A5008752634- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Insect Pest Control Strategies
- Parasite Biology and Host Interactions
- Synthesis and Biological Evaluation
- Helminth infection and control
- Adenosine and Purinergic Signaling
- Natural Compound Pharmacology Studies
- Leptospirosis research and findings
- Biochemical and Molecular Research
- Phytochemical compounds biological activities
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Toxin Mechanisms and Immunotoxins
- Phytochemistry Medicinal Plant Applications
- Toxoplasma gondii Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Amoebic Infections and Treatments
- Phytochemicals and Antioxidant Activities
- Dermatological diseases and infestations
- Vector-borne infectious diseases
- Free Radicals and Antioxidants
Universidade Federal de Alfenas
2016-2025
Institute of Biomedical Science
2019-2025
Universidade Nova de Lisboa
2024
National School of Public Health
2024
Universidade Federal de Juiz de Fora
2006-2020
Universitario Francisco de Asís
2020
Hospital da Restauração
2018
Universidade de Pernambuco
2018
Universidade Federal de Minas Gerais
2001-2011
Universidade Federal do Rio de Janeiro
2003
Background Various factors contribute to the urbanization of visceral leishmaniasis (VL), including difficulties implementing control measures relating domestic reservoir. The aim this study was determine prevalence canine in an urban endemic area Brazil and associated with Leishmania infantum infection among seronegative PCR-positive dogs. Methodology A cross-sectional conducted Belo Horizonte, Minas Gerais, Brazil. Blood samples were collected from 1,443 Serology carried out by using two...
Infections by protozoans of the genus Leishmania are major worldwide health problem, with high endemicity in developing countries. The drugs choice for treatment leishmaniasis pentavalent antimonials, which exert renal and cardiac toxicity. Thus, there is a strong need safer more effective treatments against leishmaniasis. present study was designated to evaluate, bioguided assay, leishmanicidal activity extracts (hexane, ethyl-acetate ethanolic) molecules both obtained means extraction from...
Polymerase chain reaction (PCR) and its variations represent highly sensitive specific methods for Leishmania DNA detection subsequent canine visceral leishmaniasis (CVL) diagnosis. The aim of this work was to compare three different molecular diagnosis techniques (conventional PCR [cPCR], seminested [snPCR], quantitative [qPCR]) in samples skin spleen from 60 seropositive dogs by immunofluorescence antibody test enzyme-linked immunosorbent assay. Parasitological analysis conducted culture...
Abstract Background Leishmaniasis is endemic in 88 countries the world, and 350 million individuals are at risk of acquiring disease. Treatment for American cutaneous leishmaniasis (ACL) long, expensive, associated with important side‐effects. Methods In this double‐blind, placebo‐controlled study, we treated 102 patients ACL using either a combination single‐strain Leishmania amazonensis killed promastigote vaccine plus half dose meglumine antimoniate, or placebo same regimen 10‐day series...
In the last decade, search for new vaccines against canine visceral leishmaniasis has intensified. However, pattern related to immune protection during long periods after experimental infection in vaccine trials is still not fully understood. Herein, we investigated immunogenicity and parasitological levels intradermal challenge with Leishmania infantum plus salivary gland extract dogs immunized a composed of L. braziliensis antigens saponin as an adjuvant (LBSap vaccine). The LBSap elicited...
The camu-camu seeds, which comprehend about 20% of the fruit weight, is discarded without taking benefit their chemical components and potential application by industry. In current study, we characterized phenolic composition, in vitro antioxidant effects, cytotoxic activity, inhibition induced-cisplatin chromosomal aberrations five seed extracts obtained with different proportions water (H2O) ethyl alcohol (EtOH). 50% H2O + EtOH was most promising extract because it presented higher total...
Visceral leishmaniasis (VL) has recently emerged in various urban and peri-urban areas of Brazil other countries. Understanding the urbanization VL requires identification risk factors associated with human canine infection. To determine predictors for VL, a survey was conducted 1,443 dogs, from which cohort selected (n = 455) evaluated approximately 26 months. Serology two enzyme-linked immunosorbent assays (ELISA): one Laboratory Zoonosis Belo Horizonte Health Department (LZOON)...
Toxoplasmosis, caused by the obligate intracellular parasite Toxoplasma gondii, affects about one-third of world's population and can cause severe congenital, neurological ocular issues. Current treatment options are limited, there no human vaccines available to prevent transmission. Drug repurposing has been effective in identifying anti-T. gondii drugs. In this study, screening COVID Box, a compilation 160 compounds provided "Medicines for Malaria Venture" organization, was conducted...
The diagnosis value of polymerase chain reaction (PCR) was assessed in patients from an area endemic for American cutaneous leishmaniasis (ACL) Brazil. Different forms clinical sample preservation and DNA extraction PCR were tested. 4 the skin biopsies suspected to have ACL as follows: imprinted on filter paper (FP); nitrocellulose (NP); frozen at -20 degrees C (FB); or immersed 70% ethanol (EB). extracted by elution FP NP enzyme digestion FB EB. Clinical examinations parasitological...
Gastrointestinal nematode infections significantly impact small ruminant production, causing substantial economic losses worldwide. The rising resistance to anthelmintics has led the search for alternative treatments, including phytotherapeutic approaches. This study investigates chemical composition and anthelmintic activity of crude extracts fractions from Simarouba berteroana, an endemic plant Hispaniola, against a multidrug-resistant isolate Haemonchus contortus. Chemical analyses...
Leishmaniasis is a neglected tropical disease with limited therapeutic options characterized by high toxicity, adverse side effects, and growing resistance to existing treatments. In this study, machine learning (ML) methods were employed design evaluate benzophenone xanthone derivatives as potential antileishmanial agents. A dataset of 73 compounds was curated, Quantitative Structure-Activity Relationship (QSAR) models developed using artificial neural networks (ANN), Random Forest (RF),...