A5013984891- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Sepsis Diagnosis and Treatment
- Virus-based gene therapy research
- Adipokines, Inflammation, and Metabolic Diseases
- Escherichia coli research studies
- Cancer Research and Treatments
- Multiple Myeloma Research and Treatments
- Viral gastroenteritis research and epidemiology
- Analytical Methods in Pharmaceuticals
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Ferroptosis and cancer prognosis
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
Ho Chi Minh City International University
2025
Vietnam National University Ho Chi Minh City
2025
Paris Cardiovascular Research Center
2012-2024
Inserm
2015-2024
Université Paris Cité
2015-2024
Hôpital Européen Georges-Pompidou
2012-2024
Medical Genetics Center
2024
University of Virginia
2024
Assistance Publique – Hôpitaux de Paris
2012-2024
Agricultural Genetics Institute
2023
Head and neck cancers positive for human papillomavirus (HPV) have a more favorable clinical outcome than HPV-negative cancers, but it is unknown why this the case. We hypothesized that prognosis was affected by intrinsic features of HPV-infected tumor cells or differences in host immune response. In study, we focused on comparison regulatory Foxp3(+) T programmed death-1 (PD-1)(+) microenvironment tumors were negative HPV, two groups matched various biologic parameters. HPV-positive head...
Abstract Tissue-resident memory T cells (Trm) represent a new subset of long-lived that remain in tissue and do not recirculate. Although they are considered as early immune effectors infectious diseases, their role cancer immunosurveillance remains unknown. In preclinical model head neck cancer, we show intranasal vaccination with mucosal vector, the B subunit Shiga toxin, induces local Trm inhibits tumour growth. As recirculate, demonstrate crucial efficacy vaccine parabiosis experiments....
Mucosal vaccination induces targeted CD8 + T cell homing to inhibit mucosal tumors.
To determine the effect of dexamethasone on antimyeloma effects lenalidomide, we tested in vitro proliferation, tumor suppressor gene expression, caspase activity, cell cycling, and apoptosis levels a series multiple myeloma (MM) plasma leukemia lines treated with lenalidomide dexamethasone, alone or combination. The immunomodulatory activities such as T natural killer (NK) activation was measured via interleukin [IL]-2 production, interferon-γ granzyme B production respectively....
Abstract Aims The cardioprotective effects of human induced pluripotent stem cell-derived cardiovascular progenitor cells (CPC) are largely mediated by the paracrine release extracellular vesicles (EV). We aimed to assess immunological behaviour EV-CPC, which is a prerequisite for their clinical translation. Methods and results Flow cytometry demonstrated that EV-CPC expressed very low levels immune relevant molecules including HLA Class I, CD80, CD274 (PD-L1), CD275 (ICOS-L); moderate...
Background Resident memory T lymphocytes (T RM ) are located in tissues and play an important role immunosurveillance against tumors. The presence of prior to treatment or their induction is associated the response anti-Programmed cell death protein 1 (PD-1)/Programmed death-ligand (PD-L1) immunotherapy efficacy cancer vaccines. Previous work by our group others has shown that intranasal route vaccination allows more efficient these cells head neck lung mucosa, resulting better tumor...
There is growing interest in the association of radiotherapy and immunotherapy for treatment solid tumors. Here, we report an extremely effective combination local irradiation (IR) Shiga Toxin B (STxB)-based human papillomavirus (HPV) vaccination HPV-associated head neck squamous cell carcinoma (HNSCC). The efficacy vaccine was tested using a model HNSCC obtained by grafting TC-1/luciferase cells at submucosal site inner lip immunocompetent mice. Irradiation STxB-E7 acted synergistically...
High-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive histological subtype of often presents with metastatic disease. The drivers metastasis in HGSOC remain enigmatic. APOBEC3A (A3A), an enzyme that generates mutations across various cancers, has been proposed as a mediator tumor heterogeneity disease progression. However, role A3A not explored. We observed association between high levels APOBEC3-mediated mutagenesis poor overall survival primary HGSOC. experimentally...
Tolerance induction by dendritic cells (DCs) is, in part, mediated the activation of regulatory T (Tregs). We have previously shown vitro that human DCs treated with glucocorticoids (GCs), IL-10, or TGF-β upregulate GC-Induced Leucine Zipper protein (GILZ). GILZ overexpression promotes DC differentiation into generate IL-10-producing Ag-specific Tregs. To investigate whether these observations extend vivo, we generated CD11c-GILZ(hi) transgenic mice. from mice constitutively overexpress to...
Spontaneous regression of metastatic melanoma is an exceedingly rare event, with only 76 well-documented cases in the literature since 1866. Here, we present case a patient who developed despite interferon therapy and then achieved spontaneous shortly after reaction to tetanus–diphtheria–pertussis vaccination. A common theme among these development febrile illness before remission malignant disease. brief overview proposed mechanisms for miraculous recoveries presented, including highlight...
Studies support the beneficial effects of glucocorticoids (GCs) during septic shock, steering research toward potential role GC-induced proteins in controlling excessive inflammatory responses. GILZ is a glucocorticoid-induced protein involved anti-inflammatory GCs. We investigated whether overexpression specifically limited to monocytes and macrophages (M/M) alone could control inflammation, thus improving outcome shock animal models. also monitored expression M/M from mice septic-shock...
Abstract Type I IFNs are needed for the production of antiviral antibodies in mice; whether they also stimulate primary antibody responses vivo during human viral infections is unknown. This was assessed patients acutely infected with HIV-1 and treated IFN-α2b. Patients acute infection were randomized to receive antiretroviral therapy alone (Group A, n=60) or combined 14 weeks pegylated-IFN-α2b B, n=30). Emergence anti-HIV monitored 32 by Western blot (WB) analyses serum samples. IFN-α2b...
The efficacy of an antitumoral vaccine relies both on the choice antigen targeted and its design. tumor survivin is attractive target to develop therapeutic cancer vaccines because restricted over-expression vital functions in most human tumors. Accordingly, several clinical trials targeting various indications have been conducted. Most them relied short peptide-based showed promising, but limited results. In this study, we investigated immunogenicity a new long synthetic peptide (LSP)-based...