A5045448757- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Sex work and related issues
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Herpesvirus Infections and Treatments
- Cervical Cancer and HPV Research
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- Animal Virus Infections Studies
- Alcohol Consumption and Health Effects
- Homelessness and Social Issues
Public Health Service of Amsterdam
2016-2025
Amsterdam University Medical Centers
2018-2025
University of Amsterdam
2016-2025
Institute of Infection and Immunity
2014-2024
Amsterdam Institute for Addiction Research
2024
GGD Amsterdam
2002-2024
National Institute for Public Health and the Environment
2013-2024
KWR Water Research Institute
2024
Amsterdam UMC Location University of Amsterdam
2013-2023
Stichting HIV Monitoring
2015-2023
A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is duration of acquired immunity. Insights from infections with four seasonal human coronaviruses might reveal common characteristics applicable to all coronaviruses. We monitored healthy individuals for more than 35 years and determined that reinfection same occurred frequently at 12 months after infection.
Human immunodeficiency virus (HIV)-infected individuals may be at increased risk of age-associated noncommunicable comorbidities (AANCCs).Cross-sectional analyses AANCC prevalence (including cardiovascular, metabolic, pulmonary, renal, bone, and malignant disease) factors in a prospective cohort study HIV type 1-infected HIV-uninfected controls, who were aged ≥45 years comparable regarding most lifestyle demographic factors.HIV-infected participants (n = 540) had significantly higher mean...
The management of patients with atrial fibrillation (AF) is often inadequate due to deficient adherence the guidelines. A nurse-led AF clinic providing integrated chronic care improve guideline and activate in their role, may effectively reduce morbidity mortality but such has not been tested a large randomized trial. Therefore, we performed clinical trial compare routine AF. We randomly assigned 712 usual care. Nurse-led consisted guidelines based, software supported supervised by...
Although 20%-40% of persons with acute hepatitis C virus (HCV) infection demonstrate spontaneous clearance, the time course and factors associated clearance remain poorly understood. We investigated to predictors among participants HCV using Cox proportional hazards analyses. Data for this analysis were drawn from an international collaboration nine prospective cohorts evaluating outcomes after infection. Among 632 HCV, 35% female, 82% Caucasian, 49% had interleukin-28 (IL28)B CC genotype...
ABSTRACT Objectives To investigate the impact of harm‐reduction programmes on HIV and hepatitis C virus (HCV) incidence among ever‐injecting drug users (DU) from Amsterdam Cohort Studies (ACS). Methods The association between use harm reduction seroconversion for human immunodeficiency (HIV) and/or was evaluated using Poisson regression. A total 714 DU were at risk HCV during follow‐up. Harm measured by combining its two most important components—methadone dose needle exchange programme...
Since 2000 outbreaks of sexually transmitted hepatitis C Virus (HCV) infections have been reported among HIV-infected men who sex with (MSM). We studied the prevalence and determinants HCV-infection MSM attending a large infection (STI) clinic in Netherlands.In 2007-2008, 3125 attendees STI Amsterdam, including 689 MSM, participated an anonymous biannual crosssectional survey. Participants were interviewed screened for HIV HCV antibodies. Additionally, all anti-HCV positive individuals...
Populations in Europe are becoming increasingly ethnically diverse, and health risks differ between ethnic groups. The aim of the HELIUS (HEalthy LIfe an Urban Setting) study is to unravel mechanisms underlying impact ethnicity on communicable non-communicable diseases. a large-scale prospective cohort being carried out Amsterdam, Netherlands. sample made up Amsterdam residents Surinamese (with Afro-Caribbean South Asian-Surinamese as main groups), Turkish, Moroccan, Ghanaian, Dutch origin....
Ethnic minority groups usually have a more unfavourable disease risk profile than the host population. In Europe, ethnic inequalities in health been observed relatively small studies, with limited possibilities to explore underlying causes. The aim of Healthy Life an Urban Setting (HELIUS) study is investigate causes (the unequal burden of) diseases across groups, focusing on three categories: cardiovascular diseases, mental and infectious diseases.The HELIUS prospective cohort among six...
