A5041229167- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Bone health and osteoporosis research
- Spondyloarthritis Studies and Treatments
- Hip and Femur Fractures
- Bone fractures and treatments
- Bone health and treatments
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parkinson's Disease and Spinal Disorders
- Hip disorders and treatments
- Infectious Diseases and Tuberculosis
- Sarcoidosis and Beryllium Toxicity Research
- Psoriasis: Treatment and Pathogenesis
- Opioid Use Disorder Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Meta-analysis and systematic reviews
- Healthcare Systems and Practices
- Muscle and Compartmental Disorders
- Dermatological and COVID-19 studies
- Neurological disorders and treatments
- Glycogen Storage Diseases and Myoclonus
- Peripheral Neuropathies and Disorders
- Clinical practice guidelines implementation
Centre Hospitalier Universitaire de Tours
2010-2024
Université de Tours
2007-2024
Société Française de Rhumatologie
2017
Centre National pour la Recherche Scientifique et Technique (CNRST)
2011
Centre National de la Recherche Scientifique
2010
Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and approved for refractory rheumatoid arthritis. We studied the association between infliximab concentration long-term control of disease activity in patients with arthritis treated on routine basis both cross-sectional analysis over long term. Trough serum concentrations were measured receiving infusions during period August October 2006. Disease was assessed by Activity Score 28 Joints (DAS28)...
Introduction Hypophosphatasia (HPP) is a rare genetic disease caused by loss-of-function mutations in the ALPL gene encoding tissue non-specific alkaline phosphatase (ALP). Mild HPP usually misdiagnosed adult age. While an elevated serum ALP value draws more attention than low value, should be better recognised and may lead to detection. Methods Patients were selected from records of biochemistry department six University Hospitals France. hospitalised departments rheumatology internal...
Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and which approved for refractory spondyloarthritis (SpA). Individual adjustment of infliximab dosage may help improve the therapeutic response in SpA. We investigated whether knowledge serum concentration modifies physician decision improves control disease activity SpA.Thirty-two patients routinely treated with were included an observational open-label study. On visit 1 (V1), according activity,...
Introduction The occurrence of pachyonychia congenita (PC) and acne inversa (AI) may be related to gene mutations. aim this study is identify the genetic cause in a patient with PC AI, explore possible molecular mechanism their co-occurrence. Methods clinical data proband were collected, genomic DNA unaffected parents extracted. variant sites identified by whole-exome sequencing, then his verified Sanger sequencing. Results A heterozygous KRT17 was found patient, resulting missense amino...
La maladie de McArdle, ou glycogénose type 5 (GSD 5), est une myopathie métabolique rare liée à un déficit en myophosphorylase, transmission autosomique récessive. Nous rapportons l'histoire d'un patient 17 ans qui s'est présenté aux urgences pour lombalgie inflammatoire aiguë, sans contexte traumatique, avec élévation des CPK plus 66 000 UI/L (N < 192 UI/L) et CRP 202 mg/L. Le bilan immunologique était négatif l'IRM rachidienne montrait aspect faveur d'une myofasciite nécrosante touchant...
<h3>Background</h3> Musculoskeletal chronic non-cancer pain (CNCP) has a multidimensional impact. Opioid treatments have key role in their management but expose to risks of serious adverse effects and particular opioid use disorder misuse. There is lack data on this topic France. This work assesses the proportion patients with problematic treatment rheumatology department center University Hospital Tours. <h3>Objectives</h3> <h3>Methods</h3> We carried out prospective monocentric...
<h3>Background</h3> Bone Mineral density (BMD) assessment is a useful tool to evaluate bone fragility and largely recommended in patients at risk of osteoporosis. We have previously reported 250 women aged 50 year-old or more that only $≈ $10% them had BMD after forearm fracture (1). <h3>Objectives</h3> Herein, we evaluated prescription anti-osteoporotic drugs large population database. <h3>Methods</h3> identified all fractures years old the "Centre-Val de Loire, France" area between...
Background: Bone fragility is frequent in patients awaiting orthotopic liver transplantation (OLT) for severe disease, leading to a high prevalence of fractures, particularly vertebral ones. During the year following OLT, there an early decrease bone density and incidence new fractures (VF). Objectives: To determine VF due during after OLT large population patients. Methods: We conducted cohort, prospective, descriptive, monocentric study including all with chronic disease OLT. Patients were...