A5002231168- Synthesis and Biological Evaluation
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Insect and Pesticide Research
- Electron Spin Resonance Studies
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cancer, Hypoxia, and Metabolism
- Toxoplasma gondii Research Studies
- Biochemical and Molecular Research
- Free Radicals and Antioxidants
- Cancer therapeutics and mechanisms
- Vanadium and Halogenation Chemistry
- Inorganic and Organometallic Chemistry
- Radiopharmaceutical Chemistry and Applications
- Genomics, phytochemicals, and oxidative stress
- Chemical Reactions and Mechanisms
- Chemical Reaction Mechanisms
- bioluminescence and chemiluminescence research
- X-ray Diffraction in Crystallography
- Herpesvirus Infections and Treatments
Massachusetts Institute of Technology
2024
Emory University
2024
Harvey Mudd College
2024
Columbia University
2024
Howard Hughes Medical Institute
2024
National Eye Institute
2024
National Institutes of Health
2024
Georgia Institute of Technology
2021-2024
Janelia Research Campus
2024
McGovern Institute for Brain Research
2024
Aim of the Study mTOR inhibitors are showing promising results in management vascular anomalies. Although current controlled trials remain to be completed, many individual experiences being published. We present our series children with complex anomalies treated sirolimus. Patients and Methods A retrospective review 41 patients sirolimus between January 2011 December 2015 was performed: 15% (n = 6) had tumors (4 kaposiform hemangioendotheliomas, 1 PTEN) 85% 35) malformations (13 generalized...
In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel (II) formulas [PdCl2(HL)] and [Pd(L)2] synthesized, crystal structure of [Pd(5-nitrofuryl-3-acroleine thiosemicarbazone)2]·3DMSO was solved by X-ray diffraction methods. Most showed higher in vitro growth inhibition activity Trypanosoma cruzi than standard drug Nifurtimox. most cases, ligand maintained or...
Psychrotrophic yeasts were isolated from Antarctic soils, selected based on their ability to grow in apple juice at low temperatures, and evaluated as potential biocontrol agents for the management of postharvest diseases during cold storage. Among species recovered, an isolate Leucosporidium scottii, designated At17, was identified a good agent blue gray mold two cultivars. The produced soluble volatile antifungal substances that inhibitory pathogens. Siderophore production also...
The syntheses of a new series derivatives 1,2,5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole and quinoxaline di-N-oxide are described. In vitro antitrypanosomal activity these compounds was tested against epimastigote forms Trypanosoma cruzi. For the most effective drugs, IIIe IIIf, 50% inhibitory dose (ID50) determined as well their cytotoxicity mammalian fibroblasts. Electrochemical studies ESR spectroscopy show that highest activities observed associated with facile monoelectronation...
Hypoxic cells are an important target for antitumor therapy because tumors typically characterized by such cells. Virtually all which present as solid masses contain hypoxic cells, while normal generally have adequate supply of oxygen. Accordingly, agents can be made selective virtue high activity under conditions. The initial purpose this work was to determine the influence different groups in position 3. Thus, synthesis some 3-NH-substituted derivatives (2a, 3a, 4a) starting from...
Searching for prospective metal-based drugs the treatment of Chagas disease, a new series ten mixed-ligand oxidovanadium(IV) complexes, [VIVO(L-2H)(NN)], where L is tridentate salicylaldehyde semicarbazone derivative (L1–L5) and NN either 5-amine-1,10-phenanthroline (aminophen) or 5,6-epoxy-5,6-dihydro-1,10-phenanthroline (epoxyphen), were synthesized. The compounds characterized in solid state solution. EPR spectroscopy suggests that ligands act as bidentate through both nitrogen donor...
Abstract The new dioxo(semicarbazone)vanadium( V ) complexes cis ‐VO 2 L, where L = salicylaldehyde semicarbazone (L 1 ), 4‐ n ‐butylsemicarbazone or 4‐(2‐naphthyl)semicarbazone 3 have been synthesized, characterized by H and 13 C NMR FTIR spectroscopy tested for bioactivity as potential insulin‐mimetic agents. All dioxovanadium( exhibited essentially no in vitro activity, but the VO complex developed activity presence of ascorbic acid, similar to that vanadyl sulfate. molecular structure...