To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living Amsterdam, the Netherlands, as has been shown for American women.Women (18-34 years, non-pregnant, N = 610) representing six largest ethnic groups (Dutch, African Surinamese, South-Asian Turkish, Moroccan, and Ghanaian) were sampled from population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior. DNA extracted self-sampled...
Emerging and future SARS-CoV-2 variants may jeopardize the effectiveness of vaccination campaigns. Therefore, it is important to know how different vaccines perform against diverse variants.
Large-scale vaccination campaigns have prevented countless hospitalizations and deaths due to COVID-19. However, the emergence of SARS-CoV-2 variants that escape from immunity challenges effectiveness current vaccines. Given this continuing evolution, an important question is when how update vaccines antigenically match circulating variants, similarly seasonal influenza viruses where antigenic drift necessitates periodic vaccine updates. Here, we studied by assessing neutralizing activity...
Symptoms of post-acute sequelae COVID-19 (PASC) may improve following SARS-CoV-2 vaccination. However few prospective data that also explore the underlying biological mechanism are available. We assessed effect vaccination on symptomatology participants with PASC, and compared antibody dynamics between those without PASC.
In the 2022 multicountry mpox (formerly named monkeypox) outbreak, several countries offered primary preventive vaccination (PPV) to people at higher risk for infection. We study vaccine acceptance and its determinants, target tailor public health (communication-) strategies in context of limited supply Netherlands.
We retrospectively screened 1836 men who have sex with (MSM) participating in the Amsterdam Cohort Studies (1984–2003) for hepatitis C virus (HCV) antibodies. HCV incidence was 0.18/100 person-years (PY) HIV-positive MSM (8/4408 PY [95% confidence interval [CI], 0.08–0.36]) but 0/100 without HIV (0/7807 CI, 0.00–0.05]). After 2000, among increased 10-fold to 0.87/100 (5/572 0.28–2.03]). Additional hospital cases (n=34) showed that acquired infection after 2000 reported high rates of...
Objectives To evaluate the effect of highly active antiretroviral therapy (HAART) on sexual behaviour homosexual men, we conducted (i) an ecological study time trends in and sexually transmitted diseases; (ii) a HAART-effect focused practice unprotected anogenital sex. Design Subjects were participants ongoing Amsterdam Cohort Studies (ACS) among initiated 1984. Data for represented all ACS visits by HIV-1-positive -negative who entered at or below 30 years age followed until 35 (n = 1062)....
<b>Background: </b> Botulinum toxin type A (BTA) is replacing trihexyphenidyl as the treatment of choice for idiopathic cervical dystonia (ICD), but there has never been a direct comparative study. Methods: This trial compares effectiveness BTA with that in prospective, randomized, double-blind design. Sixty-six consecutive patients ICD were randomized to tablets plus placebo injection or injections. Table tswere administered daily according fixed schedule. Dysport saline was injected under...
Objective: Reducing viral load, highly active antiretroviral therapy has the potential to limit onwards transmission of HIV-1 and thus help contain epidemic spread. However, increases in risk behaviour resurgent epidemics have been widely reported post-highly therapy. The aim this study was quantify impact that had on epidemic. Design: We focus among men who sex with Netherlands, which well documented over past 20 years within several long-standing national surveillance programs. Methods:...
Background: Recent data indicate that seroprevalence of sexually transmitted hepatitis C virus (HCV) infection among MSM is stabilizing in Amsterdam. However, little known about the incidence HCV re-infection who have cleared their infection. We, therefore, studied HIV-infected were RNA-negative following treatment acute primary Methods: Our study population comprised at two large HIV outpatient clinics Amsterdam, previously diagnosed with a and tested end treatment. We defined as detectable...
The hepatitis C virus (HCV) epidemic is ongoing in the United States and globally. Incidence rates remain high, especially young adult injection drug users. New outbreaks of HCV among adults, predominantly suburban rural areas, have emerged may be fueling an increase HCV. This paper discusses some key prevention strategies that to date not been widely researched or implemented, wherein future efforts focused: (1) reducing sharing preparation equipment; (2) screening, testing counseling; (3)...