A5002632928- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV/AIDS Research and Interventions
- Liver Disease and Transplantation
- SARS-CoV-2 detection and testing
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
- Neonatal Respiratory Health Research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Conditions and Treatments
- Congenital Heart Disease Studies
- Pancreatitis Pathology and Treatment
- Data-Driven Disease Surveillance
- COVID-19 and Mental Health
- Cystic Fibrosis Research Advances
- Housing, Finance, and Neoliberalism
- Cardiac, Anesthesia and Surgical Outcomes
- Food Security and Health in Diverse Populations
- Intestinal and Peritoneal Adhesions
- Diet, Metabolism, and Disease
Queen's University
2023-2025
McGill University Health Centre
2007-2023
Montreal Children's Hospital
2023
Washington University in St. Louis
2020-2022
Services Hospital
2022
Mayo Hospital
2021-2022
McGill University
2006-2021
Canadian Blood Services
2021
University of Agriculture Faisalabad
2018
Institute of Food Science and Technology
2018
Despite the availability of safe and efficacious coronavirus disease 2019 vaccines, a significant proportion American public remains unvaccinated does not appear to be immediately interested in receiving vaccine.
Abstract Background Case detection underestimates the burden of COVID‐19 pandemic. Following first wave, we estimated seroprevalence severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) among blood donors across Canada. Study Design and Methods This serial cross‐sectional study was conducted between May 9 July 21, 2020 from donating at all Canadian Blood Services locations. We used Abbott Architect assay to detect SARS‐CoV‐2 IgG antibodies retention plasma. Seroprevalence...
Chronic and persistent lung infections cause the majority of morbidity mortality in patients with cystic fibrosis (CF). Galactosyl ceramide has been previously shown to be involved Pseudomonas internalization. Therefore, we assessed levels plasma CF compared them healthy volunteers using high-performance liquid chromatography followed by mass spectrometry. Our results demonstrate that display significantly lower several sphingolipid species, specifically C14:0, C20:1, C22:0, C22:1, C24:0...
Co-infection of HCV with HIV has been associated more rapid progression HCV-related disease. HCV-specific T-cell immune responses, which are essential for disease control, attenuated in co-infection HIV. exhaustion recently implicated the deficient control chronic viral infections. In current study, we investigated role programmed death-1 (PD-1) and immunoglobulin mucin domain-containing molecule-3 (Tim-3) expression during HCV/HIV co-infection. We show that co-infection, both total T cells...
Hepatitis C virus (HCV) has emerged as one of the most vexing health problems facing HIV-infected persons. Due largely to injection drug use (IDU),430% patients are co-infected with HCV in developed countries 10 million worldwide. In 1999, 11 194 Canadians were estimated be and this number likely increased substantially since. infection also increasingly been reported HIV-positive men having sex (MSM) who have not used drugs. Since advent highly active antiretroviral therapy (HAART) there...
<h3>Background:</h3> In Canada, interferon-free, direct-acting antiviral hepatitis C virus (HCV) regimens are costly. This presents challenges for universal drug coverage of the estimated 220 000 people with chronic HCV infection nationwide. The study objective was to appraise criteria reimbursement 4 antivirals in Canada. <h3>Methods:</h3> We reviewed simeprevir, sofosbuvir, ledipasvir<b>-</b>sofosbuvir and paritaprevir<b>-</b>ritonavir<b>-</b>ombitasvir plus dasabuvir 10 provinces 3...
Background. Direct-acting antivirals (DAAs) against hepatitis C virus (HCV) have been described as revolutionary. However, it remains uncertain how effective these drugs will be for individuals coinfected with human immunodeficiency (HIV)–HCV. Bridging this gap between efficacy and effectiveness requires a focus on the generalizability of clinical trials. Methods. Generalizability DAA trials was assessed by applying eligibility criteria from 5 trials: NCT01479868, PHOTON-1 (NCT01667731),...
Patients with cystic fibrosis (CF) and Cftr-knockout mice (CF mice) display an imbalance in fatty acids, high arachidonic acid (AA) low docosahexaenoic (DHA) concentrations. Our recent studies demonstrated defects another class of lipids, ceramides, patients CF mice. This study investigates the relationship between ceramide, AA, DHA, correction lipid imbalances after treatment fenretinide. Concentrations ceramide were assessed plasma from 58 adult 72 healthy control subjects. After 28 days...
