A5046006941- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Cholinesterase and Neurodegenerative Diseases
- Inflammatory mediators and NSAID effects
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Eicosanoids and Hypertension Pharmacology
- Plant biochemistry and biosynthesis
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Peroxisome Proliferator-Activated Receptors
- Mosquito-borne diseases and control
- Phosphodiesterase function and regulation
- Estrogen and related hormone effects
- Microbial Natural Products and Biosynthesis
- Phenothiazines and Benzothiazines Synthesis and Activities
- NF-κB Signaling Pathways
- Crystal structures of chemical compounds
Universidade Federal do Rio de Janeiro
2016-2025
Laboratório Nacional de Computação Científica
2020
Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular
2016
Rotary International
2010
Fundação Oswaldo Cruz
2007
University of Illinois Chicago
2005-2006
Among a small series of tested N-acylhydrazones (NAHs), the compound 8a was selected as selective submicromolar phosphodiesterase-4 (PDE4) inhibitor associated with anti-TNF-α properties measured both in vitro and vivo. The recognition pattern elucidated through molecular modeling studies based on knowledge 3D-structure zardaverine, PDE4 resembling structure 8a, cocrystallized PDE4. Based further conformational analysis dealing N-methyl-NAHs, quinazoline derivative (19) designed...
The design, synthesis and anti HIV-1 replication inhibition of 3-(cyclopropylethynyl)-3-hydroxy-indolin-2-ones, analogues efavirenz (Sustivatrade mark), are described. Different substituted isatins were used to generate final products that contain pharmacophoric features for RT inhibition, such as the oxoindole cyclopropylethynyl groups. suitability indolin-2-one ring in planned compounds replacement benzoxazinone was proven, since compound 15 presented a greater activity than against not...
Tuberculosis (TB) is the leading cause of death among infectious diseases, and new studies focusing anti‐TB drugs are urgent due to emergence drug‐resistant strains. In this regard, homoisoflavones, an underexplored subgroup flavonoids, were explored for their potential as agents. A series 42 derivatives was synthesized, assessed ability inhibit growth Mycobacterium tuberculosis (Mtb). Derivatives 19, 22, 41 showed good selectivity index potent inhibition Mtb H37Rv (MIC90 2.2, 3.8, 1.9 µM,...
In this paper, we evaluated the antiviral activity against HMPV replication of crude extract marine algae Stypopodium zonale and two meroditerpenoids obtained from it, atomaric acid epitaondiol, a methyl ester derivative acid. Their selectivity indexes were 20.78, >56.81, 49.26 12.82, respectively. Compared to ribavirin, substances showed relatively low cytotoxicity on LLC-MK2 cells, with significant activity, inhibiting at least 90% viral in vitro, which demonstrates potential these natural...
In eukaryotes, protein kinases catalyze the transfer of a gamma-phosphate from ATP (or GTP) to specific amino acids in targets. plants, have been shown participate signaling cascades driving responses environmental stimuli and developmental processes. Plant meristems are undifferentiated tissues that provide major source cells will form organs throughout development. However, non-dividing specialized can also dedifferentiate re-initiate cell division if exposed appropriate conditions. Mps1...
Diabetes is a metabolic disorder characterized by hyperglycemia. When not properly controlled, complications include neuropathy, coronary artery disease, and renal failure. Several drugs are approved for diabetes treatment; however their use associated with side effects lack of efficacy in attenuating the development long-term complications. This work describes virtual screening synthesis novel series sulfonylhydrazone derivatives designed as peroxisome proliferator-activated receptor gamma...