Dominique Salmon
A5053580384- Hepatitis C virus research
- HIV Research and Treatment
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Healthcare Systems and Practices
- Mycobacterium research and diagnosis
- Viral-associated cancers and disorders
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- Diagnosis and treatment of tuberculosis
- Orthopedic Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Pneumonia and Respiratory Infections
- Peripheral Neuropathies and Disorders
- Blood groups and transfusion
- Antibiotics Pharmacokinetics and Efficacy
- Systemic Lupus Erythematosus Research
- Antimicrobial Resistance in Staphylococcus
Assistance Publique – Hôpitaux de Paris
2016-2025
Institut Alfred Fournier
2023-2025
Hôpital Cochin
2016-2025
Hôtel-Dieu de Paris
2012-2024
Université Paris Cité
2015-2024
Délégation Paris 5
2011-2024
Hotel Dieu Hospital
2020-2023
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2009-2023
Inserm
1973-2022
Hôpital Bichat-Claude-Bernard
1988-2022
Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). The universal presence HHV-8 in early KS has not yet been shown. We used a mAb (LN53) against latent nuclear antigen-1 (LNA-1) encoded by ORF73 study distribution cell types latently infected patch, plaque, nodular KS, MCD, PEL. In present <10% cells forming walls ectatic vessels. surrounding slit-like...
Abstract Objective Tuberculosis (TB) is associated with anti–tumor necrosis factor (anti‐TNF) monoclonal antibody (mAb) therapy, but whether this association drug‐specific remains a concern. Our objective was to describe cases of TB anti‐TNF mAb identify risk factors, and estimate the incidence. Methods We conducted an incidence study case–control analysis investigate newly diagnosed use agents. As part French Research Axed on Tolerance Biotherapies (RATIO) registry, for 3 years we collected...
Whereas recent investigations have revealed viral, inflammatory, and vascular factors involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung pathogenesis, the pathophysiology of neurological disorders disease 2019 (COVID-19) remains poorly understood. Olfactory taste dysfunction are common COVID-19, especially mildly symptomatic patients. Here, we conducted a virologic, molecular, cellular study olfactory neuroepithelium seven patients with COVID-19 presenting loss...
The multicenter national Mortalité 2005 survey aimed at describing the distribution of causes death among HIV-infected adults in France and its changes as compared with 2000.Physicians involved management HIV infection notified deaths documented using a standardized questionnaire similar to previous performed 2000.Overall, 1042 were (vs 964 2000): median age, 46 years 41 years); men, 76%; last CD4 cell count, 161/mm 94). proportion underlying due AIDS decreased (36% vs 47% 2000), cancer not...
The Mortalité 2010 survey aimed at describing the causes of death among HIV-infected patients in France and their evolution since 2000.A national sample clinical sites, providing HIV care treatment, notified documented deaths using a standardized questionnaire.The 90 participating wards 728 deaths. Median age was 50 years (interquartile range 45-58) 75% were men. main underlying AIDS-related (25% vs. 36% 2005 47% 2000), non-AIDS non-viral hepatitis-related malignancy (22 17 11%),...
Abstract BACKGROUND Before the introduction of highly active antiretroviral therapy (HAART), malignancies accounted for less than 10% all deaths among human immunodeficiency virus (HIV)‐infected patients. This figure may have increased, and observed types malignant disease been modified, as a result decreased occurrence opportunistic infections, chronicity HIV infection, possible oncogenic role itself, aging HIV‐infected population. METHODS All French hospital wards involved in management...
Objective: To describe cases of lymphoma associated with anti-TNF therapy, identify risk factors, estimate the incidence and compare risks for different agents. Methods: A national prospective registry was designed (Research Axed on Tolerance bIOtherapies; RATIO) to collect all in French patients receiving therapy from 2004 2006, whatever indication. case–control analysis conducted including two controls treated per case an study population used as reference. Results: 38 lymphoma, 31...
The goal of the current study was to describe distribution and characteristics malignancy related deaths among human immunodeficiency virus (HIV)-infected patients with use data obtained from a national survey conducted in France 2005 compare results similar 2000.The underlying cause death documented using standardized questionnaire fulfilled French hospital wards networks that were involved treatment HIV-infected patients.Among 1042 reported (964 2000), 344 cancer (34%), which represented...
Background. Few studies consider the incidence of individual AIDS-defining illnesses (ADIs) at higher CD4 counts, relevant on a population level for monitoring and resource allocation.
Abstract Background Therapeutic control of HIV replication reduces the size viral reservoir, particularly among central memory CD4+ T cells, and this effect might be accentuated by early treatment. Methods We examined ART initiated at time primary infection (early ART), lasting 2 6 years in 11 10 patients, respectively, on reservoir peripheral resting sorted into naive (TN), (TCM), transitional (TTM) effector (TEM) comparison with post-treatment controllers (PTCs). Results Between baseline...
ABSTRACT The ex vivo antiviral CD8 + repertoires of 34 human immunodeficiency virus (HIV)-seropositive patients with various CD4 T-cell counts and loads were analyzed by gamma interferon enzyme-linked immunospot assay, using peptides derived from HIV type 1 Epstein-Barr (EBV). Most recognized many peptides, markedly high frequencies, in association all the HLA class I molecules tested. We found no correlation between intensity anti-HIV responses or load. In contrast, polyclonality was...
To determine the correlates of immune recovery from active human CMV (HCMV) disease, we compared antigenic repertoire, diversity, magnitude, and differentiation HCMV-specific CD8+ T cells in HIV-HCMV coinfected subjects with no, cured, or HCMV disease healthy HIV-negative HCMV-positive controls. ELISPOT–IFN-γ assays using peptide pools spanning pp65 immediate early 1 (IE1) proteins showed that had a significantly broader repertoire greater diversity HIV-positive patients controlling...
Abstract Reactivation of latent Mycobacterium tuberculosis ( Mtb ) infection is a major complication anti-tumour necrosis factor (TNF)-α treatment, but its mechanism not fully understood. We evaluated the effect TNF antagonists infliximab (Ifx), adalimumab (Ada) and etanercept (Eta) on anti-mycobacterial immune responses in two conditions: with ex vivo studies from patients treated vitro addition to cells stimulated mycobacterial antigens. In both cases, we analysed response CD4 + T...