A5008580628- Bone health and treatments
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Urticaria and Related Conditions
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Estrogen and related hormone effects
- Diabetes Treatment and Management
- Parathyroid Disorders and Treatments
- Whipple's Disease and Interleukins
- Inflammasome and immune disorders
- Metabolism, Diabetes, and Cancer
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Vitamin D Research Studies
- Infectious Diseases and Tuberculosis
- Orthopedic Infections and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hormonal and reproductive studies
- Systemic Sclerosis and Related Diseases
- Spine and Intervertebral Disc Pathology
- Autoimmune and Inflammatory Disorders Research
- Heterotopic Ossification and Related Conditions
- Adrenal Hormones and Disorders
Centre Hospitalier Universitaire d'Angers
2015-2024
Nantes Université
2020-2024
Société Française de Rhumatologie
2009-2024
Inserm
2007-2024
Université d'Angers
2014-2023
Oniris
2023
Biomatériaux et Bioingénierie
2009-2021
Université Nantes Angers Le Mans
2012-2016
Ingénierie Moléculaire et Physiopathologie Articulaire
2014-2015
Université de Lorraine
2013-2014
Interleukin-26 (IL-26), a member of the IL-10 cytokine family, induces production proinflammatory cytokines by epithelial cells. IL-26 has been also reported overexpressed in Crohn's disease, suggesting that it may be involved physiopathology chronic inflammatory disorders. Here, we have analyzed expression and role rheumatoid arthritis (RA), disorder characterized joint synovial inflammation. We report concentrations are higher serums RA patients than healthy subjects dramatically elevated...
Objective. To determine the pattern of demyelinating disorders (DDs) occurring during anti-TNF-α therapy. Methods. Between June 2005 and April 2008, 1800 French rheumatologists internists were contacted to report cases DDs in patients treated with anti-TNF-α. Results. After a median 10.2 (1.5–39.9) months treatment, 33 developed DDs: 22 had CNS 11 peripheral nervous system (PNS) involvement. Underlying diseases RA (n = 16), AS 11), PsA 4), JIA 1) PM 1). Anti-TNF-α was infliximab 15),...
Type 1 diabetes mellitus is associated with a high risk for bone fractures. Although mass reduced, quality also dramatically altered in this disorder. However, recent evidences suggest beneficial effect of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP-1) pathways on quality. The aims present study were to conduct comprehensive investigation strength at organ tissue level; ascertain whether enzyme resistant GIP or GLP-1 mimetic could be preventing...
Objective. To describe cases of development pulmonary nodulosis or aseptic granulomatous lung disease in patients with rheumatoid arthritis (RA) receiving anti-tumor necrosis factor-α (TNF-α) therapy. Methods. A call for observation such was sent to members the French “Club Rhumatismes et Inflammation.” The had occur after introduction TNF-α-blocking Results. Eleven were examined: 6 treated etanercept, 2 infliximab, and 3 adalimumab. Pulmonary nodular lesions observed a mean treatment period...
Whipple disease (WD) is a rare infectious systemic disease. Rheumatologists are at the frontline of WD diagnosis due to early rheumatological manifestations. An crucial, as usual anti-rheumatic drugs, especially TNF inhibitors, may worsen course. We conducted retrospective multicentre national study from January 2010 April 2020 better characterize features WD. Classic (CWD) was defined by positive periodic acid-Schiff (PAS) staining small-bowel biopsy sample, and non-CWD (NCWD) negative PAS...
Introduction Hypophosphatasia (HPP) is a rare genetic disease caused by loss-of-function mutations in the ALPL gene encoding tissue non-specific alkaline phosphatase (ALP). Mild HPP usually misdiagnosed adult age. While an elevated serum ALP value draws more attention than low value, should be better recognised and may lead to detection. Methods Patients were selected from records of biochemistry department six University Hospitals France. hospitalised departments rheumatology internal...