A5025045851- Alzheimer's disease research and treatments
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and biological activity
- Medicinal Plants and Neuroprotection
- Multicomponent Synthesis of Heterocycles
- Polymer-Based Agricultural Enhancements
- Essential Oils and Antimicrobial Activity
- Histone Deacetylase Inhibitors Research
- Bioactive Compounds and Antitumor Agents
- Nanocomposite Films for Food Packaging
- Computational Drug Discovery Methods
- Ginkgo biloba and Cashew Applications
- Vagus Nerve Stimulation Research
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Electrospun Nanofibers in Biomedical Applications
- Tryptophan and brain disorders
- Adenosine and Purinergic Signaling
- Pain Mechanisms and Treatments
- Nonlinear Optical Materials Research
Universidade Estadual Paulista (Unesp)
2022-2023
Universidade de São Paulo
2023
Universidade Federal do Rio de Janeiro
2014-2018
Universidade Federal de Alfenas
2011-2018
Isobavachalcone (IBC) is a natural prenylated chalcone with broad spectrum of pharmacological properties. In this work, we newly synthesized and investigated the antibacterial activity IBC against Gram-positive, Gram-negative mycobacterial species. was active Gram-positive bacteria, mainly Methicillin-Susceptible Staphylococcus aureus (MSSA) Methicillin-Resistant (MRSA), minimum inhibitory concentration (MIC) values 1.56 3.12 µg/mL, respectively. On other hand, not able to act species (MIC >...
Abstract The development of efficient and environmentally friendly plant protection systems is one the major challenges for a sustainable agriculture future. Citrus canker caused by pathogen Xanthomonas citri subsp. ( X . ) affects all cultivated citrus species worldwide responsible enormous economic losses restrictions in international trade. Currently used commercial copper‐based formulations are origin contamination soil groundwater, affecting local ecosystems human health. A copper‐free...
Rheumatoid arthritis is an inflammatory autoimmune condition, and tumor necrosis factor-α (TNF-α) plays important role in its pathophysiology. In vitro, (E)-N'-(3,4-dimethoxybenzylidene)-N-methylbenzohydrazide (LASSBio-1359) has exhibited anti-TNF-α properties, vivo these effects are mediated via activation of adenosine receptor. This work investigates the antinociceptive action LASSBio-1359 murine models acute chronic pain. Male mice received intraperitoneal injection then were evaluated...
álzhei e 'sàDiseaseà áD àisàaà eu odege ativeàdisease characterized by a progressive memory loss and severe cognition decline, associated to degradation of cholinergic neurons in many areas central nervous system (CNS), with dramatic reduction neurotransmitters, specially acetylcholine.The illness progression is also accompanied behavior changes, leading individual incapacity depression, evolving dementia death.AD related cerebral aging located neurons, mainly at hippocampus basal...
LASSBio-1289 compound has been found to promote intense vasodilation and antihypertensive activity. It is an innovative compound, without structural similarities the three main classes of calcium antagonists (1,4-dihydropyridines, benzothiazepines phenylalkylamines) commonly used. A complete knowledge structure, including stereochemistry, essential lead optimization in drug discovery. For this reason, work we determined crystal structure novel vasoactive N-methyl-N-acylhydrazone derivative...
Pulmonary arterial hypertension (PAH) is a chronic cardiovascular disease that displays inflammatory components, which contributes to the difficulty of adequate treatment with available therapeutic arsenal. In this context, N-acylhydrazone derivative LASSBio-1359 was previously described as multitarget drug candidate able revert events associated progression PAH in animal models. However, spite having dual profile PDE4 inhibitor and adenosine A2A receptor agonist, does not present balanced...
A Doenca de Alzheimer (DA) e uma doenca neurodegenerativa, caracterizada pela diminuicao progressiva da memoria declinio severo cognicao, associados com a degradacao neuronios colinergicos em muitas areas do Sistema Nervoso Central (SNC), acompanhada dramatica reducao neurotransmissores, entre os quais acetilcolina (ACh) o mais importante. evolucao alteracoes comportamentais, que evoluem incapacitacao individuo depressao, culminando demencia morte. DA esta relacionada envelhecimento cerebral...