A5081252952- Cervical Cancer and HPV Research
- Autopsy Techniques and Outcomes
- Global Cancer Incidence and Screening
- Global Maternal and Child Health
- Viral-associated cancers and disorders
- Tuberculosis Research and Epidemiology
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Global Health and Surgery
- Hepatitis B Virus Studies
- Helicobacter pylori-related gastroenterology studies
- Climate Change and Health Impacts
- Healthcare cost, quality, practices
- Advances in Oncology and Radiotherapy
- Child Nutrition and Water Access
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Data-Driven Disease Surveillance
- Lymphoma Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Global Health and Epidemiology
- Mycobacterium research and diagnosis
- Pregnancy and preeclampsia studies
- Forensic Entomology and Diptera Studies
- Ocular Oncology and Treatments
Maputo Central Hospital
2016-2025
Eduardo Mondlane University
2016-2025
Health Net
2023
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2021
National Directorate of Geology
2019
Rush University Medical Center
2018
Columbia College - Missouri
2018
University of Chicago Medical Center
2018
Institució Catalana de Recerca i Estudis Avançats
2016
Ministry of Health
2010-2015
Breast cancer is the leading diagnosis and second most common cause of deaths in sub-Saharan Africa (SSA). Yet, there are few population-level survival data from none on differences by stage at diagnosis. Here, we estimate breast within SSA area, country-level human development index (HDI). We obtained a random sample 2,588 incident cases, diagnosed 2008-2015 14 population-based registries 12 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mali, Mauritius, Mozambique, Namibia, Seychelles,...
Background There is an urgent need to identify tools able provide reliable information on the cause of death in low-income regions, since current methods (verbal autopsy, clinical records, and complete autopsies) are either inaccurate, not feasible, or poorly accepted. We aimed compare performance a standardized minimally invasive autopsy (MIA) approach with that gold standard, diagnostic (CDA), series adults who died at Maputo Central Hospital Mozambique. Methods Findings In this...
Background Maternal mortality is a major health problem concentrated in resource-poor regions. Accurate data on its causes using rigorous methods lacking, but essential to guide policy-makers and professionals reduce this intolerable burden. The aim of study was accurately describe the maternal death order contribute reduction, one regions world with highest ratios. Methods Findings We conducted prospective between October 2002 December 2004 tertiary-level referral hospital Maputo,...
Background and Aims Complete diagnostic autopsies (CDA) remain the gold standard in determination of cause death (CoD). However, performing CDAs developing countries is challenging due to limited facilities human resources, poor acceptability. We aimed develop test a simplified minimally invasive autopsy (MIA) procedure involving organ-directed sampling with microbiology pathology analyses implementable by trained technicians low- income settings. Methods A standardized scheme for MIA has...
Over 5 million stillbirths and neonatal deaths occur annually. Limited imprecise information on the cause of these hampers progress in achieving global health targets. Complete diagnostic autopsies (CDAs)-the gold standard for death determination-are difficult to perform most high-burden settings. Therefore, validation simpler more feasible methods is needed.In this observational study, validity a minimally invasive autopsy (MIA) method determining was assessed 18 41 by comparing results MIA...
Background In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually low- and middle-income countries remains poor, partly because inadequacy reduced precision methods currently utilized these settings to investigate causes death (CoDs). The study objective was validate use a minimally invasive autopsy (MIA) approach as an adequate more acceptable substitute for complete diagnostic (CDA)...
Abstract Cervical cancer is the leading cause of death in African women. We sought to estimate population‐based survival and evaluate excess hazards for mortality women with cervical cancer, examining effects country‐level Human Development Index (HDI), age stage at diagnosis. selected a random sample 2760 incident cases, diagnosed 2005 2015 from 13 registries 11 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Uganda Zimbabwe)...
Already a major cause of death and disability in high-income countries, the burden stroke sub-Saharan Africa is also expected to be high. However, specific data are scarce from resource-poor countries. We studied incidence, characteristics, short-term consequences hospitalizations for Maputo, Mozambique.Over 12 months, comprehensive all local patients admitted any hospital Maputo with new event were prospectively captured according World Health Organization's STEPwise approach surveillance...
