A5039501435- Smoking Behavior and Cessation
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Healthcare Systems and Practices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Inhalation and Respiratory Drug Delivery
- Diagnosis and treatment of tuberculosis
- School Health and Nursing Education
- Air Quality and Health Impacts
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Health, Medicine and Society
- Obesity, Physical Activity, Diet
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Behavioral Health and Interventions
- Nutritional Studies and Diet
- Substance Abuse Treatment and Outcomes
- Lung Cancer Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Nicotinic Acetylcholine Receptors Study
- Airway Management and Intubation Techniques
Sorbonne Université
2015-2024
Assistance Publique – Hôpitaux de Paris
2012-2024
Pitié-Salpêtrière Hospital
2012-2022
Université Paris 1 Panthéon-Sorbonne
2021
Centre Hospitalier Universitaire d'Angers
2021
Hôpital Charles-Foix
2012-2019
Université Sorbonne Nouvelle
2018
ParisTech
1997-2016
UPMC Health System
2016
Centre d'Immunologie et des Maladies Infectieuses
2014
Abstract Introduction Preliminary reports indicated that smokers could be less susceptible to coronavirus SARS-CoV-2, which causes Covid-19. However, once infected an increased risk of severe disease is reported. We investigated the association between smoking and COVID-19 during outbreak on a naval vessel. Methods conducted cross-sectional, observational study 1769 sailors same navy aircraft carrier at sea exposed time SARS-CoV2 investigate link tobacco consumption Results Among 1688...
Background. A positive influence of anticoagulant treatment in small cell lung cancer (SCLC) has been sug gested by experimental and clinical data. Methods. In a multicenter trial, 277 patients with SCLC were randomized either to receive or not subcutaneous heparin injections for 5 weeks at effective doses, which monitored blood coagulation tests. All received one the two chemotherapy regimens studied this eight courses case complete partial response, subsequently delayed thoracic...
The European Respiratory Society (ERS) recognizes that there are an increasing number of national and international guidelines for the management asthma, chronic obstructive pulmonary disease (COPD) other chest diseases. Some these recommend nebulizer use in specific circumstances, using either a jet or ultrasonic to administer drug airways lungs form aerosolized mist fine droplets. Although many patients with severe given nebulized treatment both hospitals their own homes, it is recognized...
Disseminated Mycobacterium avium infection is common in patients with acquired immune deficiency syndrome (AIDS), but no drug studies have been reported establishing antimicrobial activity against this organism a controlled, randomized trial. Clarithromycin, new macrolide, has M. vitro and animals, it not studied humans. In randomized, double-blind, placebo-controlled trial, we measured the ability of clarithromycin to reduce bacteremia AIDS disseminated infection. Of 23 initially enrolled,...
BACKGROUND Postoperative radiotherapy is commonly used to treat patients with completely resected nonsmall cell lung carcinoma, but its effect on overall survival has not been established. METHODS After undergoing complete surgical resection, 728 carcinoma (221 Stage I, 180 II, and 327 III) were randomized receive either postoperative at a total dose of 60 gray or observation only. The main end point was survival. RESULTS At the reference date, 218 355 in control group had died 262 373 died....
Bedaquiline is a new antibiotic that was approved for the treatment of multidrug-resistant (MDR) tuberculosis. We aimed to evaluate short-term microbiological efficacy and tolerability profile bedaquiline.We performed retrospective cohort study among patients with MDR tuberculosis receiving bedaquiline compassionate use between January 2010 July 2013 evaluated at 6 months treatment.A total 35 were included in study. Nineteen (54%) had extensively drug-resistant (XDR) tuberculosis, 14 (40%)...
Abstract Reactivation of latent Mycobacterium tuberculosis ( Mtb ) infection is a major complication anti-tumour necrosis factor (TNF)-α treatment, but its mechanism not fully understood. We evaluated the effect TNF antagonists infliximab (Ifx), adalimumab (Ada) and etanercept (Eta) on anti-mycobacterial immune responses in two conditions: with ex vivo studies from patients treated vitro addition to cells stimulated mycobacterial antigens. In both cases, we analysed response CD4 + T...
