Mariam Sylla
A5047341084- HIV/AIDS Research and Interventions
- Child Nutrition and Water Access
- Pneumonia and Respiratory Infections
- Global Maternal and Child Health
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Respiratory viral infections research
- HIV-related health complications and treatments
- Emergency and Acute Care Studies
- Bacterial Infections and Vaccines
- Iron Metabolism and Disorders
- Tuberculosis Research and Epidemiology
- Infant Development and Preterm Care
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- Neonatal and fetal brain pathology
- Hemoglobinopathies and Related Disorders
- Neonatal Respiratory Health Research
- Healthcare Systems and Practices
- Mosquito-borne diseases and control
- Breastfeeding Practices and Influences
- Neonatal and Maternal Infections
- HIV/AIDS Impact and Responses
- Amoebic Infections and Treatments
- Poverty, Education, and Child Welfare
University of Bamako
2013-2025
Mali-Folkecenter
2008-2024
Centre Hospitalier Universitaire de Tours
2024
Université des Sciences, des Techniques et des Technologies de Bamako
2014-2023
World Health Organization - Pakistan
2022
World Health Organization
2022
Clinique Romande de Réadaptation
2014-2021
Laboratoire National de Référence
2020
Universität der Bundeswehr München
2019
Institut für Mikrobiologie der Bundeswehr
2019
Background Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric cohorts and cohort networks, allowing comparisons in "real-life" settings across multiple regions. We describe geographic temporal characteristics mortality outcomes APHs regions, including South America Caribbean, North America, Europe, sub-Saharan Africa, Southeast Asia. Methods findings Through Collaborative...
Some countries have undertaken programs that included scaling up kangaroo mother care. The aim of this study was to systematically evaluate the implementation status facility-based care services in four African countries: Malawi, Mali, Rwanda and Uganda. A cross-sectional, mixed-method research design used. Stakeholders provided background information at national meetings individual interviews. Facilities were assessed by means a standardized tool previously applied other settings, employing...
Background There are very limited data on children with pneumonia in Mali. The objective was to assess the etiology and factors associated community-acquired hospitalized <5 years of age Methods A prospective hospital-based case-control study implemented Pediatric department Gabriel Touré University Hospital at Bamako, Mali, between July 2011-December 2012. Cases were radiologically-confirmed pneumonia; Controls without respiratory features, matched for period. Respiratory specimens,...
To evaluate the virological response and to describe resistance profiles in case of failure after 6 months first-line highly active antiretroviral therapy (HAART) HIV-1-infected children living resource-limited settings. Ninety-seven who started two nucleoside reverse transcriptase inhibitors (NRTIs) one non-nucleoside inhibitor (NNRTI) (mainly zidovudine/lamivudine/nevirapine) Mali were prospectively studied. Virological (VF) was defined as loss follow-up, death or HIV-1 RNA viral load (VL)...
For epidemiological and surveillance purposes, it is relevant to monitor the distribution dynamics of Streptococcus pneumoniae serotypes. Conventional serotyping methods do not provide rapid or quantitative information on serotype loads. Quantitative may enable prediction invasiveness a specific compared other serotypes carried. Here, we describe novel, multiplex real-time PCR assay for identification quantification 40 most prevalent pneumococcal impacts in pneumonia specimens from emerging...
This study aimed to assess the seroprevalence of SARS-CoV-2 among children attending pediatric consultations in Bamako, Mali, using a rapid diagnostic test (RDT) on fingertip or venous blood samples. A single-center, cross-sectional was conducted from May September 2022 at Pediatric Hospital Mali. Children aged 1 15 years underwent phlebotomy sampling for antibody testing Abbott Panbio COVID-19 IgG/IgM Test. Demographic data and potential risk factors (for children: age, gender, place...
ObjectivesTo assess the prevalence of sexually transmitted infections (STIs), antimicrobial resistance and cervical lesions among women from Sikasso, Mali.MethodsWomen infected with human immunodeficiency virus (HIV) (n=44) HIV-negative (n=96) attending cancer screening were included. Screening for papillomavirus (HPV), Chlamydia trachomatis (CT), Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG) Trichomonas vaginalis (TV) was performed using polymerase chain reaction assays, herpes...
Introduction Existing risk assessment tools to identify children at of hospitalised pneumonia-related mortality have shown suboptimal discriminatory value during external validation. Our objective was derive and validate a novel tool aged 2–59 months across various settings. Methods We used primary, baseline, patient-level data from 11 studies, including evaluated for pneumonia in 20 low-income middle-income countries. Patients with complete were included logistic regression model assess the...
