A5049469702- Bone health and treatments
- Diabetes Treatment and Management
- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Connective tissue disorders research
- Bone and Dental Protein Studies
- Bone and Joint Diseases
- Geology and Paleoclimatology Research
- Marine and coastal ecosystems
- Parathyroid Disorders and Treatments
- Peptidase Inhibition and Analysis
- Growth Hormone and Insulin-like Growth Factors
- Neuropeptides and Animal Physiology
- Bone fractures and treatments
- Peroxisome Proliferator-Activated Receptors
- Isotope Analysis in Ecology
- Orthopedic Infections and Treatments
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Pancreatic function and diabetes
- Marine Biology and Ecology Research
- Bariatric Surgery and Outcomes
Université d'Angers
2015-2025
Nantes Université
2017-2025
Centre Hospitalier Universitaire d'Angers
2013-2025
Inserm
2006-2025
Oniris
2022-2025
Université Nantes Angers Le Mans
2012-2024
RMeS - Regenerative Medicine and Skeleton
2023
Biomatériaux et Bioingénierie
2011-2021
Institut d'Imagerie Biomédicale
2014
University of Oxford
2008-2012
Extracellular vesicles (EVs) are biological vectors that can modulate the metabolism of target cells by conveying signalling proteins and genomic material. The level EVs in plasma is significantly increased cardiometabolic diseases associated with obesity, suggesting their possible participation development metabolic dysfunction. With regard to poor definition adipocyte-derived EVs, purpose this study was characterise both qualitatively quantitatively subpopulations secreted fat cells....
Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic healthy controls, determine the effect of receptor activator nuclear factor-kappaB ligand (RANKL) its decoy osteoprotegerin (OPG).Peripheral blood monocytes isolated from nine Charcot patients, eight control participants cultured in presence macrophage-colony stimulating factor (M-CSF) alone, M-CSF RANKL, also RANKL excess concentrations OPG. Osteoclast formation was assessed by...
Bone is permanently remodeled by a complex network of local, hormonal, and neuronal factors that affect osteoclast osteoblast biology. Among these factors, role for gastrointestinal hormones has been proposed based on the evidence bone resorption dramatically falls after meal. Glucagon-like peptide-1 (GLP1) one gut hormones, despite several reports suggesting an anabolic effect GLP1, or its stable analogs, mass, little known about effects GLP1/GLP1 receptor strength. In this study, we...
High input of organic carbon and/or slowly renewing bottom waters frequently create periods with low dissolved oxygen concentrations on continental shelves and in coastal areas; such events can have strong impacts benthic ecosystems. Among the meiofauna living these environments, foraminifera are often most tolerant to levels. Indeed, some species able survive complete anoxia for weeks months. One known mechanism this, observed several species, is denitrification. For other a state highly...
Type 1 diabetes mellitus is associated with a high risk for bone fractures. Although mass reduced, quality also dramatically altered in this disorder. However, recent evidences suggest beneficial effect of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP-1) pathways on quality. The aims present study were to conduct comprehensive investigation strength at organ tissue level; ascertain whether enzyme resistant GIP or GLP-1 mimetic could be preventing...
Abstract Obesity is a major public health issue worldwide. Despite various approaches to weight loss, the most effective technique for reducing obesity, as well diabetes and associated diseases, bariatric surgery. Increasingly, young women without children are undergoing surgery, vertical sleeve gastrectomy (VSG) being common procedure nowadays. However, despite several reports suggesting bone loss after VSG, little known about potential additive effects of gestation lactation VSG health....
Background Interleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-γ. IL-32 has the typical properties of pro-inflammatory mediator although its role in rheumatoid arthritis been recently reported effect on osteoclastogenesis process remains unclear. Methodology/Principal Findings In present study, we have shown that was potent modulator vitro, whereby it promoted differentiation osteoclast precursors into TRAcP+ VNR+ multinucleated cells...
Adipocytes specialized in the storage of energy as fat are among most caveolae-enriched cell types. Loss caveolae produces lipodystrophic diabetes humans, which cannot be reversed by endothelial rescue caveolin expression mice, indicating major importance adipocyte caveolae. However, how participate functions is poorly understood. We investigated dynamic conditions lipid store fluctuations and demonstrate reciprocal regulation density droplet storage. identified caveolin-1 a crucial step...
We report systematic transmission electron microscope (TEM) observations of the cellular ultrastructure selected, small rotalid benthic foraminifera. Nine species from different environments (intertidal mudflat, fjord, and basin) were investigated: Ammonia sp., Elphidium oceanense, Haynesina germanica, Bulimina marginata, Globobulimina Nonionellina labradorica, Nonionella Stainforthia fusiformis Buliminella tenuata. All observed specimens fixed just after collection their natural habitats...
Abstract Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence increased glycolysis triggered by insufficient oxygen supply to tissues. Macrophages are able differentiate from monocytes under such acidotic conditions, remain active in order resolve underlying injury. Here we show that, lactic human differentiating into macrophages characterized depolarized mitochondria, transient reduction mitochondrial mass due mitophagy, significant decrease nutrient...
Diabet. Med. 27, 925–932 (2010) Abstract Aims Thiazolidinediones (TZDs) are associated with a higher risk of bone fracture in women compared men. The aim the present study was to investigate whether TZDs could influence osteocyte behaviour and contribute skeletal phenotype observed TZD‐treated patients. Methods murine MLO‐Y4 cell line used as source osteocytes. These cells were cultured for 24 h 0, 10 −8 m , −7 −6 −5 or −4 pioglitazone, rosiglitazone troglitazone presence absence...