A5082813733- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Parasitic infections in humans and animals
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Parasitic Infections and Diagnostics
- Chemokine receptors and signaling
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Sepsis Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Mast cells and histamine
- Congenital Anomalies and Fetal Surgery
- HIV Research and Treatment
- Amoebic Infections and Treatments
- Antifungal resistance and susceptibility
- COVID-19 Clinical Research Studies
- Hidradenitis Suppurativa and Treatments
- Immune Response and Inflammation
- Pneumocystis jirovecii pneumonia detection and treatment
- Thermal Regulation in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Allergic Rhinitis and Sensitization
- Parasites and Host Interactions
- Liver Disease Diagnosis and Treatment
Inserm
2012-2024
Institut de Recherche Vaccinale
2014-2024
Institut Mondor de Recherche Biomédicale
2021-2024
Université Paris-Est Créteil
2006-2024
Inflammation, Microbiome and Immunosurveillance
2012-2015
Université Paris-Saclay
2015
Université Paris-Sud
2003-2014
Université Paris Cité
2013
Hôpital Antoine-Béclère
2005-2006
Assistance Publique – Hôpitaux de Paris
2006
Pulmonary hypertension is characterised by a progressive increase in pulmonary arterial resistance due to endothelial and smooth muscle cell proliferation resulting chronic obstruction of small arteries. There evidence that inflammatory mechanisms may contribute the pathogenesis human experimental hypertension. The aim study was address role fractalkine (CX3CL1) responses vascular remodelling monocrotaline-induced model. expression CX3CL1 its receptor CX3CR1 studied means...
Abstract Reactivation of latent Mycobacterium tuberculosis ( Mtb ) infection is a major complication anti-tumour necrosis factor (TNF)-α treatment, but its mechanism not fully understood. We evaluated the effect TNF antagonists infliximab (Ifx), adalimumab (Ada) and etanercept (Eta) on anti-mycobacterial immune responses in two conditions: with ex vivo studies from patients treated vitro addition to cells stimulated mycobacterial antigens. In both cases, we analysed response CD4 + T...
Abstract Chemerin is a potent chemotactic factor that was identified recently as the ligand of ChemR23, G protein-coupled receptor expressed by mononuclear phagocytes, dendritic cells (DCs), and NK cells. synthesized secreted precursor, prochemerin, which poorly active on ChemR23. However, prochemerin can be converted rapidly into full ChemR23 agonist proteolytic removal carboxy-terminal peptide. This maturation step mediated neutrophil-derived serine proteases elastase cathepsin G. In...
Abstract Background Biomarkers of disease severity might help individualizing the management patients with acute respiratory distress syndrome (ARDS). Whether alveolar compartmentalization biomarkers has a clinical significance in pneumonia-related ARDS is unknown. This study aimed at assessing interrelation ARDS/sepsis and blood compartments explored their association outcomes. Methods Immunocompetent admitted between 2014 2018 were included prospective monocentric study. Bronchoalveolar...
Nipah virus (NiV) has been recently ranked by the World Health Organization as being among top eight emerging pathogens likely to cause major epidemics, whereas no therapeutics or vaccines have yet approved. We report a method deliver immunogenic epitopes from NiV through targeting of CD40 receptor antigen-presenting cells fusing selected humanized anti-CD40 monoclonal antibody glycoprotein with conserved fusion and nucleocapsid peptides. In African green monkey model, CD40.NiV induces...
Abstract Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children pregnant women. Here, we present a new generation of subunit targeting antigens CD40-expressing antigen-presenting cells. We demonstrate that the receptor-binding domain (RBD) spike protein CD40 (αCD40.RBD) induces significant...
SUMMARY Differences have been shown between HLA characteristics of patients with different courses alveolar echinococcosis (AE). Notably the B8, DR3, DQ2 haplotype was associated more severe forms this granulomatous parasitic disease. We compared IL-10, IL-5, interferon-gamma (IFN-γ) and tumour necrosis factor (TNF) secretion by peripheral blood mononuclear cells (PBMC) isolated from eight HLA-DR3+, DQ2+, B8+ AE 10 HLA-DR3−, DQ2−, B8− after non-specific mitogenic specific Echinococcus...