HIV is known to have a negative impact on the progression of hepatitis C virus (HCV) infection, whereas reverse remains unclear. We examined spontaneous clearance HCV CD4(+) T-lymphocyte count before and after initiation antiretroviral therapy (ART) in HIV-HCV coinfected adults.Data were analysed from participants Canadian, multisite prospective cohort HIV-infected adults with serologic evidence infection. The rate change was determined using multivariate mixed linear regression comparing...
Abstract Background Direct acting antivirals ( DAA s) have revolutionized hepatitis C HCV ) treatment with >90% cure rates even in real‐world studies, giving hope that can be eliminated. However, for s to a population‐level impact on the burden of disease, uptake needs expanded. We investigated temporal trends and evaluated factors associated second‐generation initiation efficacy among key HIV ‐ co‐infected populations Canada. Methods The Canadian Co‐Infection Cohort Study prospectively...
ABSTRACT Steatotic liver disease is prevalent among people with hepatitis C virus (HCV). The new definition of metabolic dysfunction–associated steatotic (MASLD) emphasises the drivers steatosis and recognises its frequent coexistence other chronic diseases, including HCV. We aimed to evaluate association coexisting MASLD HCV fibrosis. Individuals who underwent transient elastography (TE) associated controlled attenuation parameter (CAP) were included from two clinical centres. significant...
Caffeine, the most often taken psychoactive stimulant, is said to have contradictory effects on tear film dynamics. Objectives: To determine effect of caffeinated coffee tears secretion. Methods: Quasi experimental study was conducted from January 2023 May 2024 at Superior University Lahore including 86 subjects ages between 18-35 years by using convenient sampling technique. After visual acuity assessment, secretion participants checked Schirmer test strips. Tears all noted before and after...
Abstract Introduction There is currently no published data on the effectiveness of DAA treatment for elimination HCV infection in HIV ‐infected populations at a population level. However, number relevant studies and initiatives are emerging. This research aims to report cascade care emerging that being evaluated / co‐infected context implementation science theory. Methods underway were identified. Context, intervention characteristics synthesized frameworks. Results Seven identified...
Abstract Background The cascade of care, commonly used to assess HIV and hepatitis C (HCV) health service delivery, has limitations in capturing the complexity individuals’ engagement patterns. This study examines dynamic nature mortality trajectories among people with HCV. Methods We data from Canadian HIV-HCV Co-Infection Cohort, which prospectively follows 2098 participants 18 centers biannually. Markov multistate models were evaluate sociodemographic clinical factors associated...
Objectives Hepatitis C virus ( HCV ) has emerged as an important health problem in the era of effective HIV treatment. However, very few data exist on status and disease burden / ‐coinfected anadians. Methods patients were enrolled prospectively a multicentre cohort from 16 centres across anada between 2003 2010 followed every 6 months. We determined rates first liver fibrosis or endstage ESLD event all‐cause mortality since enrolment calculated standardized ratios compared with general...
High costs of direct-acting antivirals (DAAs) have led health-care insurers to limit access worldwide. Using a natural experiment, we evaluated the impact removing fibrosis stage restrictions on hepatitis C (HCV) treatment initiation rates among people living with human immunodeficiency virus (HIV), and then examined who was left be treated.
HIV-infected patients are at increased risk of nonalcoholic steatohepatitis (NASH). Vitamin E is recommended for treatment NASH in the general population. However, its safety and efficacy among remain unknown.Single-centre, phase IV, open-label, single arm clinical trial.HIV mono-infected without significant alcohol intake or viral hepatitis coinfection were included. The diagnosis was based on co-existence fatty liver, diagnosed by controlled attenuation parameter (CAP) least 248 dB/m...
Despite potential negative consequences, HIV/hepatitis C virus (HCV) co-infected patients may discontinue antiretroviral treatment (ART) for several reasons. We examined the impact of ART interruption on liver fibrosis progression in adults, using aspartate aminotransferase-to-platelet ratio index (APRI) as a surrogate marker fibrosis.Data were analyzed from multisite prospective cohort 541 HIV-HCV adults. was included time-updated variable and defined cessation all antiretrovirals at least...