A5039428617- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Inflammatory Bowel Disease
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Electrolyte and hormonal disorders
- COVID-19 Clinical Research Studies
- Renal function and acid-base balance
- Microscopic Colitis
- Cell Adhesion Molecules Research
- Bipolar Disorder and Treatment
- Long-Term Effects of COVID-19
- Muscle and Compartmental Disorders
- Ion Transport and Channel Regulation
- Renal Transplantation Outcomes and Treatments
- Bone health and treatments
- Pharmacological Effects and Toxicity Studies
- Pediatric Urology and Nephrology Studies
- Platelet Disorders and Treatments
- Potassium and Related Disorders
- Iron Metabolism and Disorders
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
Clinique Jules Verne
2019-2025
Hôpital Bichat-Claude-Bernard
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Inserm
2015-2024
Université Paris Cité
2015-2024
Centre de Recherche sur l'Inflammation
2015-2024
Centre de Recherche des Cordeliers
2023-2024
Sorbonne Paris Cité
2011-2023
Université Gustave Eiffel
2023
Université Claude Bernard Lyon 1
2012-2022
We recently published and validated the new serum creatinine (Scr)-based full-age-spectrum equation (FAS crea ) for estimating glomerular filtration rate (GFR) healthy kidney-diseased subjects of all ages. The was based on concept normalized Scr shows equivalent to superior prediction performance currently recommended equations children, adolescents, adults older adults.Based an evaluation cystatin C (ScysC) distribution, we defined normalization constants ScysC ( Q cysC = 0.82 mg/L ages <70...
The accuracy of estimation kidney function with the use routine metabolic tests, such as measurement serum creatinine level, has been controversial. European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate glomerular filtration rate (GFR) rescaled level (i.e., is divided by median among healthy persons control for variation related differences in age, sex, or race). Whether cystatin C-based EKFC would increase estimated GFR unknown. We used...
Hypertension is associated with vascular remodeling characterized by rearrangement of extracellular matrix proteins. To evaluate how metalloproteinase (MMP)-9 contributes to the progression hypertensive disease in vivo, wild-type (wt) or MMP-9 −/− mice were treated angiotensin II (Ang II; 1 μg/kg per minute, minipump) plus a 5% NaCl diet during 10 days. Baseline blood pressure was equivalent wt and knockout mice, but Ang treatment increased systolic greater extent ( P <0.05) (94±6 134±6...
IgA nephropathy (IgAN) is a common cause of renal failure worldwide. Treatment limited because complex pathogenesis, including unknown factors favoring IgA1 deposition in the glomerular mesangium. receptor abnormalities are implicated, circulating IgA–soluble CD89 (sCD89) complexes and overexpression mesangial receptor, TfR1 (transferrin 1). Herein, we show that although mice expressing both human displayed deposits IgA1–sCD89 resulting kidney inflammation, hematuria, proteinuria, only...
Disorders of mineral and bone metabolism are prevalent in patients with chronic kidney disease (CKD). The recent National Kidney Foundation Disease Outcomes Quality Initiative (K/DOQI) guidelines recommend that blood calcium (Ca) be regularly measured stages 3 to 5 CKD. Disease: Improving Global (KDIGO) position states the measurement ionized Ca (iCa) is preferred if total (tCa) concentration used instead, then it should adjusted setting hypoalbuminemia. In 691 consecutive CKD, we compared...
Recent studies suggest that alkalinizing treatments improve the course of chronic kidney disease (CKD), even in patients without overt metabolic acidosis. Here, we tested whether a decreased ability excreting urinary acid rather than acidosis may be deleterious to CKD. We studied associations between baseline venous total CO2 concentration or ammonia excretion and long-term CKD outcomes 1065 NephroTest cohort with stages 1–4. All had measured glomerular filtration rate (mGFR) by 51Cr-EDTA...
UMOD mutations cause familial juvenile hyperuricemic nephropathy (FJHN) and medullary cystic kidney disease (MCKD), although these phenotypes are nonspecific.We reviewed cases of diagnosed in the genetic laboratories Necker Hospital (Paris, France) Université Catholique de Louvain (Brussels, Belgium). We also analyzed patients with MCKD/FJHN but no mutation. To determine thresholds for hyperuricemia uric-acid excretion fraction (UAEF) according to GFR, parameters were 1097 various renal...
A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This neither validated outside USA nor compared with European Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in cohorts.Standardized creatinine measured glomerular filtration rate (GFR) from EKFC cohorts (n = 13 856 including 6031 individuals external validation cohort), France 4429, 964 Black Europeans), Brazil 100) Africa 508)...
A frequent complication of hypertension is the development chronic renal failure. This pathology usually initiated by inflammatory events and characterized abnormal accumulation collagens within tissue. The purpose this study was to investigate role discoidin domain receptor 1 (DDR1), a nonintegrin collagen that displays tyrosine-kinase activity, in fibrosis. To end, induced with angiotensin mice were genetically deficient DDR1 wild-type controls. After 4 or 6 wk II administration, developed...
In Brief Background The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of glomerular filtration rate (GFR) by Modification Diet in Renal (MDRD) Study patients with a relatively well-preserved kidney function. performance for transplant recipients is discussed. Methods We analyzed performances CKD-EPI comparison MDRD 825 stable recipients. Bias, precision, and accuracy within 30% true GFR were...
Abstract The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury kidney failure. Here we show that expression tetraspanin CD9 increases markedly PECs mouse models CGN FSGS, kidneys from individuals diagnosed with these diseases. Cd9 gene targeting prevents damage...
Hypertension is frequently associated with the development of renal vascular and glomerular fibrosis. The purpose present study was to investigate whether epidermal growth factor receptor (EGFR) activation participates in fibrosis test if blockade EGFR would have therapeutic effects. Experiments were performed during nitric oxide (NO) deficiency-induced hypertension rats (L-NAME model). After 4 weeks L-NAME treatment, animals developed deterioration structure function. Over same period,...
Anemia in patients with CKD is highly related to impaired erythropoietin (EPO) response, the timing and determinants of which remain unknown.This study measured EPO levels studied their relation GFR by 51Cr-EDTA renal clearance (mGFR) 336 all-stage not receiving any erythropoiesis-stimulating agent.In anemia defined World Health Organization criteria (hemoglobin [Hb] <13 g/dl men 12 women), response Hb level varied mGFR level. were negatively correlated (r=-0.22, P=0.04) when was >30 ml/min...
The metabolism of hepcidin is profoundly modified in chronic kidney disease (CKD). We investigated its relation to iron disorders, inflammation and hemoglobin (Hb) level 199 non-dialyzed, non-transplanted patients with CKD stages 1–5. All had their glomerular filtration rate measured by 51Cr-EDTA renal clearance (mGFR), as well measurements markers including erythropoietin (EPO). Hepcidin varied from 0.2 193 ng/mL. median increased 23.3 ng/mL [8.8–28.7] 36.1 [14.1–92.3] when mGFR decreased...