Nontuthuzelo Somdyala
A5078465514- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Colorectal Cancer Screening and Detection
- Ovarian cancer diagnosis and treatment
- Mycotoxins in Agriculture and Food
- Wheat and Barley Genetics and Pathology
- Glioma Diagnosis and Treatment
- Plant Pathogens and Fungal Diseases
- Advances in Oncology and Radiotherapy
- Prostate Cancer Diagnosis and Treatment
- Global Public Health Policies and Epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Global Maternal and Child Health
- HIV/AIDS Impact and Responses
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Childhood Cancer Survivors' Quality of Life
- Economic and Financial Impacts of Cancer
- Hepatitis B Virus Studies
- Acute Lymphoblastic Leukemia research
- Health and Conflict Studies
- Healthcare Systems and Reforms
- Nutritional Studies and Diet
- Intraperitoneal and Appendiceal Malignancies
- Ferroptosis and cancer prognosis
South African Medical Research Council
2008-2024
Liechtenstein Institute
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
African Organisation for Research and Training in Cancer
2020
In-Q-Tel
2010
BackgroundThe poor health of South Africans is known to be associated with a quadruple disease burden. In the second National Burden Disease (NBD) study, we aimed analyse cause death data for 1997–2012 and develop national, population group, provincial estimates levels causes mortality.MethodWe used underlying from notifications obtained Statistics Africa. These were adjusted completeness using indirect demographic techniques adults comparison survey census child mortality. A regression...
Cervical cancer is the second most common and leading cause of death in women sub-Saharan Africa (SSA).
Breast cancer (BC) is the leading cause of in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported Uganda and Zimbabwe. However, magnitude these rising trends premenopausal postmenopausal women unknown most African countries. We used data from Cancer Registry Network on incident breast cancers 11 population-based registries 10 countries representing each four SSA regions. explored changes among before after age 50 by calendar period and, where possible, generational...
Abstract Cervical cancer is the leading cause of death in African women. We sought to estimate population‐based survival and evaluate excess hazards for mortality women with cervical cancer, examining effects country‐level Human Development Index (HDI), age stage at diagnosis. selected a random sample 2760 incident cases, diagnosed 2005 2015 from 13 registries 11 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Uganda Zimbabwe)...
BackgroundLeukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults 15–99 diagnosed with malignancy during 2000–14 in 61 countries. Here, aimed to examine worldwide trends survival from leukaemia, by age morphology, young patients 0–24 years).MethodsWe 258 population-based cancer registries countries participating CONCORD-3 that submitted on leukaemia. We grouped as (0–14 years), adolescents (15–19 (20–24...
The fumonisins are mycotoxins produced mainly by Fusarium verticillioides and F. proliferatum in maize, the predominant cereal staple for subsistence farming communities southern Africa. In order to assess exposure these Bizana (now known as Mbizana) Centane magisterial areas of former Transkei region Eastern Cape Province South Africa, actual maize consumption different age groups was measured. 1-9 years (n = 215) 10-17 240) years, mean (+/-standard error) 246 +/- 10.8 368 10.3 g per person...
National trends in age-standardised death rates (ASDRs) for non-communicable diseases (NCDs) South Africa (SA) were identified between 1997 and 2010.As part of the second Burden Disease Study, vital registration data used after validity checks, proportional redistribution missing age, sex population group, demographic adjustments incompleteness, identification misclassified AIDS deaths. Garbage codes redistributed proportionally to specified by group. ASDRs calculated using mid-year...
Abstract Background: Prostate cancer is the leading in men sub-Saharan Africa (SSA) regarding incidence and mortality. Published data from a few registries SSA suggest that rates are still rising, but there little comprehensive information on time trends of prostate incidence. Methods: We analyzed registry 13,170 incident cases aged 40 years or above, 12 population-based 11 countries, with at least 10-year span comparable data. Results: observed an increase cumulative risks (CR)...
Survival is a key metric of the effectiveness health system in managing cancer. We set out to provide comprehensive examination worldwide variation and trends survival from brain tumors adults, by histology.We analyzed individual data for adults (15-99 years) diagnosed with tumor (ICD-O-3 topography code C71) during 2000-2014, regardless behavior. Data underwent 3-phase quality control as part CONCORD-3. estimated net 11 histology groups, using unbiased nonparametric Pohar Perme...
