A5101687266- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Supramolecular Self-Assembly in Materials
- Myasthenia Gravis and Thymoma
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fibroblast Growth Factor Research
- 3D Printing in Biomedical Research
- Wound Healing and Treatments
- Carbohydrate Chemistry and Synthesis
- Acute Lymphoblastic Leukemia research
- Environmental Sustainability and Technology
- Transportation Systems and Logistics
- Glycosylation and Glycoproteins Research
- Construction Management and Sustainability
- Enzyme Production and Characterization
- Acute Myeloid Leukemia Research
- Advanced Polymer Synthesis and Characterization
- Proteins in Food Systems
- Synthesis and properties of polymers
- SARS-CoV-2 and COVID-19 Research
- TGF-β signaling in diseases
- Marine Biology and Environmental Chemistry
- Parkinson's Disease and Spinal Disorders
- Polymer-Based Agricultural Enhancements
- Medical research and treatments
RWTH Aachen University
2019-2024
DWI – Leibniz Institute for Interactive Materials
2020-2022
Sana Klinikum Offenbach
2018-2021
Hebrew University of Jerusalem
1991-2021
CSIRO Manufacturing
2019
Clayton Foundation
2019
FH Aachen
2019
ETH Zurich
2002-2006
Kiel University
2005
Humboldt-Universität zu Berlin
2001
Keratinocyte growth factor (KGF) is a potent mitogen for epithelial cells, and it promotes survival of these cells under stress conditions. In search KGF-regulated genes in keratinocytes, we identified the gene encoding transcription NF-E2-related 2 (Nrf2). Nrf2 key player cellular response. This might be particular importance during wound healing, where large amounts reactive oxygen species are produced as defense against invading bacteria. Therefore, studied repair process knockout mice....
BackgroundIn the neoadjuvant GeparSixto study, adding carboplatin to taxane- and anthracycline-based chemotherapy improved pathological complete response (pCR) rates in patients with triple-negative breast cancer (TNBC). Here, we present survival data potential prognostic predictive role of homologous recombination deficiency (HRD).Patients methodsPatients were randomized paclitaxel plus nonpegylated liposomal doxorubicin (Myocet®) (PM) or PM (PMCb). The secondary study end points...
We here performed an in-depth investigation of the behavior microgels (μgels) and their associated physicochemical transformations under shear force. Thermo- mechanoresponsive poly(N-vinylcaprolactam) (PVCL) μgels (d ∼ 400 nm) cross-linked with a force-responsive mechanofluorophore in different cross-linking degrees were synthesized examined. Fluorescence spectroscopy (FS), confocal laser scanning microscopy (CLSM), dynamic light scattering (DLS), cryogenic transmission electron (cryoTEM),...
Microgels (μgels) swiftly undergo structural and functional degradation when they are exposed to shear forces, which potentially limit their applicability in, e.g., biomedicine engineering. Here, poly(N-vinylcaprolactam) μgels that resist mechanical disruption through supramolecular hydrogen bonds provided by (+)-catechin hydrate (+C) synthesized. When +C is added the microgel structure, an increased resistance against force exerted ultrasonication observed compared crosslinked covalent...
Abstract The development of efficient and environmentally friendly plant protection systems is one the major challenges for a sustainable agriculture future. Citrus canker caused by pathogen Xanthomonas citri subsp. ( X . ) affects all cultivated citrus species worldwide responsible enormous economic losses restrictions in international trade. Currently used commercial copper‐based formulations are origin contamination soil groundwater, affecting local ecosystems human health. A copper‐free...
In the context of controlled delivery and release, proteins constitute a delicate class cargo requiring advanced platforms protection. We here show that mechanoresponsive diselenide-crosslinked microgels undergo ultrasound-triggered degradation in aqueous solution for release proteins. Simultaneously, are protected from chemical conformational damage by microgels, which disintegrate to water-soluble polymer chains upon sonication. The process is amount diselenide crosslinks, temperature,...
Hydrogels, as well colloidal hydrogels (microgels), are important materials for a large variety of applications in the biomedical field. Microgels with controlled pore size (meso- and macropores) required efficient nutrient support, modulation cell adhesion, removal metabolic products cultures, probiotic loading. Common microgel fabrication techniques do not provide sufficient control over sizes geometry. In this work, natural polysaccharide dextran modified methacrylate groups is used to...
We have developed a simple and versatile polymer coating method that provides excellent non-biofouling properties.
Glycosidases have long been used for the synthesis of glycosides by transglycosylation reactions. Especially glycosidases from hyperthermophilic bacteria are useful reactions under extreme reaction conditions, e.g., in presence organic solvents. We herein report facile enzymatic and purification 2-(β-galactosyl)-ethyl methacrylate (Gal-EMA) with recombinant hyperthermostable glycosidase Pyrococcus woesei high yields. Optimized conditions resulted gram-scale galactosylated monomer 88% yield....
Abstract Microgels have a wide range of applications, from catalysis to biomedical applications such as drug delivery in dispersion, or surface‐attached materials improve the biocompatibility implants anti‐fouling coatings. The first aim this work is understand morphology supramacromolecular, tannic acid (TA) crosslinked microgels using two‐dimensional 1 H NMR spectroscopy, and relaxometry. second study volume phase transition (VPT) TA‐crosslinked with different crosslinker densities...
At diagnosis, clonal gene rearrangement probes [retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3)] were detected in bone marrow samples from 71 of 153 patients with acute myelogenous (AML) (46%): 41 primary AML (pAML) (58%) and 30 secondary (42%). In all cases promyelocytic (AML-M3) RAR-alpha rearrangements (n = 9). Gene the Ig-JH TcR-beta GM-CSF IL-3...
Abstract This work focuses on the pH‐triggered disassembly of supramacromolecular microgels, which are composed temperature‐responsive poly( N ‐vinylcaprolactam) (PVCL) and natural polyphenol tannic acid (TA). A systematic investigation microgel formation demonstrates that a retarded addition during semi‐batch precipitation polymerization influences yield, chemical composition, properties microgels to great extent. Microgel properties, such as size, deformability, stability, can be easily...
Abstract Purpose Early detection of adenocarcinomas in the esophagus is crucial for achieving curative endoscopic therapy. Targeted biopsies suspicious lesions, as well four-quadrant biopsies, represent current diagnostic standard. However, this procedure time-consuming, cost-intensive, and examiner-dependent. The aim study was to test whether impedance spectroscopy capable distinguishing between healthy, premalignant, malignant lesions. An ex vivo measurement method developed examine...
Bio-Based Microgels In article number 2303783, Andrij Pich and co-workers report a versatile method to tune the porosity of dextran-based microgels. The size mesopores (≤50 nm) in diameter is regulated by variation polymer concentration. For generation macropores (300 690 nm), pH-degradable supramacromolecular nanogels are used as sacrificial colloidal template. Different sizes synthesized via precipitation polymerization subsequently embedded matrix microgels droplet-based microfluidics....
We have already shown that cytokine cocktails (IL-1β, IL-3, IL-6, SCF, GM-CSF) and/or lymphokine-activated killer (LAK) cells can reduce the amounts of clonal, CD34-positive mononuclear bone marrow (BM-MNC) in acute myeloid leukemia (AML). In addition, influence those LAK on clonogenic potential AML BM-MNC was investigated. BM colonies cultured agar during different stages disease were immunophenotyped situ: 17 patients at diagnosis, 14 complete remission, 8 relapse, healthy donors. A...