A5028555797- Transplantation: Methods and Outcomes
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Tissue Engineering and Regenerative Medicine
- Cardiac Structural Anomalies and Repair
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Cardiac Valve Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Renin-Angiotensin System Studies
- Cardiac Arrest and Resuscitation
- Atherosclerosis and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Aortic aneurysm repair treatments
- Colorectal and Anal Carcinomas
- Mesenchymal stem cell research
- Cell Adhesion Molecules Research
- IL-33, ST2, and ILC Pathways
- Renal and related cancers
- Hormonal Regulation and Hypertension
- T-cell and B-cell Immunology
- Cardiac Ischemia and Reperfusion
Hôpital Européen
2016-2025
Hôpital Européen Georges-Pompidou
2016-2025
Inserm
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Université Paris Cité
2015-2024
Centre Hospitalier de Luxembourg
2024
Paris Cardiovascular Research Center
2014-2023
Sorbonne Université
2005-2022
Hôpital Cochin
1988-2022
Hôpital Armand-Trousseau
2022
The role of the adaptive immune response in controlling growth and recurrence human tumors has been controversial. We characterized tumor-infiltrating cells large cohorts colorectal cancers by gene expression profiling situ immunohistochemical staining. Collectively, immunological data (the type, density, location within tumor samples) were found to be a better predictor patient survival than histopathological methods currently used stage cancer. results validated two additional populations....
The role of tumor-infiltrating immune cells in the early metastatic invasion colorectal cancer is unknown.
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic T cells and different subsets helper in human colorectal cancers correlated their impact on disease-free survival. A panel related genes were 125 frozen specimens. Infiltrating cells, Treg, Th1, Th17 also quantified center invasive margin tumors. By hierarchical clustering correlation matrix identified functional clusters associated...
Purpose The prognosis of patients with colorectal cancer has sometimes proved uncertain; thus, the prognostic significance immune criteria was compared that tumor extension using American Joint Committee on Cancer/International Union Against Cancer–TNM (AJCC/UICC-TNM) staging system. Patients and Methods We studied intratumoral infiltrates in center invasive margin 599 specimens stage I to IV cancers from two independent cohorts. analyzed these findings relation degree frequency recurrence....
Many patients who present with early-stage colorectal cancer (International Union Against Cancer TNM stages I and II) are nevertheless at high risk of relapse. We hypothesized that intratumoral immune reaction could influence their prognosis.The was investigated in 29 tumors by large-scale real-time polymerase chain reaction. Cytotoxic (CD8) memory (CD45RO) T cells were quantified immunohistochemical analyses tissue microarrays from the center (CT) invasive margin (IM) 602 two independent...
Head and neck cancers positive for human papillomavirus (HPV) have a more favorable clinical outcome than HPV-negative cancers, but it is unknown why this the case. We hypothesized that prognosis was affected by intrinsic features of HPV-infected tumor cells or differences in host immune response. In study, we focused on comparison regulatory Foxp3(+) T programmed death-1 (PD-1)(+) microenvironment tumors were negative HPV, two groups matched various biologic parameters. HPV-positive head...
Abstract Purpose: CD4+ T cells play a central role in initiating and maintaining anticancer immune responses. However, regulatory CD4+CD25+ which express Foxp3 have also been shown to inhibit antitumor effector cells. In view of these heterogeneous T-cell populations, this study was designed determine the prognostic value various tumor-infiltrating populations head neck squamous cell carcinoma. Experimental Design: Eighty-four newly diagnosed untreated patients with histologically proven...
Erythropoietin (Epo)-producing cells were identified in the murine hypoxic kidney by situ hybridization. Profound anemia was induced order to greatly increase Epo production. This resulted high levels of mRNA kidney. 35S-labeled DNA fragments gene used as probes for Control experiments conducted parallel included kidneys nonanemic mice, RNase-treated sections, and non-Epo-related DNA. The probe gave a specific hybridization signal cortex lesser extent outer medulla. Glomerular tubular not...
To determine whether the tumor immune infiltrate, as recently evaluated with Immunoscore methodology, could be a useful prognostic marker in patients rectal cancers.The influence of infiltrate on patient's outcome was investigated or without preoperative chemoradiation therapy (pCRT). The density total (CD3(+)) and cytotoxic (CD8(+)) T lymphocytes by immunohistochemistry quantified dedicated image analysis software surgical specimens cancer (n = 111) who did not receive pCRT biopsies...
Cell therapy holds promise for tissue regeneration, including in individuals with advanced heart failure. However, treatment of disease bone marrow cells and skeletal muscle progenitors has had only marginal positive benefits clinical trials, perhaps because adult stem have limited plasticity. The identification, among human pluripotent cells, early cardiovascular cell required the development first cardiac lineage would shed light on cardiogenesis might pave way degenerative diseases. Here,...