The use of the electronic cigarette is now common, but characteristic its remains largely unknown. Method: We have analysed parameters 1 million puffs recorded by a connected e-cigarette (Smokio®). Results: 2,001 to 23,123 (median=5,405) had been produced each 185 users during 116 days study period. mean number user/day 163±138 (median: 132) with large variations between and for same user. puffs/day decreases significantly on week-ends compared first 3 week (-4.60%; p<0.001). puffs/hour...
Disseminated infection with Mycobacterium avium is common late-stage acquired immunodeficiency syndrome (AIDS), and no antimicrobial agent has been found to be clearly effective.A multicenter open trial was conducted assess the activity clinical efficacy of clarithromycin--a new macrolide antibiotic--against disseminated M in 77 patients AIDS. Blood cultures were taken at baseline during treatment; side effects also evaluated.Mycobacterium eradicated from blood 11 (63%) 16 evaluable...
Background Outdoor secondhand smoke (SHS) concentrations are usually lower than indoor concentrations, yet some studies have shown that outdoor SHS levels could be comparable to under specific conditions. The main objectives of this study were assess exposure in terraces and other areas hospitality venues evaluate their potential displacement adjacent areas. Methods Nicotine respirable particles (PM2.5) measured 8 European countries. Hospitality the included night bars, restaurants bars....
Background. The effect of adjuvant chemotherapy after resection nonsmall cell lung cancer (NSCLC) remains an unresolved question. Methods. From October, 1982, to November, 1986, 267 patients with resected NSCLC were included in a randomized trial. allocated treatments either postoperative radiotherapy, 60 Gy 6 weeks (radiotherapy group = 129 patients), or three courses COPAC (cyclophosphamide, doxorubicin, cisplatin, vincristine, lomustine) followed by similar radiotherapy schedule...
Biopsies were taken from the upper and inner arm of 10 60-year-old male cigarette smokers compared with age-matched controls who non-smokers. The mean relative area, number thickness elastic fibres significantly increased in to controls. These results confirmed using antibodies elastin or microfibrillar component tissue. In broader more fragmented skin not as intensely stained those non-smokers ultrastructural alterations similar solar elastosis.
Abstract Background Knowledge of the correlates smoking is a first step to successful prevention interventions. The social norms theory hypothesises that students' behaviour linked their perception for use tobacco. This study was designed test associated with perceived norms, controlling other smoking. Methods In pencil-and-paper questionnaire, 721 second-year students in sociology, medicine, foreign language or nursing studies estimated number cigarettes usually smoked month. 31 additional...
Objectives: To explore if the dramatic decrease in price of e-cigarette has transformed this new product into a used for tobacco initiation among teenage population. Methods: The authors added question 2012 on yearly survey consumption Paris schoolchildren. study is conducted randomly selected sample from 2% classes since 1991. Results: 277 (8.1%) 3409 schoolchildren studied (including 575 non responders to question) reported having had an experience with e-cigarette. Experimentation rate...
In previous studies of the smoke from regular cigarettes and water pipes, we measured aerosol particle sizes in three streams; S1, inhaled by smoker, S2, released device itself S3, exhaled smoker. We used an electrostatic low-pressure impactor (ELPI), giving size distributions real time calculated median diameters, D50, dispersion (σg). This allowed us to predict airway deposition. addition, half-life air was as a measure risk others passive smoking. With same equipment, persistence liquid...
The effect of normative perceptions (social norms) on heavy episodic drinking (HED) behavior is well known in the U.S. college setting, but little work available other cultural contexts. objective this study therefore to assess whether social norms alcohol use are related HED France, taking account influential predictors.A cross-sectional survey was carried out among 731 second-year university students Paris region explore role 29 potential risk factors. probability and frequency drinkers...