A5040070958- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Phytochemistry and biological activity of medicinal plants
- Alzheimer's disease research and treatments
- Plant biochemistry and biosynthesis
- Synthesis and biological activity
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Chemical synthesis and alkaloids
- Medicinal Plants and Neuroprotection
- Synthesis and Biological Evaluation
- Cannabis and Cannabinoid Research
- Natural Compound Pharmacology Studies
- Biological and pharmacological studies of plants
- Insect Pest Control Strategies
- X-ray Diffraction in Crystallography
- Ethnobotanical and Medicinal Plants Studies
- Crystallization and Solubility Studies
- Enzyme Catalysis and Immobilization
- Curcumin's Biomedical Applications
- Plant-Derived Bioactive Compounds
- Ginkgo biloba and Cashew Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical compounds biological activities
- Pain Mechanisms and Treatments
Universidade Federal de Alfenas
2016-2025
Institute of Chemistry
2025
National Council for Scientific and Technological Development
2023
Universidade Federal do Rio de Janeiro
2004-2020
Universidade de São Paulo
2014
Anahuac Mayab University
2014
Universidade Federal de Minas Gerais
2014
GlaxoSmithKline (United Kingdom)
2014
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
Federico II University Hospital
2014
CHEMICAL CONTROL OF INSECTS.Many substances from different sources have been used by men for decades to control insects.After the 2 nd World War, use of inorganic compounds declined drastically and natural products, as well synthetic derivatives, widely instead.The search alternatives improved development bench top bioassays an array approaches known novel products that shows relevant activities feeding supressors deterrents.The studies concerning mode action environmental impact these...
THE MODERN MEDICINAL CHEMISTRY.Natural products have been utilized by humans since ancient times and the relief cure of their diseases was first purpose for using natural in medicine.The history oriental occidental civilizations is very rich examples utilization medicine health care.Chinese traditional one most important how can be efficient treatment diseases, it points to importance scientific research on products, concerning discovery new active chemical entities.The complexity, diversity...
Alzheimer's disease (AD) is a complex neurodegenerative disorder with multi-faceted pathogenesis. So far, the therapeutic paradigm "one-compound-one-target" has failed and despite enormous efforts to elucidate pathophysiology of AD, still incurable. The multiple factors involved in AD include amyloid aggregation form insoluble neurotoxic plaques Aβ, hyperphosphorylation tau protein, oxidative stress, calcium imbalance, mitochondrial dysfunction deterioration synaptic transmission. These...
The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (−)-3-O-acetylspectaline (1), (−)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (−)-spectaline (4). green fruits this plant were also investigated, resulting in isolation 1 4. Their structures elucidated using a combination multidimensional NMR MS techniques, relative stereochemistries established by NOESY correlations analysis coupling constants. DNA-damaging activity these compounds was...
A new glycosylated biflavonone, morelloflavone-4′″-O-β-d-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) morelloflavone-7″-O-β-d-glycosyl (fukugeside) were isolated from epicarp of Garcinia brasiliensis collected in Brazil. The structures these established using 1H 13C NMR, COSY, gHMQC gHMBC spectroscopy. exhibited antioxidant activity. greatest potency was displayed by (2), with IC50 = 49.5 mM against DPPH absorbance 0.583 at 400 μg/mL for...
Natural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates medicinal chemistry remains undisputed, even after growth combinatorial era. Tropical environments, such Brazilian biomes, offer particularly potential biologically active compounds with unique structures continue contribute toward modern drug discovery. Our bioprospecting plant species Cerrado Atlantic Forest biomes...
Melanoma is considered the most aggressive form of skin cancer, showing high metastatic potential and persistent mortality rates despite introduction immunotherapy targeted therapies. Thus, it important to identify new drug candidates for melanoma. The design hybrid molecules, with different pharmacophore fragments combined in same scaffold, an interesting strategy obtaining multi-target more effective anticancer drugs. We designed nine compounds bearing piperine chlorogenic acid...
THE Cassia GENUS.Species of are widely distributed in tropical and subtropical regions throughout the world, have been extensively investigated chemically pharmacologically.They known to be a rich source phenolic derivatives, most them with important biological pharmacological properties.Some Asian, African Indian tribes use these species as laxative, purgative, antimicrobial, antipyretic, antiviral anti-inflammatory agent.Among number other classes secondary metabolites, such anthracene...