ObjectivesWe determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratification and chest-indrawing in-hospital factors.MethodsWe report characteristics pneumonia-related of children aged 2-59 months who were included Pneumonia Research Partnership to Assess WHO Recommendations dataset. We developed multivariable logistic regression models identify factors.ResultsAmong 285,839 children, 164,244 (57.5%) from hospital-based studies included. case fatality (CFR) without...
In Bamako, Mali, where surveillance revealed a high incidence of Haemophilus influenzae type b (Hib) invasive disease, Hib conjugate vaccine was introduced into the Expanded Program on Immunization and impact assessed. Annual confirmed hospitalizations for infants 0–11 months age fell from 175/10 5 to 44/10 ( P < 0.001); among 6–7 377/10 69/10 , (82% decrease, 0.001). Invasive Streptococcus pneumoniae remained unchanged. baseline serosurvey, only 3/200 (1.5%) had protective...
Abstract Background Retinoblastoma (Rb) is the most common intraocular primary malignancy in children. In industrialised countries, cure rate about 95%. We present results of a prospective study on management Rb paediatric oncology unit Gabriel Touré Teaching Hospital and African Institute Tropical Ophthalmology, from November 1, 2011 to December 31, 2015. Procedure The aims this were evaluate treatment localised Rb, ocular prosthesis after enucleation, conservative for bilateral as well...
Integrase inhibitors (INIs) are a potent option for HIV treatment. Limited data exist on INI resistance in West Africa, particularly children living with HIV/AIDS. We determined the prevalence of integrase gene polymorphisms and frequency naturally occurring amino acid (aa) substitutions at positions associated resistance. Dried blood spot (DBS) samples were obtained from one hundred seven (107) HIV-1-infected aged less than 15 years old two African countries, Benin Mali. All naïve to...
Limited data exist on drug resistance and antiretroviral treatment (ART) outcomes in HIV-1-infected children West Africa. We determined the prevalence of baseline correlates virologic failure (VF) a cohort ART-naive <10 years age initiating ART Mali.Reverse transcriptase protease genes were sequenced at (before ART) 6 months. Resistance was defined according to Stanford HIV Genotypic database. VF as viral load ≥1000 copies/mL after months ART. Logistic regression used evaluate factors...
Abstract Introduction Stunting is a key issue for adolescents with perinatally acquired HIV (APH) that needs to be better understood. As part of the IeDEA multiregional consortium, we described growth evolution during adolescence APH on antiretroviral therapy (ART). Methods We included data from sub‐Saharan Africa, Asia‐Pacific, and Caribbean, Central South America regions collected between 2003 2016. Adolescents ART, reporting infection or entering care before 10 years age, at least one...
Existing scores to identify children at risk of hospitalized pneumonia-related mortality lack broad external validation. Our objective was externally validate three such scores. We applied the Respiratory Index Severity in Children (RISC) for HIV-negative children, RISC-Malawi, and Pneumonia Etiology Research Child Health (PERCH) REsearch Partnerships Assess WHO REcommendations (PREPARE) data set. The PREPARE set includes pooled from 41 studies on pediatric pneumonia across world. calculated...
Abstract Introduction Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric Education Research (CIPHER) global project. Methods Data were collected between 1994 2015 11 CIPHER networks worldwide. perinatally acquired infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, at least one height or count...
In resource-limited settings, few data are available on virological failure after long-term first-line antiretroviral therapy. This study characterized the genotypic resistance patterns at time of least 36 months a regimen in Mali, West Africa.Plasma samples from 84 patients who were receiving treatment and with an HIV-1 RNA viral load (VL) >1000 copies/mL analysed. Genotypic testing was performed drug interpreted according to latest version National Agency for HIV Hepatitis Research...
We assessed a nutritional support intervention in malnourished HIV-infected children HIV-care program of the University Hospital Gabriel Touré, Bamako, Mali.All younger than 15 years were diagnosed for malnutrition between 07 and 12, 2014. Malnutrition was defined according to WHO growth standards with Z-scores. Two types studied: acute (AM) chronic (CM). All participants enrolled 6-month prospective interventional cohort, receiving Ready-To-Use Therapeutic Food, type malnutrition. The...
Background: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation HAART could lead to functional cure. Objectives: We described the factors associated with HIV antibody levels and viral reservoir size HAART-treated VHIV children. Methods: Study included 97 virological suppression, Bamako, Mali. The anti-gp41 activities serostatus were assessed. was measured by quantifying total cell-associated DNA. Results:...