A5041177524- Allergic Rhinitis and Sensitization
- Health, Medicine and Society
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Pain Management and Placebo Effect
- Musculoskeletal pain and rehabilitation
- Alkaline Phosphatase Research Studies
- Renal Diseases and Glomerulopathies
- Tissue Engineering and Regenerative Medicine
- Prostate Cancer Treatment and Research
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Selenium in Biological Systems
- Animal Genetics and Reproduction
- Heterotopic Ossification and Related Conditions
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Xenotransplantation and immune response
- Peptidase Inhibition and Analysis
- Chronic Kidney Disease and Diabetes
- Quinazolinone synthesis and applications
- Hormonal and reproductive studies
- Coccidia and coccidiosis research
Université Paris Cité
2017-2024
Inserm
2013-2024
Paris Cardiovascular Research Center
2017-2024
Hôpital Européen Georges-Pompidou
2021
Translational Research in Oncology
2021
Sorbonne Université
2020
Assistance Publique – Hôpitaux de Paris
2020
Institut Curie
2015-2019
Université Paris Sciences et Lettres
2019
Délégation Paris 5
2017
The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of American Society Histocompatibility and Immunogenetics Pittsburgh, PA (USA) focused on refining recent updates to classification, advances from working groups, standardization molecular diagnostics. This report kidney transplant details clarifications refinements criteria chronic active (CA) T cell–mediated rejection (TCMR), borderline, antibody-mediated (ABMR). main focus sessions how address...
This meeting report from the XV Banff conference describes creation of a multiorgan transplant gene panel by Molecular Diagnostics Working Group (MDWG). Human Organ Transplant (B-HOT) is culmination previous work MDWG to identify broadly useful based on whole transcriptome technology. A data-driven process distilled list peer-reviewed comprehensive microarray studies that discovered and validated their use in kidney, liver, heart, lung biopsies. These were supplemented genes define relevant...
Abstract Background The COVID-19 pandemic has severely affected health systems and medical research worldwide but its impact on the global publication dynamics non-COVID-19 not been measured. We hypothesized that may have impacted scientific production of research. Methods conducted a comprehensive meta-research studies (original articles, letters case reports) published between 01/01/2019 01/01/2021 in 10 high-impact infectious disease journals (New England Journal Medicine, Lancet,...
Abstract The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury kidney failure. Here we show that expression tetraspanin CD9 increases markedly PECs mouse models CGN FSGS, kidneys from individuals diagnosed with these diseases. Cd9 gene targeting prevents damage...
Sublingual immunotherapy (SLIT) applied to type I respiratory allergies is commonly performed with natural allergen extracts. Herein, we developed a sublingual tablet made of pharmaceutical-grade recombinant Bet v 1.0101 (rBet 1) and investigated its clinical safety efficacy in birch pollen (BP)-allergic patients.Following expression Escherichia coli purification, rBet 1 was characterized using chromatography, capillary electrophoresis, circular dichroism, mass spectrometry crystallography....
To select the appropriate patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), it is important to gain a better understanding of intracellular pathways leading EGFR-TKI resistance, which common problem in lung cancer. We recently reported that mutant KRAS adenocarcinoma resistant gefitinib as result amphiregulin and insulin-like factor-1 overexpression. This resistance leads inhibition Ku70 acetylation, thus enhancing BAX/Ku70 interaction...
Background The minimally important difference (MID) has been defined as the smallest improvement considered worthwhile by a patient. MID not estimated for Rhinoconjunctivitis Total Symptom Score (RTSS). Methods In prospective multicentre study, patients consulting grass-pollen-induced allergic rhinitis (AR) recorded 15-point global rating of change scale (GRCS) score and Quality Life Questionnaire (RQLQ) on weekly basis individual symptom scores comprising RTSS daily over two consecutive...
Follicle-stimulating hormone receptor (FSHR) is expressed on the endothelial surface of blood vessels associated with solid tumor periphery, where angiogenesis known to occur. The correlation between FSHR expression and formation new peritumoral has not been previously investigated.We used immunohistochemical techniques involving specific antibodies detect markers (CD34, VEGFR2, D2-40) in tissue samples from 83 patients lymph node-negative, invasive breast cancer representing four main...
The strong predictive value of proteinuria in chronic glomerulopathies is firmly established as well the pathogenic role angiotensin II promoting progression glomerular disease with an altered filtration barrier, podocyte injury and scarring glomeruli. Here we found that II-induced hypertension inhibited autophagy flux mouse Deletion Atg5 (a gene encoding a protein involved autophagy) specifically resulted accelerated podocytopathy, accentuated albuminuria glomerulosclerosis. This indicates...
Hypophosphatasia is a rare inherited disorder characterized by defective bone mineralization and deficiency of serum tissue liver/bone/kidney alkaline phosphatase (L/B/K ALP) activity. We report here the characterization tissue-nonspecific (TNSALP) gene mutations in series 11 families affected various forms hypophosphatasia. Nineteen distinct were found, 7 which previously reported. Eleven 12 new missense (Y11C, A34V, R54H, R135H, N194D, G203V, E218G, D277Y, F310G, A382S, V406A), last one...
FSGS, the most common primary glomerular disorder causing ESRD, is a complex disease that only partially understood. Progressive sclerosis hallmark of and genetic tracing studies have shown parietal epithelial cells participate in formation sclerotic lesions. The loss podocytes triggers focal activation cells, which subsequently form cellular adhesions with capillary tuft. However, absence intrinsic podocyte alterations, origin pathogenic signal cell recruitment remains elusive. In this...
from teaching and research institutions in France or abroad, public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.
Tissue-based gene expression profiling can detect disease before it is visible from histology, more precisely capture activity, stage, and degree of injury, has been shown to improve histology-based diagnosis antibody-mediated rejection (AMR) T-cell mediated (TCMR) in kidney allografts.(1–3)
STUDY OBJECTIVE - The aim of the study was to assess value triphenyltetrazolium chloride (TTC) staining as an indicator non-viable myocardium after early reperfusion ischaemic myocardium. DESIGN Left anterior descending artery occlusion performed in pigs for various lengths time and at two different sites (proximal distal). After 120 min reperfusion, TTC injected distal while remainder stained with Evans Blue. Myocardial enzymes were measured non-ischaemic zone, regions risk necrotic zones...
Objective. Indirect evidence suggests a role for heme oxygenase-1 (HO-1) in limiting diabetic vasculopathy. The goal of this study was to assess the HO-1 development microvascular lesions within glomeruli during diabetes mellitus using mouse model with specific alteration Hmox1 gene. Approach and Results. effects haploinsufficiency were studied as means assessing intrinsic contribution renal diabetes. Renal function histology analyzed 10 weeks after induction streptozotocin. Diabetic +/−...
Perineural invasion (PNI) is generally accepted as a major route of cancer dissemination in malignancies associated with highly enervated organs. However, the effect cells on vasa nervorum remains unknown. We studied this locally advanced prostate cancer, high-risk feature approximately 20% specific mortality.We used immunohistochemistry for CD34, fibroblast growth factor-2 (FGF-2), FSHR, podoplanin, vascular endothelial factor (VEGF), and VEGFR-2 well histochemical methods to examine nerves...
Background and aims Tissular gene expression profiling has the potential to refine diagnosis of cardiac allograft rejection. Contrary whole-transcriptome approaches, targeted molecular applicable formalin-fixed paraffin-embedded (FFPE) endomyocardial biopsies (EMB) can be easily implemented in clinical practice. We aimed develop validate first rejection diagnostic system dedicated heart transplantation (HTx). Methods An international multicenter study was designed, building a deep phenotyped...