A5112070030- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Autoimmune Bullous Skin Diseases
- Gout, Hyperuricemia, Uric Acid
- Peripheral Neuropathies and Disorders
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Health, Medicine and Society
- Psoriasis: Treatment and Pathogenesis
- Musculoskeletal Disorders and Rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 Clinical Research Studies
- Orthopedic Infections and Treatments
- Cytokine Signaling Pathways and Interactions
- Hypertrophic osteoarthropathy and related conditions
- Monoclonal and Polyclonal Antibodies Research
- Healthcare Systems and Practices
- Pregnancy and Medication Impact
- Case Reports on Hematomas
- Ectopic Pregnancy Diagnosis and Management
Centre Hospitalier de Mulhouse
2007-2024
Groupe Hospitalier de la Région de Mulhouse et Sud Alsace
2017-2022
Hôpital Émile-Roux
2010-2015
Institut de Recherche en Hématologie et Transplantation
2013
Immunologie, Immunopathologie et Chimie Thérapeutique
2007
Hôpitaux Universitaires de Strasbourg
2005-2007
Hôpital Civil, Strasbourg
2007
Hôpital d'Hautepierre
2002-2006
Inserm
2006
Université Paris Cité
2006
Gene expression analysis of target organs might help provide new insights into the pathogenesis autoimmune diseases. We used global gene profiling minor salivary glands to identify patterns in patients with primary Sjögren's syndrome (pSS), a common and prototypic systemic disease. allowed for differentiating most pSS from controls. The 23 genes IFN pathways, including two Toll-like receptors (TLR8 TLR9), was significantly different between Furthermore, increased IFN-inducible genes, BAFF...
One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.To compare efficacy a non-TNF-targeted biologic (non-TNF) vs second anti-TNF drug for insufficient TNF inhibitor.A total 300 (conducted between 2009-2012) arthritis, persistent disease activity (disease score in 28 joints-erythrocyte sedimentation rate [DAS28-ESR] ≥ 3.2 [range, 0-9.3]) and an therapy were included...
Non-conventional MHC class I MIC molecules interact not with the TCR, but NKG2D, a C-type lectin activatory receptor present on most NK, gammadelta and CD8(+) alphabeta T cells. While this interaction is critical in triggering/calibrating cytotoxic activity of these cells, actual extent its vivo involvement, man, infection, cancer or autoimmunity, needs further assessment. The latter has gained momentum along reported expansion peripheral CD4(+)CD28(-)NKG2D(+) cells rheumatoid arthritis...
Objective Among the most significant challenges in SLE are excessive diagnosis delay and lack of coordinated care. The aim study was to investigate patient pathways order improve clinical organisational management those with suspected confirmed SLE. Methods We conducted a cross-sectional patients SLE, healthcare providers other representative stakeholders. Focus groups were conducted, based on collected data impactful disruption points identified. A novel framework individual developed,...
The efficacy of antitumour necrosis factor alpha (anti-TNF-α) treatment is well recognised in rheumatoid arthritis (RA) but remains controversial systemic lupus erythematosus (SLE). Therefore, the role anti-TNF-α 'Rhupus', a disease sharing features RA and SLE, still debated.To evaluate tolerance patients with rhupus.Fifteen rhupus Disease Activity Score 28 (DAS 28) >3.2 despite conventional disease-modifying anti-rheumatic drugs were included an open-label study. Patients monitored at...
To describe current management and outcome of native joint septic arthritis (NJSA) in French rheumatology departments.
Introduction : Les patients traités par biothérapie doivent en connaître les complications. L'acquisition de compétences sécurité est l'un des objectifs programmes d'éducation thérapeutique (ETP) dans rhumatismes inflammatoires chroniques (RIC). Objectifs Évaluation l'impact du programme ETP RHIN-RIC sur et d'autosoins sous pour un RIC. Méthodes Appréciation le questionnaire Biosecure 80 intraveineuse RIC hôpital jour Rhumatologie Groupe Hospitalier la région Mulhouse-Sud-Alsace. Résultats...
Background: At a time when vaccines are being prioritized for individuals most at risk, there is currently no clear evidence that risk of SARS-CoV-2 infection higher patients with than without inflammatory arthritides (IA). Biologic use was not associated worse COVID-19 outcomes yet but the case rituximab (RTX) remains an issue, given its immunological long term effect, role humoral response against and indirect effect on T-cell response. A potential association between raised by reports...
<h3>Background</h3> According to the EULAR recommendations for management of patients with rheumatoid arthritis (RA), use a biologic therapy should be done in combination methotrexate (MTX) or another synthetic DMARD (csDMARD). However, "real-life studies", 30% are treated monotherapy. <h3>Objectives</h3> Our objectives were describe characteristics RA receiving intravenous without csDMARD and reasons <h3>Methods</h3> We made an observational, retrospective multicentric study 3 rheumatology...
<h3>Background</h3> We recently reported the clinical efficacy and safety of anti-TNF-alpha in a cohort 15 rhupus patients with rheumatoid arthris systemic lupus (“rhupus”). TNF-alpha type I interferon (IFN) were to be crossregulated gene expression study juvenile idiopathic arthritis. Treating anti-TNF these could raise concern potential overexpression IFN-inducible genes chemokines, which play pathogenic role SLE. <h3>Objectives</h3> To evaluate changes levels chemokines under treatment...
<h3>Background</h3> Calcium pyrophosphate (CPP) associated arthritis is common in elderly patients. Non-steroidal anti-inflammatory drugs (NSAID), colchicine, oral or local steroids are recommended (1), but some patients these therapies non-effective contra-indicated and therapeutic alternatives limited. Recently, the pivotal role of IL-1β crystal-induced inflammation has been demonstrated, inhibitors such as anakinra, shown to be effective treatment acute gout (2). <h3>Objectives</h3> To...