A5011441991- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Multiculturalism, Politics, Migration, Gender
- Migration, Identity, and Health
- Viral Infections and Immunology Research
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
- Health, Medicine and Society
- HIV, Drug Use, Sexual Risk
- Heme Oxygenase-1 and Carbon Monoxide
- Historical Studies and Socio-cultural Analysis
- Aging, Elder Care, and Social Issues
- Molecular Biology Techniques and Applications
- Global Health and Surgery
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Viral-associated cancers and disorders
Université Paris Cité
2010-2025
Assistance Publique – Hôpitaux de Paris
2012-2025
Hôpital Avicenne
2013-2025
Sorbonne Université
2016-2025
Sorbonne Paris Cité
2013-2024
Hôpitaux Universitaires Paris-Ouest
2016-2021
Université Sorbonne Paris Nord
2000-2021
Institut Mondor de Recherche Biomédicale
2018-2021
Inserm
2018-2021
Agence Nationale de Recherches sur le Sida et les Hépatites Virales
2016-2020
Hepatitis delta virus (HDV) can cause severe acute and chronic liver disease in patients infected by hepatitis B virus. Interferon alpha at high doses, although poorly efficient, is the only treatment reported to provide some benefit delta. Pegylated interferon (PEG-IFN) has not yet been evaluated. Treatment usually monitored qualitative detection of HDV-RNA serum. In this study, safety efficacy PEG-IFN were assessed delta, serum kinetics determined using quantitative RT-PCR. Fourteen with...
Hepatitis delta virus is the only representative of Deltavirus genus, which consists 7 differentiated major clades. In this study, an eighth clade was identified from 3 distinct strains. genetic variability should be considered for diagnostic purposes. Clinical consequences diversity have yet to evaluated.
Hepatitis delta virus (HDV) is responsible for the most severe form of acute and chronic viral hepatitis. We previously proposed that Deltavirus genus composed eight major clades. However, few sequences were available to confirm this classification. Moreover, little known about structural functional consequences HDV variability. One practical consequence failure quantification assays properly detect or quantify plasmatic RNA. Between 2001 2014, 2,152 strains prospectively collected genotyped...
Infection by the hepatitis delta virus (HDV), a satellite of B (HBV), increases viral liver disease severity. Its diagnosis is thus vital for HBV-infected patients. HDV-RNA load (HDVL) should be assessed and monitored in plasma using real-time reverse-transcriptase polymerase chain reaction assays. Taking advantage recently-developed World Health Organization (WHO) HDV international standard (WHO-HDV-IS), first external quality control HDVL quantification was performed. Two panels samples...
ABSTRACT Hepatitis delta virus (HDV), in association with hepatitis B virus, is responsible for severe acute and chronic hepatitis. Treatment of the infection relies on long-term administration high doses alpha interferon (IFN), treatment efficiency monitored by detection anti-HDV immunoglobulin M HDV genome serum. Like case other viral infections, quantification serum should be useful follow-up infected patients. The aims this study were to develop a quantitative assay any type evaluate...
Abstract No recent data are available on hepatitis B virus (HBV) and Delta (HDV) prevalence in Mauritania. One thousand twenty pregnant women 946 patients visiting for routine checkups were screened HBV HDV infection. Demographic, epidemiological, ethnic, clinical, biological recorded. genotypes determined by sequencing phylogenetic analyses. In the cohorts, respectively, of HBsAg (10.7% 18.3%) anti‐HBcAb (66.3% 76.5%) indicated high endemicity. women, exposure to was significantly...
Niger is a west African country that highly endemic for hepatitis B virus (HBV) infection. The seroprevalence HBV surface antigen (HBsAg) about 20 %; however, there are no reports on the molecular epidemiology of strains spreading in Niger. In present study, isolates from sera 58 consecutive, asymptomatic, HBsAg-positive blood donors were characterized. Genotype affiliation was determined by amplification, sequencing and phylogenetic analysis preS1, polymerase/reverse transcriptase (RT/Pol)...
Escherichia coli is divided into four main phylogenetic groups, which each exhibit ecological specialization. To understand the population structure of E. in its primary habitat, we directly assessed relative proportions these phylogroups from stools 100 healthy human subjects using a new real-time PCR method, allows large number samples to be studied. The detection threshold for our technique was 0.1% population, i.e., 10(5) CFU/g feces; other methods based on individual colony analysis,...
