A5086765478- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
- Global Maternal and Child Health
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Respiratory viral infections research
- HIV/AIDS Impact and Responses
- Immune responses and vaccinations
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Outbreaks Research
- Viral Infections and Immunology Research
- Malaria Research and Control
- Monoclonal and Polyclonal Antibodies Research
- Viral-associated cancers and disorders
- Child Nutrition and Water Access
- Sex work and related issues
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
Barcelona Institute for Global Health
2015-2024
Universitat de Barcelona
2015-2024
Manhiça Health Research Centre
2015-2024
Hospital Clínic de Barcelona
2008-2021
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2011-2020
Barcelona Centre for International Affairs
2011-2017
Universitat Autònoma de Barcelona
2015
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2008-2012
Instituto Nacional de Saúde
2008-2011
Eduardo Mondlane University
2009
A monoclonal antibody (MCI20.6) which inhibited measles virus (MV) binding to host cells was previously used characterize a 57- 67-kDa cell surface glycoprotein as potential MV receptor. In the present work, this (gp57/67) immunopurified, and N-terminal amino acid sequencing identified it human membrane cofactor protein (CD46), member of regulators complement activation gene cluster. Transfection nonpermissive murine with recombinant expression vector containing CD46 cDNA conferred three...
WHO and partners have learnt from the mis-steps in response to 2009 H1N1 influenza pandemic1 established Access COVID-19 Tools (ACT) Accelerator promote equitable access vaccines, therapeutics, diagnostics.2 However, many high-income countries already bilateral agreements with manufacturers of vaccines.3 The COVAX Facility ACT has 2 billion doses pre-qualified vaccines during 2021, but this represents only 20% vaccine needs participating countries.
ABSTRACT We investigated the relative importance of binding site occupancy and epitope specificity in antibody neutralization human immunodeficiency virus (HIV) type 1 (HIV-1). The a T-cell-line-adapted HIV-1 isolate (MN) was analyzed with number monovalent recombinant Fab fragments (Fabs) monoclonal antibodies range specificities covering all confirmed gp120-specific epitopes. Binding Fabs to monomeric gp120 determined by surface plasmon resonance, whole functional oligomeric indirect...
BackgroundCurrent recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information the safety efficacy of their combined use.Methods1030 Mozambican all gravidities received a long-lasting ITN during antenatal clinic (ANC) visits and, irrespective HIV status, were enrolled randomised, double blind, placebo-controlled trial, assess 2-dose sulphadoxine-pyrimethamine (SP). The main...
Background Maternal mortality is a major health problem concentrated in resource-poor regions. Accurate data on its causes using rigorous methods lacking, but essential to guide policy-makers and professionals reduce this intolerable burden. The aim of study was accurately describe the maternal death order contribute reduction, one regions world with highest ratios. Methods Findings We conducted prospective between October 2002 December 2004 tertiary-level referral hospital Maputo,...
In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand longitudinal effects HIV-1 human microbiota, we prospectively 49 Mozambican subjects diagnosed with recent (RHI) and 54 HIV-1-negative controls for 9–18 months compared them 98 chronically HIV-1-infected treated antiretrovirals (n = 27) or not 71). We show that RHI increased fecal adenovirus shedding, which persists during...
Background S outhern A frican countries have borne the brunt of HIV / AIDS pandemic. Monitoring epidemiological dynamics is critical to identify populations at greatest risk infection and guide control strategies. Methods cross‐sectional community‐based study determine age‐ sex‐specific prevalence among individuals aged 18–47 years was carried out in M anhiça, southern ozambique. Participants were randomly selected from demographic surveillance system place area voluntary counselling testing...
Objectives: To assess the incidence, predictors, and outcomes of Kaposi sarcoma-associated paradoxical immune reconstitution inflammatory syndrome (KS-IRIS) in antiretroviral therapy (ART)-naive HIV-infected patients with sarcoma initiating ART both well resourced limited-resourced settings. Design: Pooled analysis three prospective cohorts ART-naive from sub-Saharan Africa (SSA) one UK. Methods: KS-IRIS case definition was standardized across sites. Cox regression Kaplan–Meier survival were...
Here we provide a brief "primer" to assist healthcare providers in correcting growing body of misinformation surrounding COVID-19 vaccines. To date, just over 100 million immunizations have been administered, led by the United States accounting for more than one-third (35 million), followed China (24 million) and European Union (14 million). In 2020, up or people surveyed both globally indicated they might refuse first vaccines when released through emergency use authorization (EUA). Their...
ABSTRACT Measles is a highly contagious disease currently responsible for over one million childhood deaths, particularly in the developing world. Since alpha/beta interferons (IFNs) are pivotal players both nonspecific antiviral immunity and specific cellular responses, their induction or suppression by measles virus (MV) could influence outcome of viral infection. In this study we compare IFN sensitivity laboratory-passaged attenuated MV strains Edmonston Moraten with those recent...
ObjectivesThe objective of this study was to inform public health actions limit first-line ART failure and HIV drug resistance in Mozambique.
Health-related stigma is a complex phenomenon, the experience of which intersects with those other adversities arising from diversity social inequalities and oppressive identities like gender, sexuality, poverty - concept called "intersectionality". Understanding this intersectionality between health-related forms marginalization can provide fuller more comprehensive picture associated health conditions. The main objective paper to build upon in by exploring convergence experiences across...
The COVID-19 pandemic is a public health crisis of unprecedented proportions. Despite unparalleled rates vaccination and mass testing in certain parts the world, virus rages on. Since SARS-CoV-2, that causes COVID-19, was first isolated Wuhan, China, on 7 January 2020, more than 243 million cases 4·9 deaths have been reported worldwide at time writing.1JHUCOVID-19 Dashboard. 2021; (accessed 18/10/2021)https://coronavirus.jhu.edu/map.htmlGoogle Scholar Widespread timely diagnosis are critical...
A surface glycoprotein (gp57/67) was previously shown to be involved in measles virus (MV) binding and characterized our laboratory. Here, we described down-regulation of cell gp57/67 after infection with MV. This effect is specific for MV since cells infected canine distemper virus, closely related MV, did not down-regulate gp57/67. The decrease correlated expression glycoproteins more particularly the haemaggluttinin (MV-H). Indeed, MV-H a vaccinia recombinant coding necessary sufficient...
Background: The impact and relevance of immune reconstitution inflammatory syndrome-associated with Kaposi sarcoma (IRIS-KS) has not been assessed in sub-Saharan African countries, where the bulk HIV-1 KS-associated herpesvirus (KSHV) coinfection occurs. Understanding risk factors for developing IRIS-KS would aid identification improvement clinical management high-risk patients. Methods: Sixty-nine consecutive KSHV coinfected Mozambican adults initiating cART were prospectively followed...
Monitoring the HIV epidemic in a defined population is critical for planning treatment and preventive strategies. This especially important sub-Saharan Africa, which harbours highest burden of disease.To estimate incidence adults aged 18-47 years old to investigate spatial variations prevalence Manhiça, semi-rural area southern Mozambique.Two cross-sectional community-based surveys were conducted 2010 2012 determine prevalence. Individual participants randomly selected from demographic...
ABSTRACT One of the major mechanisms by which measles virus (MV) infection causes disease and death is suppression immune response. The nonresponsiveness MV-infected human lymphocytes to mitogens a partial block in G 0 /G 1 phase cell cycle observed vitro thought reflect vivo immunosuppression. In order molecularly dissect MV-induced immunosuppression, we analyzed expression surface activation markers cycle-regulatory proteins T lymphocytes. MV Edmonston (MV-Ed) could induce maintain high...