The majority of patients with acute febrile jaundice (>95%) identified through a yellow fever surveillance program in the Democratic Republic Congo (DRC) test negative for antibodies against virus. However, no etiological investigation has ever been carried out on these patients. Here, we tested hepatitis A (HAV), B (HBV), C (HCV), D (HDV), and E (HEV) viruses, all which can cause jaundice, included DRC. On total 498 serum samples collected from suspected cases January 2003 to 2012,...

In Gabon, a central African country, human immunodeficiency virus (HIV) and hepatitis B (HBV) are endemic. recent study, conducted in semi-urban area (Franceville, Gabon), HBV infection was found to be more prevalent among HIV infected individuals. This study aims investigate the prevalence genetic diversity of individuals, predominantly under antiretroviral therapy, living fully urbanized area: Libreville, capital Gabon. Serological molecular tests were performed detect patients with...

<h3>Importance</h3> Since the emergence of COVID-19 in central China, sub-Saharan African countries, with exception South Africa, have been relatively spared during pandemic. Consequently, few descriptive studies from this region are available. <h3>Objective</h3> To describe clinical characteristics and outcomes patients infection Gabon, March to June 2020. <h3>Design, Setting, Participants</h3> A single-center, cross-sectional study 837 was conducted 2020 Armed Forces Hospital Libreville,...

Integrated data on hepatitis B virus (HBV) patterns, HBV genotypes and mutations are lacking in human immunodeficiency type 1 (HIV-1) co-infected patients from Africa. This survey was conducted 2010-2013 among 762 HIV-1-positive adults Gabon who were predominantly treated with 3TC-based antiretroviral treatment. patterns identified using immunoassays detecting total antibody to core antigen (HBcAb), surface (HBsAg), IgM HBcAb, e (HBeAg), HBsAg (HBsAb) an in-house real-time PCR test for DNA...

Abstract Worldwide, the development of hepatocellular carcinoma (HCC) is known to be influenced by several hepatitis B viral factors. However, effect virus (HBV) genotypes and a landscape nucleotide changes affecting precore (PC) basal core promoter (BCP) during infection leading HCC remain largely unknown in Central Africa region. Thus, we performed case‐control study on patients with HBV‐related matched controls without but chronic HBV infection. Genotypes mutation spectrums were evaluated...

Access to antiretrovirals has increased the life expectancy of patients living with HIV. However, HIV-viral hepatitis coinfections in countries endemic for these infections make management more difficult. To determine extent Gabon, we investigated markers B, C, and E viruses 762 adults infected HIV-1 by ELISA. We used real-time PCR quantify plasma HBV DNA (HBV VL) amplified HCV HEV RNA nested RT-PCR PCR.The seroprevalence chronic B infection was 9.3 %. Among isolated HBcAc profiles,...

To estimate the seroprevalence of anti-SARS-CoV-2 antibodies in general population Gabon, Central Africa. From May to July 2021, a cross-sectional study involving participants recruited three districts Gabon was conducted. Eligible who provided written informed consent were tested for using simple rapid diagnostic assay. Overall, 1609 recruited, 1361 (84.6%) from urban sites and 248 (15.4%) rural area. The estimated overall 13.1% (95% CI 11.4-14.8%). risk seropositivity increased with age,...

Context: The Human Immunodeficiency Virus (HIV) continues to be the main public health challenge in Gabon. latest studies highlight a high rate of virological failure and HIV drug resistance semi-rural In Libreville, data is sparse, on for former first line new first-line regimen lacking. Methods: Between January 28th, 2019, 31st, 2020, we received patient living with (PLWHA) CD4 counts, HIV-1 viral load, and/or genotyping mutation resistance. We used BD FACSPresto count, Biocentric Generic...

BACKGROUND:Takayasu disease is a rare affecting large vessels, particularly the aorta and its main branches. The affected arteries become partially occluded. more frequent in women under 40 years of age, with ratio to men 8: 1. CASE REPORT:We report case 39-year-old woman who was admitted medical ward at Military Hospital Gabon. She presented multiple aneurysms, arterial stenosis, positive tuberculin skin test diagnosed Takayasu associated latent tuberculosis infection. This first be...