Mauritania lies between West-Central Africa where human cystic echinococcosis (CE) is considered extremely rare and West Maghreb CE accounts for a real public health problem. Until 1992, was as CE-free even though seemed well known in livestock. In the introduction of ultrasonography led to diagnosis first cases. 1997, veterinary study revealed that dogs living around Nouakchott were commonly infected by Echinococcus granulosus. To assess E. granulosus transmission identify most relevant...
Tolerance induction by dendritic cells (DCs) is, in part, mediated the activation of regulatory T (Tregs). We have previously shown vitro that human DCs treated with glucocorticoids (GCs), IL-10, or TGF-β upregulate GC-Induced Leucine Zipper protein (GILZ). GILZ overexpression promotes DC differentiation into generate IL-10-producing Ag-specific Tregs. To investigate whether these observations extend vivo, we generated CD11c-GILZ(hi) transgenic mice. from mice constitutively overexpress to...
There is an urgent need of a new generation vaccine that are able to enhance protection against SARS-CoV-2 and related variants concern (VOC) emerging coronaviruses.We identified conserved T- B-cell epitopes from Spike (S) Nucleocapsid (N) highly homologous 38 sarbecoviruses, including VOCs, design protein subunit targeting antigens Dendritic Cells (DC) via CD40 surface receptor (CD40.CoV2).CD40.CoV2 immunization elicited high levels cross-neutralizing antibodies SARS-CoV-2, SARS-CoV-1 in...
SUMMARY To clarify the role of Th1- and Th2-type cytokines in various outcomes human alveolar echinococcosis (AE), cytokine immune response self-cured patients was studied compared with those progressive AE healthy subjects. Self-cured were divided into two groups according to following clinical features: subjects who had positive Echinococcus multilocularis serologies hepatic calcifications typical classified as ‘abortive AE’ patients, E. but no lesions or detectable by ultrasonography...
Glucocorticoids (GCs) decrease tissue mast cell (MC) number and prevent their activation via high-affinity IgE receptor. Glucocorticoid-induced leucine zipper (GILZ) is one of the GC-induced genes, which inhibits functions transcriptional activators AP-1 NF-kappaB. GILZ appears to be a critical actor in anti-inflammatory immunosuppressive effects GCs human T lymphocytes, macrophages dendritic cells.We investigated whether was produced by MCs synthesis stimulated GCs. We also production...
Objectives: The ANRS-112 INTERPRIM trial assessed whether fixed-cycles of antiretroviral treatment interruption (ART-STI) combined or not with pegylated interferon alpha-2b (peg-IFN) could lower viral load and achieve a healthier immune system in patients diagnosed during primary HIV-1-infection (PHI). Design methods: Patients were randomized to receive either continuous ART (cART) 72 weeks, cART 36 weeks followed by three ART-STIs, the same ART-STIs associated peg-IFN first 14 each...
Studies support the beneficial effects of glucocorticoids (GCs) during septic shock, steering research toward potential role GC-induced proteins in controlling excessive inflammatory responses. GILZ is a glucocorticoid-induced protein involved anti-inflammatory GCs. We investigated whether overexpression specifically limited to monocytes and macrophages (M/M) alone could control inflammation, thus improving outcome shock animal models. also monitored expression M/M from mice septic-shock...
The development of HIV-1 vaccines is challenged by the lack relevant models to accurately induce human B- and T-cell responses in lymphoid organs. In humanized mice reconstituted with hematopoietic stem cells (hu-mice), B cell-development function are impaired fail efficiently transition from IgM IgG cells. Here, we found that CD40-targeted vaccination combined CpG-B adjuvant overcomes usual defect B-cell switch maturation hu-mice. We further dissected hu-B cell directed against Env protein...