date. We evaluated in these patients patterns of urine concentration and the correlates 24-hour output.Prospective, single-center, observational study 217 consecutive lithium-treated individuals, with collection, desmopressin (1-deamino-arginine vasopressin [DDAVP]) concentrating test, fasting plasma measurement (copeptin n = 119), measured glomerular filtration rate (mGFR). Maximal...