Mycoplasma hominis and Ureaplasma urealyticum are microorganisms involved in many pathologies intrauterine infections.Vaginal wall swabs were taken from 278 women for mycoplasma detection to study the antimicrobial susceptibility using IST2 Kit (bioMérieux).We able document enrolled study, 64.7% have infections caused by U. urealyticum, 22.7% M. hominis, 19.4 % of coinfections involving both germs.Such observed age groups between 18 42 years.Other socio-demographic characteristics studies...

Background Gabon is an endemic area for human immunodeficiency virus (HIV) and hepatitis C (HCV) the risk of co-infection high. Method Between November 2015 April 2016, we conducted retrospective study on HCV infection among people living with HIV/AIDS (PLHA). A total 491 PLHA were included in this tested presence infection. HIV viral loads obtained using Generic Load® assay CD4+ T cells count was performed BD FACSCount™ CD4 reagents. screening MP Diagnostics ELISA 4.0 kit. genotypes...

Chronic liver diseases still represent a worrying public health issue in Sub-Saharan Africa. In this region, emphasis is generally made on hepatocellular carcinoma (HCC) albeit cirrhosis (LC) also responsible for an important death toll. Very few studies have compared the presentation and etiologies of cancer Middle We conducted comparative retrospective analysis 74 134 cases patients with HCC LC treated Libreville, Gabon. Viral or lifestyle risk factors, clinical symptoms, biological...

in order to promote rapid care of HIV-positive people and reduce the human immunodeficiency virus (HIV) transmission Gabon, national screening algorithm is essentially based on diagnostic tests (RDTs). However, most these RDTs are not evaluated. Their sensitivities specificities remain unknown locally. The aim this study was determine performance 3 used for HIV-1> Gabon.of one hundred sixteen (116) samples tested, 60 plasmas were HIV-1 positive with known genotypes viral loads; 51 sera...

Human African Trypanosomiasis (HAT) is an infectious disease due to a protozoa parasite of the Trypanosoma genus. In West and Central Africa, this caused by subspecies brucei gambiense. Several foci are currently active causing death hundreds people in endemic areas. article, we report two cases gambiense HAT one Indonesian Gabonese men historical Gabon 2019. Both patients had fever with temperatures above 38°C, altered state consciousness, cachexia, multiple dermabrasions on abdomen related...

HBV genotyping was performed by sequencing and phylogenetic analyses of the surface (S) core (C) fragments. Briefly, DNA first extracted from 400 µL plasma eluted in 100 pure water, using QIAamp Viral Mini Kit (QIAGEN, Courtaboeuf, France) followed semi-nested PCR amplification S (930 bp) C (1010 gene fragments MP Taq Core Kits 25 (MP Biomedical Diagnostic, Europe). The fragment as described elsewhere. (Hu X, et al., 2000 [PMID:10677515] ; Makuwa M 2006 [PMID: 16847965]; Olinger CM al.,2006...

HBV DNA Real Time Quantification according to ARNS 12187 project Using the Arrow extractor (NorDiag, Biotrin International, Ireland), was extracted from 240 μl of plasma, pre-treated with10 proteinase K, using Viral NA extraction kit, manufacturer’s instructions during 45 min. Template eluted into 60 kit elution buffer. Besides clinical samples, quantification standard (Acrometrix Panel, Acrometrix, Menica, CA, USA) also for each run with same protocol and1:10 diluted (from 50,000,000IU/mL...

Extrapulmonary forms of tuberculosis (TB) are on the rise in sub-Saharan Africa and pose a major public health problem. The spine is most frequent location musculoskeletal tuberculosis. Involvement causes severe back pain weakness lower extremities. We report 11 cases TB spondylodiscitis, commonly referred to as Pott's disease, who presented internal medicine department at Military Hospital Gabon (HIA OBO).