A5056504094- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Adolescent and Pediatric Healthcare
- Adolescent Sexual and Reproductive Health
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Homelessness and Social Issues
- Sex work and related issues
- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- HIV/AIDS Impact and Responses
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Toxicity Studies
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- Bipolar Disorder and Treatment
- Liver Disease and Transplantation
- Kawasaki Disease and Coronary Complications
University College London
2016-2025
MRC Clinical Trials Unit at UCL
2016-2025
Medical Research Council
2014-2024
PENTA Foundation
2016-2024
University of London
1999-2023
Public Health England
2014-2016
South West London and St George's Mental Health NHS Trust
2014-2016
St George’s University Hospitals NHS Foundation Trust
2014-2016
Brigham and Women's Hospital
2015
St George's, University of London
2014
Limited evidence is available on the real-world effectiveness of BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) and specifically infection with omicron variant among children 5 to 11 years age.
Background. Recent evidence suggests that decreases in morbidity and mortality cohorts of adults infected with human immunodeficiency virus (HIV) are showing signs reversal. We describe changes over time these characteristics the response to treatment among children United Kingdom Ireland perinatally acquired HIV infection, many whom now adolescents. Methods. analyzed prospective cohort data reported National Study Pregnancy Childhood (NSHPC) Collaborative Paediatric Study. Results. By mid...
Background Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric cohorts and cohort networks, allowing comparisons in "real-life" settings across multiple regions. We describe geographic temporal characteristics mortality outcomes APHs regions, including South America Caribbean, North America, Europe, sub-Saharan Africa, Southeast Asia. Methods findings Through Collaborative...
Background. Few studies consider the incidence of individual AIDS-defining illnesses (ADIs) at higher CD4 counts, relevant on a population level for monitoring and resource allocation.
In England, the low prevalence of HIV among injecting drug users during 1990s was attributed in part to introduction harm reduction interventions late 1980s. Also, hepatitis C virus thought be relatively compared with other countries, at around 40% overall and 15% those who had been drugs for less than six years.1 We carried out a prospective cohort study new London estimate incidence HIV. In 2001, we recruited from community settings mainly London, but also Brighton, 428 were aged below 30...
Abstract Oral fluid testing is an effective alternative to serum antibody for surveillance of human immunodeficiency virus (HIV) and hepatitis B infections, being extended C infections. The objective this study was determine compare the sensitivity specificity a modified commercial assay detection (anti‐HCV) in oral fluids collected by two different collection devices (the Epitope OraSure™ Sarstedt Salivette™) dried fingerprick blood spots. In study, 253 anti‐HCV seropositive patients 394...
Objective To establish the prevalence of antibodies to HIV (anti-HIV) and associated risk factors among injecting drug users (IDU) in Togliatti City, Samara Oblast, Russian Federation. Design An unlinked anonymous cross-sectional community recruited survey with oral fluid sample collection. Methods Between September October 2001, 426 IDU were by trained fieldworkers. Participants completed an interviewer administered questionnaire, samples tested for anti-HIV. Univariate multivariate...
Evidence suggests rapid diffusion of injecting drug use and associated outbreaks HIV among users (IDUs) in the Russian Federation Eastern Europe. There remains a need for research non-treatment community-recruited samples IDUs to better estimate dynamics transmission improve treatment health services access. We compare two sampling methodologies "respondent-driven sampling" (RDS) chain referral using "indigenous field workers" (IFS) investigate relative effectiveness RDS reach more marginal...
Summary. The objective of this study was to assess whether introducing dried blood spot testing can increase hepatitis C virus (HCV) diagnostic testing. A cluster randomized controlled trial conducted. Sites were matched into pairs, with one site in each pair randomly allocated receive the intervention (training and use spot). Data collected from all sites for 6 months before after start intervention. participants 22 specialist drug clinics six prisons England Wales. main outcome measure...
