Login

Shyam S. Manraj

ORCID: 0009-0003-3898-6813
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
A5033668815
Research Areas
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Ferroptosis and cancer prognosis
  • Cancer Genomics and Diagnostics
  • Global Cancer Incidence and Screening
  • Circular RNAs in diseases
  • Cancer Cells and Metastasis
  • Colorectal Cancer Screening and Detection
  • Liver Disease Diagnosis and Treatment
  • Genetic factors in colorectal cancer

Ministry of Health and Quality of Life
 2023

 Colorectal cancer survival in sub‐Saharan Africa by age, stage at diagnosis and Human Development Index: A population‐based registry study
OPENALEX - Publications 
Cricket Gullickson Michael Goodman Yvonne Walburga Joko-Fru Freddy Houéhanou Rodrigue Gnangnon Guy N’Da and 15 more Mathewos Assefa Woldegeorgis Nathan Buziba Caroline Karugu Shyam S. Manraj Cesaltina Lorenzoni Rolf Iversen Hansen Anne Finesse Nontuthuzelo Somdyala Phiona Bukirwa Tatenda Chingonzoh Eric Chokunonga Biying Liu Eva Johanna Kantelhardt Donald Maxwell Parkin Ahmedin Jemal

There are limited population-based survival data for colorectal cancer (CRC) in sub-Saharan Africa. Here, 1707 persons diagnosed with CRC from 2005 to 2015 were randomly selected 13 registries operating 11 countries Vital status was ascertained medical charts or through next of kin. 1-, 3- and 5-year overall relative rates all each registry calculated using the Kaplan-Meier estimator. Multivariable analysis used examine associations age at diagnosis, stage country-level Human Development...

10.1002/ijc.33715 article EN International Journal of Cancer 2021-06-24
 Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

Abstract The low overall survival rates of patients with breast cancer in sub-Saharan Africa (SSA) are driven by regionally differing tumor biology, advanced stages at diagnosis, and limited access to therapy. However, it is not known whether regional differences the composition microenvironment (TME) exist affect patients’ prognosis. In this international, multicentre cohort study, 1,237 formalin-fixed, paraffin-embedded samples, including samples “African Breast Cancer-Disparities Outcomes...

10.1158/2326-6066.cir-22-0795 article EN Cancer Immunology Research 2023-04-14
 Supplementary Figure 1 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S1: Consort diagram of the analyzed samples</p>

10.1158/2326-6066.27026444.v1 preprint EN 2024-09-16
 Supplementary Figure 1 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S1: Consort diagram of the analyzed samples</p>

10.1158/2326-6066.27026444 preprint EN 2024-09-16
 Supplementary Figure 2 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S2: TILs in SSA</p>

10.1158/2326-6066.27026441 preprint NL 2024-09-16
 Supplementary Figure 3 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S3: Immune cell subpopulations in SSA</p>

10.1158/2326-6066.27026438 preprint FR 2024-09-16
 Supplementary Figure 2 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S2: TILs in SSA</p>

10.1158/2326-6066.27026441.v1 preprint NL 2024-09-16
 Supplementary Figure 4 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S4:PD-L1 expression and cytotoxicity</p>

10.1158/2326-6066.27026435 preprint EN 2024-09-16
 Supplementary Figure 3 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S3: Immune cell subpopulations in SSA</p>

10.1158/2326-6066.27026438.v1 preprint FR 2024-09-16
 Supplementary Figure 5 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S5: MHC I expression in SSA</p>

10.1158/2326-6066.27026432 preprint EN 2024-09-16
 Supplementary Figure 4 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S4:PD-L1 expression and cytotoxicity</p>

10.1158/2326-6066.27026435.v1 preprint EN 2024-09-16
 Supplementary Figure 5 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S5: MHC I expression in SSA</p>

10.1158/2326-6066.27026432.v1 preprint EN 2024-09-16
 Supplementary Figure 6 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S6: Multivariate Cox regression analysis of patient's survival.</p>

10.1158/2326-6066.27026429.v1 preprint EN 2024-09-16
 Supplementary Figure 6 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S6: Multivariate Cox regression analysis of patient's survival.</p>

10.1158/2326-6066.27026429 preprint EN 2024-09-16
 Supplementary Figure 6 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S6: Multivariate Cox regression analysis of patient's survival.</p>

10.1158/2326-6066.23283420 preprint EN cc-by 2023-06-02
 Supplementary Figure 3 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S3: Immune cell subpopulations in SSA</p>

10.1158/2326-6066.23283429 preprint FR cc-by 2023-06-02
 Supplementary Figure 4 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S4:PD-L1 expression and cytotoxicity</p>

10.1158/2326-6066.23283426 preprint EN cc-by 2023-06-02
 Supplementary Figure 1 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S1: Consort diagram of the analyzed samples</p>

10.1158/2326-6066.23283435 preprint EN cc-by 2023-06-02
Coming Soon ...