The minimally invasive autopsy (MIA) is being investigated as an alternative to complete diagnostic autopsies for cause of death (CoD) investigation. Before potential implementation the MIA in settings where post-mortem procedures are unusual, a thorough assessment its feasibility and acceptability essential.We conducted socio-behavioural study at community level understand local attitudes perceptions related hypothetical conducting MIAs six distinct Gabon, Kenya, Mali, Mozambique, Pakistan....
Abstract Cryptococcosis is a major opportunistic infection and one of the leading causes death in adults living with HIV sub-Saharan Africa. Recent estimates indicate that more than 130,000 people may die annually cryptococcal meningitis this region. Although complete diagnostic autopsy (CDA) considered gold standard for determining cause death, it seldom performed low income settings. In study, CDA was 284 deceased patients from Mozambique (n = 223) Brazil 61). depth histopathological...
Background: The impact and relevance of immune reconstitution inflammatory syndrome-associated with Kaposi sarcoma (IRIS-KS) has not been assessed in sub-Saharan African countries, where the bulk HIV-1 KS-associated herpesvirus (KSHV) coinfection occurs. Understanding risk factors for developing IRIS-KS would aid identification improvement clinical management high-risk patients. Methods: Sixty-nine consecutive KSHV coinfected Mozambican adults initiating cART were prospectively followed...
Background Despite global health efforts to reduce maternal mortality, rates continue be unacceptably high in large parts of the world. Feasible, acceptable, and accurate postmortem sampling methods could provide necessary evidence improve understanding real causes guiding design interventions this burden. Methods findings The validity a minimally invasive autopsy (MIA) method determining cause death was assessed an observational study 57 deaths by comparing results MIA with those gold...
Abstract Background Minimally invasive tissue sampling (MITS) is a simplified postmortem examination technique that has shown to be an adequate approach for cause of death investigation in low-resource settings. It requires relatively low level infrastructures and can performed by health professionals with no background pathology. A training program been developed the Child Health Mortality Prevention Surveillance (CHAMPS) network guarantee standardization specimen collection techniques,...
Cervical cancer is the most prevalent in Mozambique, with endocervical adenocarcinoma accounting for approximately 5.5% of cases. Knowledge regarding HPV genotypes limited, within this setting. This study aimed to investigate human papillomavirus (HPV) prevalence and a cohort patients context Mozambique's recently introduced vaccination programme, considering country's HIV-endemic Forty consecutive cases diagnosed at Maputo Central Hospital between 2017 2018, limited clinical data available,...
Abstract Background There is paucity of information on the role cytomegalovirus (CMV) infection as a cause stillbirths or childhood deaths in low-and middle-income countries (LMICs). We investigated attribution CMV-disease causal pathway to and children <5 years age seven LMICs participating Child Health Mortality Prevention Surveillance (CHAMPS) network. Methods analyzed decedents enrolled between December 2016 July 2023. Deaths were using post-mortem minimally invasive tissue...
Background Maternal mortality is a major public-health problem in developing countries. Extreme differences maternal rates between developed and countries indicate that most of these deaths are preventable. Most information on the causes death areas based clinical records verbal autopsies. Clinical diagnostic errors may play significant role this might also have implications for evaluation current estimations death. Methods Findings A retrospective analysis clinico-pathologic correlation was...
Sensitive tools are needed to accurately establish the diagnosis of tuberculosis (TB) at death, especially in low-income countries. The objective this study was evaluate burden TB a series patients who died tertiary referral hospital sub-Saharan Africa using an in-house real time PCR (TB-PCR) and Xpert MTB/RIF Ultra (Xpert Ultra) assay.Complete diagnostic autopsies were performed 223 deaths (56.5% being HIV-positive), including 54 children, 57 maternal 112 other adults occurring Maputo...
Postmortem studies are crucial for providing insight into emergent diseases. However, a complete autopsy is frequently not feasible in highly transmissible diseases due to biohazard challenges. Minimally invasive (MIA) needle-based approach aimed at collecting samples of key organs without opening the body, which may be valid alternative these cases. We to: (a) provide biosafety guidelines conducting MIAs COVID-19 cases, (b) compare performance MIA versus autopsy, and (c) evaluate safety...