Objective: In the absence of treatment, rapid progression to AIDS occurs in approximately 20% HIV-1-infected infants over first year life. The prognosis these children has considerably improved with highly active antiretroviral therapy. As data from well resourced countries are lacking, objective this collaborative study was evaluate impact early treatment vertically infected infants. Design: Children born HIV-infected mothers between 1 September 1996 and 31 December 2004, who were diagnosed...
Objectives Mortality in young people with perinatally acquired HIV infection ( PHIV ) following transfer to adult care has not been characterized the UK . We conducted a multicentre audit establish number of deaths and associated factors. Methods Fourteen clinics caring for infected reported 30 S eptember 2011 on proforma. Deaths were matched Collaborative Paediatric Study, clinical database ‐infected children / I reland, describe characteristics paediatric those who died post‐transition....
Future strategies aiming to achieve HIV-1 remission are likely target individuals with small reservoir size.We retrospectively investigated factors associated DNA levels in European, perinatally HIV-infected children starting antiretroviral therapy (ART) <6 months of age.Total was measured from 51 long-term suppressed aged 6.3 years (median) after initial viral suppression. Factors log10 total were analyzed using linear regression.At ART initiation, median [IQR] 2.3 [1.2-4.1] months, CD4% 37...
Background Hepatitis C virus (HCV) prevalence and incidence among injecting drug users (IDUs) has increased in London rest of UK. To inform public health action, mathematical modelling is used to explore the possible impact strategies decrease syringe sharing.
Children with perinatally acquired HIV-1 infection are surviving into adolescence and increasingly transitioning toward adult services. Planning appropriate services in life requires an understanding of their progress through pediatric care. We describe the demographic features, disease progression, antiretroviral therapy (ART), resistance young people aged 10 years or more living United Kingdom Ireland reported to National Study HIV Pregnancy Childhood (NSHPC) prospective annual follow-up...
The aim of the study was to determine time to, and risk factors for, triple-class virological failure (TCVF) across age groups for children adolescents with perinatally acquired HIV infection older adults heterosexually infection.
Abstract Background It is widely accepted that the risk of hepatitis C virus (HCV) vertical transmission (VT) 5%–6% in monoinfected women, and 25%–40% HCV infection clears spontaneously within 5 years. However, there no consensus on how VT rates should be estimated, a lack information “net” clearance. Methods We reanalyzed data 1749 children 3 prospective cohorts to obtain coherent estimates overall rate net clearance at different ages. Clearance were used impute proportion uninfected who...
ABSTRACT Aim Recognizing the dearth of qualitative research on hepatitis C virus (HCV) infection associated with injecting drug use in UK, this paper summarizes insights from a study exploring social relations HCV risk management among injectors London. Method Adopting an inductive approach to data collection and analysis, 59 depth tape‐recorded interviews were undertaken 2001 recruited via user networks. Results While access equipment was reportedly good, needle syringe sharing continued...
ABSTRACT Aims To compare the prevalence of personality disorder in alcohol and drug populations with special attention to its impact on psychopathology service characteristics. Design Cross‐sectional survey. Setting Three four services urban UK centres. Participants Two hundred sixteen 64 patients randomly sampled from current treatment populations. Measurements A population census recorded demographic diagnostic data. Patient interviews assessed presence, cluster type severity using Quick...
We found a high prevalence of HIV among injecting drug users (IDU) 54% in Tallinn and 90% Kohtla Jarve, Estonia. Risk factors for included use the 'china white', being registered as an IDU at treatment clinic, sharing equipment with sex partners. Differences existed risk behaviour between cities. An urgent scale-up prevention is needed. It also important to explore how local 'risk environments' mediate transmission.
Background: Few studies have directly compared response to antiretroviral therapy (ART) between children living in well-resourced and resource-limited settings. In settings non-HIV contributors could reduce the beneficial effects of ART. We compare predictors short-term immunological, virological, growth ART HIV-infected United Kingdom/Ireland Kampala. Methods: analyzed prospective cohort data from 54 UK/Irish hospitals (the Collaborative HIV Paediatric Study) Mulago Hospital, Kampala,...