Hepatitis delta virus (HDV) infection is the most severe form of viral hepatitis. Bulevirtide (BLV, Hepcludex® ) an HDV/HBV entry inhibitor approved in June 2020 European Union for adult patients with chronic hepatitis (CHD) and compensated liver disease positive HDV RNA load. This real-life preliminary report described early virological efficacy safety BLV six CHD disease: four were treated combination (2 mg/d subcutaneous injection) pegylated interferon (PEG-IFN) two monotherapy. Four...
Background/aims Treatment of chronic delta hepatitis is long and difficult better monitoring needed. Methods In this study, virus (HDV) RNA, B surface antigen (HBsAg) (HBV) DNA were retrospectively quantified in 53 patients with e (HBeAg)-negative delta. Twenty-one had received 28 courses 3–5 MU interferon-α2b (IFN-α2b) thrice weekly for a median 12.6 months (interquartile range [IQR]: 7.3–31.6), five eight 100 mg lamivudine (LAM) daily 23.6 (IQR: 8.4–61.5) 27 untreated. The controls 54...
Hepatitis D virus (HDV) is responsible for fulminant hepatitis and liver failure accelerates evolution toward cirrhosis hepatocellular carcinoma in B (HBV)-infected patients. To date, treatment relies upon long-term administration of pegylated alpha-interferon with a sustained virological response 30% the Very recently, new, promising anti-HDV therapies have been developed are already being used clinical trials. HDV RNA viral load (HDVL) monitoring must be an integral part management...
Hepatitis delta virus (HDV) is a satellite of hepatitis B (HBV), which requires the HBV surface antigen (HBsAg) for its assembly and propagation. Although countries affected by infection in Africa are well identified, data on HDV still scarce, like Nigeria, where endemic. In this study, we aimed to determine prevalence identify circulating genotypes/strains country. A nationwide study was performed 1281 HBsAg-positive samples collected from patients across eleven sites drawn six geopolitical...
Ten Hepatitis B virus (HBV) genotypes, as well numerous subgenotypes, have been described in well-characterized ethnogeographical populations. Martinique has at a crossroads between Africa, Europe, India and the Americas because of slave trade (17th-19th centuries), followed by an important immigration Indian West African workers. In this work, we aimed to study molecular epidemiology HBV infection according unique settlement pattern. To that end, blood samples from 86 consecutive...
The majority of patients with acute febrile jaundice (>95%) identified through a yellow fever surveillance program in the Democratic Republic Congo (DRC) test negative for antibodies against virus. However, no etiological investigation has ever been carried out on these patients. Here, we tested hepatitis A (HAV), B (HBV), C (HCV), D (HDV), and E (HEV) viruses, all which can cause jaundice, included DRC. On total 498 serum samples collected from suspected cases January 2003 to 2012,...
The prevalence of hepatitis delta virus (HDV) infection among persons living with B (HBV) and its impact on liver-related complications in West Africa are ill-defined. Wetested a large urban HBV cohort Senegal for the presence HDV/HBV co-infection evaluated association liver fibrosis. We included positive surface antigen (HBsAg) enrolled SEN-B since 2019. Anti-HDV antibodies (HDVAb) were tested using Anti-HD Diasorin LiaisonXL test, HDV RNA was measured RT-qPCR genotyping determined through...
ABSTRACT Hepatitis D is estimated to affect 12 million people worldwide and caused by the hepatitis virus (HDV), a defective that requires presence of B (HBV) for infection. Here, we report new recombinant antigen (DTH10.1) detect anti-HDV IgG antibodies, designed include consensus sequence HDV antigen, based on bioinformatic analysis eight genotypes. Using serum samples from patients living in endemic area Brazilian Amazon basin, enzyme-linked immunosorbent assay (ELISA) this protein...
ABSTRACT A human immunodeficiency virus (HIV)-negative patient with no risk factor experienced HIV type 1 (HIV-1) primary infection 4 weeks after being hospitalized for surgery. Among the medical staff, only two night shift nurses were identified as HIV-1 seropositive. No exposure to blood was evidenced. To test hypothesis of a possible nurse-to-patient transmission, phylogenetic analyses conducted using genomic regions ( pol reverse transcriptase [RT] and env C2C4), each compared reference...
Abstract The isolates of human herpesvirus‐6 (HHV‐6), a betaherpesvirus closely related to cytomegalovirus (HCMV), are classified as either variants A (HHV‐6A) or B (HHV‐6B) but their intravariant variability has not been studied extensively so far. full‐length genes envelope glycoproteins gB and gH from 40 distinct HHV‐6‐DNA‐positive specimens 11 laboratory strains were amplified using PCR, nucleotide sequence determined. Nucleotide divergences observed at 156 (6.2%) 98 (4.7%) positions in...