The Cancer Survival in Africa, Asia, and South America project (SURVCAN-3) of the International Agency for Research on aims to fill gaps availability population-level cancer survival estimates from countries these regions. Here, we analysed 18 cancers using data member registries African Registry Network across 11 sub-Saharan Africa.
Abstract Cancer incidence rates and patterns are reported for a rural population, living in the Eastern Cape Province of South Africa period 1998–2002. The population‐based cancer registry has operated 20 years, using both active passive methods case finding, through collaborations with 19 health facilities: 11 district hospitals, 7 referral hospitals 1 regional laboratory. age standardized all cancers were 73.1 per 100,000 males 64.1 females. leading top 5 oesophagus (32.7 100,000), lung...
There are limited population-based survival data for colorectal cancer (CRC) in sub-Saharan Africa. Here, 1707 persons diagnosed with CRC from 2005 to 2015 were randomly selected 13 registries operating 11 countries Vital status was ascertained medical charts or through next of kin. 1-, 3- and 5-year overall relative rates all each registry calculated using the Kaplan-Meier estimator. Multivariable analysis used examine associations age at diagnosis, stage country-level Human Development...
Abstract Background Global variations in survival for brain tumors are very wide when all histological types considered together. Appraisal of international differences should be informed by the distribution histology, but little is known beyond Europe and North America. Methods The source analysis was CONCORD database, a program global surveillance cancer trends, which includes tumor records individual patients from more than 300 population-based registries. We aged 0-99 years who were...
Abstract Objectives To estimate observed and relative survival of prostate cancer patients in sub-Saharan Africa (SSA) to examine the influence age, stage at diagnosis Human Development Index (HDI). Patients methods In this comparative registry study, we selected a random sample 1752 incident cases malign prostatic neoplasm from 12 population-based registries 10 SSA countries, registered between 2005 2015. We analyzed data using Kaplan-Meier Ederer II obtain outcome estimates flexible...
The production and consumption of home-brewed Xhosa maize beer is a widespread traditional practice in the former Transkei region South Africa. HPLC determination fumonisins B1 (FB1), B2 (FB2), B3 (FB3) samples collected two magisterial areas, Centane Bizana, showed wide range levels. All were positive for FB1, with mean level 281 ± 262 ng/mL from 38 to 1066 ng/mL. Total (FB1 + FB2 FB3) ranged 43 1329 ng/mL, 369 345 Data on are not available. On basis published data commercial Africa,...
As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and types distribution among unvaccinated population. Information prevalence adolescents young women Africa's Eastern Cape Province minimal. Therefore, this study investigates types, factors associated with infection amongst female learners. A sample composed 213 sexually active learners attending high schools Africa; median age 18 years, who provided...
Abstract In sub‐Saharan Africa, colorectal cancer (CRC) has historically been considered a rare disease, although some previous studies have suggested that the incidence is increasing. We examine time trends in of CRC using data from 12 population‐based registries 11 countries Africa were able to provide series for periods or more years, with earlier which recent rates may be compared. Age‐standardized highest higher‐income countries, and increasing all populations studied, these increases...
Background Measuring factors influencing time to presentation is important in developing and evaluating interventions promote timely cancer diagnosis, yet there a lack of validated, culturally relevant measurement tools. This study aimed develop validate the African Women Awareness CANcer (AWACAN) tool measure awareness breast cervical Sub-Saharan Africa (SSA). Methods Development AWACAN followed 4 steps: 1) Item generation based on existing measures literature. 2) Refinement items via...
Abstract Introduction Tumors of the central nervous system are among leading causes cancer-related death in children. Population-based cancer survival reflects overall effectiveness a health care managing cancer. Inequity access to world-wide may result disparities. Methods We considered children (0–14 years) diagnosed with brain tumor during 2000–2014, regardless behavior. Data underwent rigorous, three-phase quality control as part CONCORD-3. implemented revised version International...
Although the countries of Sub‐Sharan Africa represent among most rapidly growing and aging populations worldwide, no previous studies have examined cancer patterns in older adults region as a means to inform policies. Using data from Cancer Incidence Five Continents, we describe recent trends incidence rates for major sites aged ≥60 years people 0–59 comparison four selected population‐based registries Kenya (Nairobi), Republic South (Eastern Cape Province), Uganda (Kyadondo country),...